Skip to Main Content
Powered by QUBES

Resources

Text Search:
Applied Filters
    Potential Scenario
    280

    views

    70

    downloads

    0

    comments

    1968-Wagner-Aghajanian-Bing-Correlation of performance test scores with tissue concentration of lysergic acid diethylamide
    This paper offers a two compartment model of lysergic acid diethylamide (LSD) in volunteer students and through parameter estimation models the amount of LSD in the tissue after its initial administration through the plasma.
    LSDcorrelation coefficientcompartment modellysergic acid diethylamideperformancetest scoretissue concentration
    Modeling Scenario
    336

    views

    537

    downloads

    0

    comments

    1-132-DigoxinElimination-ModelingScenario
    We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
    nullclinespharmacokineticsdigoxindrug eliminationtwo compartment
    Potential Scenario
    142

    views

    59

    downloads

    0

    comments

    2006-Han-EtAl-Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology
    Physiologically-based pharmacokinetic (PBPK) models have been used to describe the distribution and elimination characteristics of intravenous ethanol administration.
    liverwortsintraveneouspharmacokineticsethanolethanol infustionpharmacodynamictissue model
    Potential Scenario
    167

    views

    68

    downloads

    0

    comments

    2003-Richard-Carson-Tracer kinetic modeling in PET
    The use of radiopharmaceuticals and the imaging of their biodistribution and kinetics with modern instrumentation are key components to successful developments in PET.
    Metabolismtomographyradiopharmaceuticalspositron emission
    Potential Scenario
    182

    views

    50

    downloads

    0

    comments

    2012-Jambhekar-Breen-Extravascular Routes Of Drug Administration in Basic Pharamacokinetics
    This provides an excellent step-by-step of the physiology, construction of model, and notions like peak concentration as well as issues like lag time.
    concentrationphysiologydrugslag timeExtravascularPharamacokineticspeak time
    Potential Scenario
    161

    views

    46

    downloads

    0

    comments

    1989-EY_Rodin-S_Jaques-Countercurrent Oxygen Exchange in the Swim Bladders of Deep-Sea Fish
    Oxygen diffuses from lungs into blood, nutrients diffuse from intestinal tracts into blood and from blood into various cells, and waste products diffuse from cells back into blood.
    fishCell Membraneflowbloodbladdercountercurrent
    Potential Scenario
    196

    views

    70

    downloads

    0

    comments

    2015-Valerie_Billard-Pharmacokinetic-pharmacodynamic relationship of anesthetic drugs - from modeling to clinical use
    The purpose of this short review is to describe the basis of pharmacokinetics and modeling, the concentration-effects relationship, and drug interactions modeling to offer to anesthesiologists and non-anesthesiologists an overview of the rules to...
    anesthesiapharmacokineticspharmacodynamicanesthetic
    Potential Scenario
    140

    views

    80

    downloads

    0

    comments

    2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
    This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
    absorptioncompartmentbloodstreamplasmapharmacokineticspharmacodynamicstherapeutic concentration rangedrug dispositiondrug response
    Potential Scenario
    153

    views

    52

    downloads

    0

    comments

    2004-Jones-Song-Thomas-Controlling wound healing through debridement
    In this article, a system of differential equations that models slough/wound interaction is developed.
    bacteriawound healinghealingderidingisocline
    Potential Scenario
    173

    views

    65

    downloads

    0

    comments

    1964-Aghajanian-Bing-Persistence Of LSD In Plasma In Human Subjects
    Two micrograms per kilogram of LSD-25 was administered intravenously to five normal human subjects. The concentration of[ drug in plasma was determined serially over the subsequent 8 hours. We model this.
    LSDscoreplasmalysergic acid diethylamidehuman subjuects
    Potential Scenario
    133

    views

    56

    downloads

    0

    comments

    2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
    This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
    absorptioncompartmentbloodstreamplasmapharmacokineticsdrugpharmacodynamics
    Potential Scenario
    276

    views

    75

    downloads

    0

    comments

    2014-Blomhøj-EtAl-Compartment models
    An overview of compartment models with many rich illustrations and much attention to various numerical methods in solutions of the resulting differential equations using Matlab. Also included is a section on the limitations of compartment models.
    concentrationkineticsphysiologycompartmentsalttankbalancereactionsminkbathtub
    Potential Scenario
    200

    views

    89

    downloads

    0

    comments

    1957-Axelrod_ Brady_Witkop_Evarts-The Distribution and Metabolism of Lysergic Acid Diethylamide
    The development of a specific and sensitive method for the estimation of LSD in biological materials has enabled us to study the tissue distribution, excretion, rate of biotransformation, and metabolism of the drug, as well as the subcellular...
    mathematical modeldataLSDMetabolismbloodstreamlysergic acid diethylamidedistribution
    Potential Scenario
    1248

    views

    47

    downloads

    0

    comments

    2000-Erdman-Morelock-A Study of Kinetics The Estimation and Simulation of Systems of First-Order Differential Equations
    This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
    kineticsSAScompartmentpharmacokinetics
    Potential Scenario
    184

    views

    74

    downloads

    0

    comments

    1996-D_Erdman-MM_Morelock-A Study of Kinetics
    This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
    simulationkineticsparameter estimationEnzymesubstratesavingscompartmentstomachbloodginseng
    Technique Narrative
    397

    views

    204

    downloads

    0

    comments

    9-001-SkinBurnModelNumericalMethods-TechniqueNarrative
    The heat equation is an important partial differential equation (PDE) which describes the distribution of heat in a given region over time. Numerical methods play an important role in solving these.
    Maternal-Fetal interfaceheat equationConservation of Energytheat fluxEuler's forward methodcentral differenceskin burnhyperthermiathermal conductivitylayers
    Potential Scenario
    149

    views

    76

    downloads

    0

    comments

    2004-Ledzewicz-Schattler-Application of Control Theory in Modelling Cancer Chemotherapy
    In this paper we discuss how to incorporate more realistic medical aspects of chemotherapy which hitherto have been neglected in the models.
    optimal controldrug resistancepharmacokineticspharmacodynamicschemotherapy
    Potential Scenario
    136

    views

    73

    downloads

    0

    comments

    2016-Erno_Keszei-Chemical Kinetics for Beginners
    The most important goal of kinetic research is the identification and characterisation of elementary molecular events which make possible the transformation of reactants into products.
    kineticszeroth order reactionfirst order reactionsecond order reactionreaction ratesthird order reaction
    Potential Scenario
    171

    views

    44

    downloads

    0

    comments

    2015-Sivakumar-EtAl-Approximate Analytical Expression of Concentrations in a Kinetic Model for Biogas Generation from Banana Waste
    The initial value problem in a kinetic model for biogas generation from banana waste is discussed. The model involves the system of non-linear differential equations which has variety of non-linear rate function.
    chemical kineticsMichaelis-Menten kineticsanaerobic digestionacidogenic stepsbananamethanogenic stepswastes
    Modeling Scenario
    472

    views

    477

    downloads

    0

    comments

    1-042-KoolAid-ModelingScenario
    Students run experiments involving concentrated solution of drink powder flowing from upper to lower tank, initially filled with plain water. They make qualitative observations about the intensity of the color in the tanks, record data, and build...
    concentrationcompartmenttanksKoolAid