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Views
Date
Relevance
Potential Scenario
140
views
50
downloads
0
comments
1975-Rodda-Sampson-Smith-The One-Compartment Open Model Parameter Estimation
A new estimation procedure is proposed for estimating the parameters of the simplest pharmacokinetic model, the one-compartment open model.
compartment model
pharmacokinetics
nonlinear estimation
one compartment model
Modeling Scenario
470
views
191
downloads
0
comments
5-012-LipoproteinModeling-ModelingScenario
Data from a study on the amounts of low-density-lipoprotein (LDL), form of cholesterol, in blood plasma is presented. Students build, validate, and use a compartment model of the kinetic exchange of the LDL between body tissue and blood plasma.
wildlife
low-density-lipoprotein
tracer
compartment model
cholesterol
blood plasma
body tissue
Modeling Scenario
349
views
198
downloads
0
comments
5-022-ColdPill-ModelingScenario
A model for the flow of a cold pill drug through the gastrointestinal compartment to the bloodstream compartment of a human subject is proposed. Students solve the system of differential equation model, use known parameter values, and plot solutions.
rates
medicine
drug discovery
compartment
cold pill
gastrointestinal
bloodstream
Potential Scenario
195
views
69
downloads
0
comments
2017-GR_Gustafson-Differential Equations Course Materials
There are many applications from compartment and cascade analysis, recycling brine tank, home heating with multiple rooms, chemostat, microbes, heartbeats, lidocaine, nutrient flow in an aquarium, biomass transfer, pesticides, forecasting prices,...
chemostat
microbes
biomass
forecasting
transfer
compartment
pesticides
earthquake
tank
heating
lidocaine
brine
heartbeats
nutrient flow
aquarium
electric networks
circuits
logging
building
cascade
Modeling Scenario
1164
views
5459
downloads
0
comments
5-001-LSD-ModelingScenario
We describe the use of a two compartment model of a linear system of first order linear differential equations to model lysergic acid diethylamide (LSD) in the body. We provide the data from the literature.
LSD
Spanish
compartment
pharmacokinetics
lysergic acid diethylamide
Potential Scenario
176
views
72
downloads
0
comments
1996-D_Erdman-MM_Morelock-A Study of Kinetics
This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
simulation
kinetics
parameter estimation
Enzyme
substrate
savings
compartment
stomach
blood
ginseng
Modeling Scenario
278
views
211
downloads
0
comments
1-086-MedicinalPill-ModelingScenario
Administration of a medicinal pill in single and multiple doses is modeled.
medicine
spillover
compartment
bloodstream
GIT-Track
Modeling Scenario
327
views
521
downloads
0
comments
1-132-DigoxinElimination-ModelingScenario
We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
nullclines
pharmacokinetics
digoxin
drug elimination
two compartment
Potential Scenario
127
views
35
downloads
0
comments
2005-P_Howard-Modeling with ODE
In these notes we consider three critical aspects in the theory of ordinary differential equations: developing models of physical phenomena, mathematically well-posed, solving ODE numerically .
Fluid Mechanics
compartment
populations
variational methods
Hamiltonian mechanics
Potential Scenario
116
views
51
downloads
0
comments
2004-Aldo_Rescigno-On the use of pharmacokinetic models
In this paper I will define in a simple and logical way a set of useful pharmacokinetic parameters and show how their estimation depends on the assumed model.
compartment
steady state
pharmacokinetics
volume distribution
Modeling Scenario
303
views
219
downloads
0
comments
1-085-DrugBolus-ModelingScenario
Given data on the concentration of a drug in the plasma of a human in mg/L at certain time intervals in hours can we determine the rate at which the drug leaves the plasma as well as the initial amount administered in a intravenous bolus of the drug?
concentration
sum of square errors
bolus
drug
rate constant
administer
Modeling Scenario
201
views
227
downloads
0
comments
5-020-ParacetamolAbsorption-ModelingScenario
We offer drug absorption data on paracetamol, an analgesic pain reliever, for two different sets of patients, vegetarian and non-vegetarian. Students build a two compartment model for plasma and non-plasma (tissue) compartments of human patients.
paracetamol
analgesic
vegetarian
non-vegetarian
Modeling Scenario
302
views
206
downloads
0
comments
1-051-OneTankSaltModel-ModelingScenario
A large tank initially contains 60 pounds of salt dissolved into 90 gallons of water. Salt water flows in at a rate of 4 gallons per minute, with a salt density of 2 pounds per gallon. The incoming water is mixed in with the contents of the tank...
compartment
salt
tank
mixing
flow
Modeling Scenario
307
views
450
downloads
0
comments
1-065-AlgalBlooms-ModelingScenario
This modeling scenario investigates the massive algal blooms that struck Lake Chapala, Mexico, starting in 1994.
direction fields
tool:dfield
algae
harmful algae blooms
population
compartment
Lake Chapala
Modeling Scenario
208
views
204
downloads
0
comments
1-134-LanguageDynamics-ModelingScenario
Students will be introduced to a mathematical model for language dynamics. Specifically, the model describes the change in the fraction of a population speaking one language over another.
language
compartment
phase lines
bifurcation
switching
Modeling Scenario
459
views
476
downloads
0
comments
1-042-KoolAid-ModelingScenario
Students run experiments involving concentrated solution of drink powder flowing from upper to lower tank, initially filled with plain water. They make qualitative observations about the intensity of the color in the tanks, record data, and build...
concentration
compartment
tanks
KoolAid
Modeling Scenario
633
views
373
downloads
0
comments
5-011-ModelingIbuprofren-ModelingScenario
We consider modeling of data from a clinical experiment administered as oral doses of 400 mg ibuprofen, an analgesic pain reliever. Concentrations of ibuprofen in the serum/plasma of the subjects were recorded after the initial ingestion of the...
data
AIC
Akaike Information Criterion
absorption
sum of square errors
compartment model
ibuprofen
delay
Modeling Scenario
569
views
312
downloads
0
comments
6-020-AlgaePopulationSelf-Replenishment-ModelingScenario
This modeling scenario investigates the massive algal blooms that struck Lake Chapala, Mexico, in 1994. A
algae
population
Mexico
qualitative
compartment
linearization
Jacobian
lak
nondimensionalization
pplane
Modeling Scenario
213
views
228
downloads
0
comments
6-029-TumorGrowth-ModelingScenario
This modeling scenario guides a student familiar with single ordinary differential equation (ODE) models towards the development of a more complex system of two ODEs for describing the evolution of tumor growth over time.
Pop_Growth Pilot
logistic
comparment
tumor
synthetic data
sum of squares error
Modeling Scenario
274
views
186
downloads
0
comments
1-025-MixingItUp-ModelingScenario
Students build three different models for levels of salt in a tank of water and at each stage the level of complexity increases with attention to nuances necessary for success.
compartment
salt
tank
mixing
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