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1999-Khorasheh-Ahmadi-Gerayeli-Application of Direct Search Optimization for Pharmacokinetic Parameter Estimation
For simple pharmacokinetic compartmental models, analytical solution to the governing differential equations provide a mean to evaluate the associated rate constants. Such methods, however, can not be used used for more complex multi-compartment...
sum of square errors
least squares
pharmacokinetics
lineteics
compartmental models
direct search
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