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    Potential Scenario
    173

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    65

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    1964-Aghajanian-Bing-Persistence Of LSD In Plasma In Human Subjects
    Two micrograms per kilogram of LSD-25 was administered intravenously to five normal human subjects. The concentration of[ drug in plasma was determined serially over the subsequent 8 hours. We model this.
    LSDscoreplasmalysergic acid diethylamidehuman subjuects
    Potential Scenario
    160

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    48

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    1969-Carl_Metzler-A mathematical model for the pharmacokinetics of LSD effect
    Contains data on performance scores vs. plasma levels of LSD in human tissues.
    LSDtestingpharmacokineticsperformanceplasma level
    Modeling Scenario
    208

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    239

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    5-020-ParacetamolAbsorption-ModelingScenario
    We offer drug absorption data on paracetamol, an analgesic pain reliever, for two different sets of patients, vegetarian and non-vegetarian. Students build a two compartment model for plasma and non-plasma (tissue) compartments of human patients.
    paracetamolanalgesicvegetariannon-vegetarian
    Modeling Scenario
    476

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    194

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    5-012-LipoproteinModeling-ModelingScenario
    Data from a study on the amounts of low-density-lipoprotein (LDL), form of cholesterol, in blood plasma is presented. Students build, validate, and use a compartment model of the kinetic exchange of the LDL between body tissue and blood plasma.
    wildlifelow-density-lipoproteintracercompartment modelcholesterolblood plasmabody tissue
    Potential Scenario
    182

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    50

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    2012-Jambhekar-Breen-Extravascular Routes Of Drug Administration in Basic Pharamacokinetics
    This provides an excellent step-by-step of the physiology, construction of model, and notions like peak concentration as well as issues like lag time.
    concentrationphysiologydrugslag timeExtravascularPharamacokineticspeak time
    Potential Scenario
    280

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    70

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    1968-Wagner-Aghajanian-Bing-Correlation of performance test scores with tissue concentration of lysergic acid diethylamide
    This paper offers a two compartment model of lysergic acid diethylamide (LSD) in volunteer students and through parameter estimation models the amount of LSD in the tissue after its initial administration through the plasma.
    LSDcorrelation coefficientcompartment modellysergic acid diethylamideperformancetest scoretissue concentration
    Modeling Scenario
    297

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    178

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    5-010-DNADegradation-ModelingScenario
    We ask students to use the system of first order linear differential equations given in a source paper and estimates of the data from laboratory procedures from a plot to estimate the parameters and complete the modeling process.
    DNA\kinetisplasmaratpharmacokinetis
    Potential Scenario
    164

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    43

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    1971-Boyes-Scott-Jebson-Godman-Julian-Lidocaine in Man
    Plasma levels of lidocaine were measured in 5 normal male volunteers following both intravenous and oral administration of the drug.
    pPharmacologypharmacokineticslidocaine
    Modeling Scenario
    309

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    228

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    1-085-DrugBolus-ModelingScenario
    Given data on the concentration of a drug in the plasma of a human in mg/L at certain time intervals in hours can we determine the rate at which the drug leaves the plasma as well as the initial amount administered in a intravenous bolus of the drug?
    concentrationsum of square errorsbolusdrugrate constantadminister
    Potential Scenario
    133

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    56

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    2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
    This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
    absorptioncompartmentbloodstreamplasmapharmacokineticsdrugpharmacodynamics
    Potential Scenario
    140

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    80

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    2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
    This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
    absorptioncompartmentbloodstreamplasmapharmacokineticspharmacodynamicstherapeutic concentration rangedrug dispositiondrug response
    Modeling Scenario
    650

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    394

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    5-011-ModelingIbuprofren-ModelingScenario
    We consider modeling of data from a clinical experiment administered as oral doses of 400 mg ibuprofen, an analgesic pain reliever. Concentrations of ibuprofen in the serum/plasma of the subjects were recorded after the initial ingestion of the...
    dataAICAkaike Information Criterionabsorptionsum of square errorscompartment modelibuprofendelay
    Modeling Scenario
    336

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    537

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    1-132-DigoxinElimination-ModelingScenario
    We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
    nullclinespharmacokineticsdigoxindrug eliminationtwo compartment
    Potential Scenario
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    2004-Ledzewicz-Schattler-Application of Control Theory in Modelling Cancer Chemotherapy
    In this paper we discuss how to incorporate more realistic medical aspects of chemotherapy which hitherto have been neglected in the models.
    optimal controldrug resistancepharmacokineticspharmacodynamicschemotherapy
    Potential Scenario
    103

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    2012-Shargel-Yu-AccessPharmacy-Applied Biopharmaceutics and Pharmacokinetics
    Step by step formation of drug absorption models is shown with many good graphics of system and plots. Solutions are offered but no solution methods are shown.
    Michaelis-MentenEnzymesubstratecompartmentpharmacokineticsrate constanturinary dataabsorption rate
    Potential Scenario
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    2010-Shianga-EtAl-Computational model of the human glucose-insulin regulatory system
    A computational model of insulin secretion and glucose metabolism for assisting the diagnosis of diabetes mellitus in clinical research is introduced. The
    glucose tolerance testsum of squared residualsmultiple shooting methodcost function
    Free Online Textbook
    189

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    2012-Vivek_Patel-Chemical Kinetics
    The book is designed to help the reader, particularly students, researchers, research scholars, scientists, chemists and industry fraternity of chemistry and allied fields; understand the mechanics and reactions rates.
    kineticschemistryreaction
    Free Online Textbook
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    1991-Carmine_Chicone-Ordinary Differential Equations with Applications
    This is a complete text for a graduate level course. Hence there is much theory, but there is a chapter on applications with some sophisticated approaches and high level modeling of motion.
    orbitstwo mass systematommagnetic fieldcoupled penduluminverted pendulumcharged particleKepler motion
    Potential Scenario
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    2012-Greer-Palin-Students in Differential Equations and Epidemiology Model a Campus Outbreak of pH1N1
    We describe a semester-long collaboration between a mathematics class and a biology class. Students worked together to understand and model the trajectory of the pandemic H1N1, pH1N1, outbreak across campus in fall 2009.
    H1N1pandemicspreadoutbreakpH1N1
    Modeling Scenario
    1093

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    179

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    3-051-ProjectileMotions-ModelingScenario
    We consider several instances of projectile flight without resistance, one on level ground and one from edge of cliff to determine maximum distance and placement.
    trajectorylaunching radiantprojectile motionprojectileno resistanceangle of launch