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Views
Date
Relevance
Modeling Scenario
374
views
91
downloads
0
comments
6-017-OncolyticViruses-ModelingScenario
Students explore oncolytic virotherapy using systems of differential equations and numerical simulations.
cancer
cancer-immune dynamics
immune suppressor drug
oncolytic virus
virotherapy
Modeling Scenario
235
views
141
downloads
0
comments
1-085-DrugBolus-ModelingScenario
Given data on the concentration of a drug in the plasma of a human in mg/L at certain time intervals in hours can we determine the rate at which the drug leaves the plasma as well as the initial amount administered in a intravenous bolus of the drug?
concentration
sum of square errors
bolus
drug
rate constant
administer
Modeling Scenario
180
views
96
downloads
0
comments
1-080-DrugAdministration-ModelingScenario
A simple drug administration situation is modeled with only two observations.
decay
bloodstream
drug
rate constant
administer
Modeling Scenario
261
views
120
downloads
0
comments
5-022-ColdPill-ModelingScenario
A model for the flow of a cold pill drug through the gastrointestinal compartment to the bloodstream compartment of a human subject is proposed. Students solve the system of differential equation model, use known parameter values, and plot solutions.
rates
medicine
drug discovery
compartment
cold pill
gastrointestinal
bloodstream
Modeling Scenario
147
views
30
downloads
0
comments
1-131-CaffeineElimination-ModelingScenario
We model the concentration of caffeine eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
caffeine
elimination
pharmacokinetics
drug
Modeling Scenario
214
views
154
downloads
0
comments
1-130-AspirinAbsorption-ModelingScenario
We model the amount of aspirin absorbed by the human body at a constant rate. This is a ``zero-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
pharmacokinetics
drug
aspirin
Modeling Scenario
284
views
390
downloads
0
comments
1-132-DigoxinElimination-ModelingScenario
We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
nullclines
pharmacokinetics
digoxin
drug elimination
two compartment
Modeling Scenario
335
views
184
downloads
0
comments
1-138-InnerEarDrugDelivery-ModelingScenario
Students examine local drug delivery to the cochlea. The delivery system is modeled as a liquid mixing problem. Students formulate the differential equation, and solve the equation using separation of variables or integrating factor.
concentration
drug delivery
inner ear
cochlea
hearing loss
Potential Scenario
123
views
39
downloads
0
comments
1971-Boyes-Scott-Jebson-Godman-Julian-Lidocaine in Man
Plasma levels of lidocaine were measured in 5 normal male volunteers following both intravenous and oral administration of the drug.
p
Pharmacology
pharmacokinetics
lidocaine
Modeling Scenario
562
views
298
downloads
0
comments
5-011-ModelingIbuprofren-ModelingScenario
We consider modeling of data from a clinical experiment administered as oral doses of 400 mg ibuprofen, an analgesic pain reliever. Concentrations of ibuprofen in the serum/plasma of the subjects were recorded after the initial ingestion of the...
data
AIC
Akaike Information Criterion
absorption
sum of square errors
compartment model
ibuprofen
delay
Modeling Scenario
165
views
181
downloads
0
comments
5-020-ParacetamolAbsorption-ModelingScenario
We offer drug absorption data on paracetamol, an analgesic pain reliever, for two different sets of patients, vegetarian and non-vegetarian. Students build a two compartment model for plasma and non-plasma (tissue) compartments of human patients.
paracetamol
analgesic
vegetarian
non-vegetarian
Potential Scenario
174
views
61
downloads
0
comments
2014-Eckhoff-EtAl-Fun with maths-exploring implications of mathematical models for malaria eradication
. In this note, four examples demonstrate both the effects of model structures and assumptions and also the benefits of using a diversity of model approaches fomalaria eradication strategies.
vaccine
malaria
migration
eradication
seasonality
Potential Scenario
153
views
41
downloads
0
comments
1996-D_Erdman-MM_Morelock-A Study of Kinetics
This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
simulation
kinetics
parameter estimation
Enzyme
substrate
savings
compartment
stomach
blood
ginseng
Modeling Scenario
261
views
114
downloads
0
comments
1-115-ModelingWithFirstOrderODEs-ModelingScenario
Several models using first order differential equations are offered with some questions on formulating a differential equations model with solutions provided.
bacteria
falling object
Newton's Law of Cooling
drug
cooling
drag
Modeling Scenario
207
views
111
downloads
0
comments
3-027-BobbingDropping-ModelingScenario
We present two exercises in which we ask students to model (1) falling object experiencing terminal velocity and (2) bobbing block of wood in liquid. We model the motion using Newton's Second Law of Motion and Archimedes' Principle.
drug resistance
directed
buoyancy
free fall
static equilibrium
displacement
Modeling Scenario
125
views
98
downloads
0
comments
6-003-SchoolFluEpidemic-ModelingScenario
We offer a model of the spread of flu in a school dormitory and are asked to find when the flu levels reach their peak and explain long term behavior of the spread of the flu.
infection
epidemic
SIR model
flu
peak
school children
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