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    2012-Brian_Ingalls-Mathematical Modelling in Systems Biology An Introduction
    This is a comprehensive text with much biology background to motivate the mathematical modeling, exercises and answers, and many rich examples.
    spatialsensitivity analysisgene regulatory networksstochasticbifurcationmetabolic networkselectrophysiologytransductionrate lawsbiochemical reactions
    Potential Scenario
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    2007-I-Liang_Chern-Mathematical Modeling and Differential Equations
    In this course, I will mainly focus on, but not limited to, two important classes of mathematical models by ordinary differential equations: • population dynamics in biology • dynamics in classical mechanics.
    population dynamicsecologydynamicsclassical mechanicschemical reaction
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    2017-D_Goulet-Modeling, Simulating, and Parameter Fitting of Biochemical Kinetic Experiments
    In many chemical and biological applications, systems of differential equations containing unknown parameters are used to explain empirical observations and experimental data. The differential equations are typically nonlinear.
    optimizationBiochemistrysensitivity analysischromatographymass actioncluster analysisconservation lawsdimerizationestrogen receptor protein
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    2012-Shargel-Yu-AccessPharmacy-Applied Biopharmaceutics and Pharmacokinetics
    Step by step formation of drug absorption models is shown with many good graphics of system and plots. Solutions are offered but no solution methods are shown.
    Michaelis-MentenEnzymesubstratecompartmentpharmacokineticsrate constanturinary dataabsorption rate
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    2009-Das-EtAl-Bioeconomic harvesting of a pre-predator fishery
    This paper deals with the problem of non-selective harvesting of a prey–predator system by using a reasonable catch-rate function instead of usual catch-per-unit-effort hypothesis.
    predator-preyharvestingPontryagin’s maximum principlebioeconomicbionomic equilibriumbiotechnical productivitycatch-rate functionoptimal equilibrium
    Potential Scenario
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    1957-Axelrod_ Brady_Witkop_Evarts-The Distribution and Metabolism of Lysergic Acid Diethylamide
    The development of a specific and sensitive method for the estimation of LSD in biological materials has enabled us to study the tissue distribution, excretion, rate of biotransformation, and metabolism of the drug, as well as the subcellular...
    mathematical modeldataLSDMetabolismbloodstreamlysergic acid diethylamidedistribution
    Modeling Scenario
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    1-085-DrugBolus-ModelingScenario
    Given data on the concentration of a drug in the plasma of a human in mg/L at certain time intervals in hours can we determine the rate at which the drug leaves the plasma as well as the initial amount administered in a intravenous bolus of the drug?
    concentrationsum of square errorsbolusdrugrate constantadminister
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    2010-Del-Ciello-EtAl-Modeling Disease
    We model the transmission of a disease through a population. Such modeling is very important to the study of epidemiology and the practice of medicine.
    diseasespreadcarriessymptomaticasymptomatic
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    10-100-InsectOutbreaks-ModelingScenario
    We use a system of difference equations that incorporates a temperature-dependent MPB population growth rate to model the outbreak and recovery cycle in mountain pine beetle-infested forests.
    ecologyclimate changeinsectinsect outbreaksinsect outbreaksolitary wave
    Modeling Scenario
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    1-160-HeartDeathRate-ModelingScenario
    Students simulate experience from a given data set which represents the heart death rate during the period 2000 - 2010 using several approaches to include exponential decay, difference equation, differential equation, and parameter estimation...
    dataheart death rate
    Modeling Scenario
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    6-025-WhalesAndKrill-ModelingScenario
    Students will use Excel to observe qualitative behavior in a simulation of a predator-prey model, with blue whales and krill as the predator and prey populations, respectively.
    krillwhalepredatpr-prey
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    2017-Adolfo_Rumbos-Differential Equations and modeling
    The study of any phenomenon in the physical or biological sciences, in which continuity and differentiability assumptions about the quantities in question can be made, invariably leads to a differential equation, or a system of differential...
    pendulumLotka Volterra equationsexistenceuniqueness
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    2013-Murray_Bourne-Modeling fish stocks
    It is possible to have a sustainable fishing industry with proper planning and strictly enforced quotas.
    logisticFishingfishing industryfish managementfood availabilityreeding ratewater temperature
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    2008-Yang-EtAl-Differential Equation Model of HIV Infection of CD T-Cells with Delay 
    Abstract: An epidemic model of HIV infection of CD4+ T-cells with cure rate and delay is studied. We include a baseline ODE version of the model, and a differential-delay model with a discrete time delay.
    virusT cellsHopf bifurcationendemic equilibrium
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    1-130-AspirinAbsorption-ModelingScenario
    We model the amount of aspirin absorbed by the human body at a constant rate. This is a ``zero-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
    pharmacokineticsdrugaspirin
    Modeling Scenario
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    6-010-SocialCampaign-ModelingScenario
    The epidemic modeling problem is formulated as a system of three nonlinear, first order differential equations in which three compartments (S, I, and R) of the population are linked.
    diseasegrowth rateJudgment and Decision MakingSIR modelinfections diseasesocial campaignrecovery ratedelay timejoining processquitting processexponential distribution
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    2005-Minna_Wedenberg-Pharmacokinetic modeling of gastric emptying
    The development of new drug substances is a complex, time consuming and expensive process. Reducing the time for drug development and avoiding late termination of candidate drugs are important challenges for the pharmaceutical industry.
    paracetamolpharmacokineticsstomachsmall intestinesulfapyridine
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    6-022-CannibalismPredatorPrey-ModelingScenario
    The Lotka-Volterra model tells us that the prey and predator exhibit a shifted cyclic behavior over time. In this module, we look at modifying this prey-predator model to consider the case when there is cannibalism in the predator species.
    stabilitypredator-preyequilibriaoscillationscannibalismphase planesspiral sinks
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    2015-Sivakumar-EtAl-Approximate Analytical Expression of Concentrations in a Kinetic Model for Biogas Generation from Banana Waste
    The initial value problem in a kinetic model for biogas generation from banana waste is discussed. The model involves the system of non-linear differential equations which has variety of non-linear rate function.
    chemical kineticsMichaelis-Menten kineticsanaerobic digestionacidogenic stepsbananamethanogenic stepswastes
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    2008-Jai-Li-Differential equations models for interacting wild and transgenic mosquito populations
    We formulate and study continuous-time models, based on systems of ordinary differential equations, for interacting wild and transgenic mosquito populations.
    Mosquito borne diseasespopulationsHolling-II-type mating ratestransgenic mosquitoesnonhyperbolic equilibriummosquitoes