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Downloads
Views
Date
Relevance
Potential Scenario
156
views
88
downloads
0
comments
2015-Heiko_Enderling-Integrating experimental data to calibrate quantitative cancer models
For quantitative cancer models to be meaningful and interpretable the number of unknown parameters must be kept minimal. We focus on a tumor hierarchy of cancer stem and progenitor non-stem cancer cells.
cancer
tumor
fitting
agent-based
Potential Scenario
186
views
45
downloads
0
comments
1969-Israelsson-Johnsson-Phase-shift in Geotropic Oscillations a Theoretical and Experimental Study
The paper studies geotropical induced phase-shifts in circumnutations (turning) of Helianthus annus hypocotlys.
plant
oscillation
delay
circumnutation
turning
Potential Scenario
162
views
71
downloads
0
comments
1935 GFGause Article Predator Prey Oscillations
N/A
Lotka-Volterra
predator
paramecium
prey
cycle
oscillate
Potential Scenario
182
views
49
downloads
0
comments
2012-Transtrum-Qiu-Optimal experiment selection for parameter estimation in biological differential equation models
We explore the question to what extent parameters can be efficiently estimated by appropriate experimental selection.
experimental design
systems biology
Association & Data Fitting
reaction rates
decay rates
Potential Scenario
212
views
66
downloads
0
comments
2007-Helfgott-Seier-Some Mathematical and Statistical Aspects of Enzyme Kinetics
We will analyze some basic ideas behind enzyme kinetics, which allow us to deal with separable and linear differential equations as well as realize the need to use power series.
kinetics
Enzyme
experimental data
regresion
Potential Scenario
202
views
73
downloads
0
comments
2017-D_Goulet-Modeling, Simulating, and Parameter Fitting of Biochemical Kinetic Experiments
In many chemical and biological applications, systems of differential equations containing unknown parameters are used to explain empirical observations and experimental data. The differential equations are typically nonlinear.
optimization
Biochemistry
sensitivity analysis
chromatography
mass action
cluster analysis
conservation laws
dimerization
estrogen receptor protein
Potential Scenario
148
views
57
downloads
0
comments
2017-Bonin-EtAl-Mathematical modeling based on ordinary differential equations - promising approach to vaccinology
As a proof of concept, we developed a model of the immune response to vaccination against the yellow fever. Our simulations have shown consistent results when compared with experimental data available in the literature.
immune system
yellow fever
computational immunology
computational vaccinology
Potential Scenario
164
views
84
downloads
0
comments
2016-Bonin-EtAl-Mathematical modeling based on ordinary differential equations-vaccinology
We developed a model of the immune response to vaccination against the yellow fever. Our simulations have shown consistent results when compared with experimental data available in the literature.
Immunology
immune system
Antigen
vaccinology
yellow fever
Potential Scenario
130
views
49
downloads
0
comments
2010-Shianga-EtAl-Computational model of the human glucose-insulin regulatory system
A computational model of insulin secretion and glucose metabolism for assisting the diagnosis of diabetes mellitus in clinical research is introduced. The
glucose tolerance test
sum of squared residuals
multiple shooting method
cost function
Potential Scenario
144
views
63
downloads
0
comments
2008-Ribbing-EtAl-Mathematical models of diabetes progression
Writing a good model for diabetes progression is difficult because the long time span of the disease makes experimental verification of modeling hypotheses extremely awkward. underlying the
physiology
clinical trials
diabetes
diabetes progression
Potential Scenario
173
views
41
downloads
0
comments
1967-Israelsson- Johnsson-Circumnutations In Helianthus Annuus
A theory is given for circumnutations in plants, especially hypocotyls of Helianthus annuus, which were used as experimental material.
plant
oscillation
delay
circumnutation
turning
Modeling Scenario
1182
views
5494
downloads
0
comments
5-001-LSD-ModelingScenario
We describe the use of a two compartment model of a linear system of first order linear differential equations to model lysergic acid diethylamide (LSD) in the body. We provide the data from the literature.
LSD
Spanish
compartment
pharmacokinetics
lysergic acid diethylamide
Potential Scenario
235
views
68
downloads
0
comments
2006-Graves-Peckham-Pastor-2D differential equations model for mutualism
We develop from basic principles a two-species differential equations model which exhibits mutualistic population interactions.
population dynamics
Lotka-Volterra
growth rate
mutualism
Lichen
Potential Scenario
124
views
52
downloads
0
comments
2004-Aldo_Rescigno-On the use of pharmacokinetic models
In this paper I will define in a simple and logical way a set of useful pharmacokinetic parameters and show how their estimation depends on the assumed model.
compartment
steady state
pharmacokinetics
volume distribution
Potential Scenario
204
views
59
downloads
0
comments
2003-Yildirim-Mackey-Feedback Regulation in the Lactose Operon
A mathematical model for the regulation of induction in the lac operon in Escherichia coli is presented.
mRNA
lactose
lactose operon
feedback regulation
Modeling Scenario
224
views
259
downloads
0
comments
6-029-TumorGrowth-ModelingScenario
This modeling scenario guides a student familiar with single ordinary differential equation (ODE) models towards the development of a more complex system of two ODEs for describing the evolution of tumor growth over time.
Pop_Growth Pilot
logistic
comparment
tumor
synthetic data
sum of squares error
Modeling Scenario
431
views
119
downloads
0
comments
6-067-LotkaVolterra-ModelingScenario
This modeling scenario guides students through the process of fitting the Lotka-Volterra model of two differential equations to a real time series observational data. Students use the capabilities of R and R studio.
time series
data
competition
Lotka-Volterra
model fitting
prediction
gauseR
experimental
Potential Scenario
141
views
55
downloads
0
comments
2016-Lewnard-Townsend-Climatic and evolutionary drivers of phase shifts in the plague epidemics of colonial India
Our analysis shows that historical datasets can yield powerful insights into the transmission dynamics of reemerging disease agents with which we have limited contemporary experience to guide quantitative modeling and inference.
infectious disease
p
Vector-Borne Disease
lague
plague
Potential Scenario
135
views
62
downloads
0
comments
2016-Barbarossa-Kuttler-Mathematical Modeling of Bacteria Communication in Continuous Cultures
This paper presents a simple system of delay differential equations (DDEs) for quorum sensing of Pseudomonas putida with one positive feedback plus one (delayed) negative feedback mechanism.
gene regulatory networks
chemostat
bifurcation
Numerical Simulation
quorum sensing
Potential Scenario
227
views
52
downloads
0
comments
1999-Khorasheh-Ahmadi-Gerayeli-Application of Direct Search Optimization for Pharmacokinetic Parameter Estimation
For simple pharmacokinetic compartmental models, analytical solution to the governing differential equations provide a mean to evaluate the associated rate constants. Such methods, however, can not be used used for more complex multi-compartment...
sum of square errors
least squares
pharmacokinetics
lineteics
compartmental models
direct search
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