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Downloads
Views
Date
Relevance
Potential Scenario
147
views
51
downloads
0
comments
2006-Loyd-Wodarz-Drug Resistance in Acute Viral Infections-Rhinovirus as a Case Study
We develop an epidemiological model that can be used to address the spread of resistance at the population level, and a virus dynamics model that can be used to study the dynamics of virus over the time course of an individual’s infection.
stability
resistance
virus
drug
epidemic competition
immune response
rhinovirus
Potential Scenario
140
views
45
downloads
0
comments
2008-Huangi-Lu-Modeling long-term longitudinal HIV dynamics with applications to an AIDS clinical study
To better understand the factors responsible for the virological failure, this paper develops the mechanism-based nonlinear differential equation models for characterizing long-term viral dynamics with ARV therapy.
longitudinal data
AIDS
antiretroviral drug therapy
Bayesian nonlinear mixed-effects
time-varying drug efficacy
HIV dynamics
Potential Scenario
149
views
76
downloads
0
comments
2004-Ledzewicz-Schattler-Application of Control Theory in Modelling Cancer Chemotherapy
In this paper we discuss how to incorporate more realistic medical aspects of chemotherapy which hitherto have been neglected in the models.
optimal control
drug resistance
pharmacokinetics
pharmacodynamics
chemotherapy
Potential Scenario
191
views
44
downloads
0
comments
1994-Roland_Minton-A Progression of Projectiles-Examples from Sports
There is a progression of complexity and issues in projectile motion modeling from no resistance, to resistance proportional to velocity, then to velocity squared,
sports
resistance
projectile
baseball
drag
linear resistance
quadratic resistance
tennis
Potential Scenario
182
views
50
downloads
0
comments
2012-Jambhekar-Breen-Extravascular Routes Of Drug Administration in Basic Pharamacokinetics
This provides an excellent step-by-step of the physiology, construction of model, and notions like peak concentration as well as issues like lag time.
concentration
physiology
drugs
lag time
Extravascular
Pharamacokinetics
peak time
Potential Scenario
103
views
38
downloads
0
comments
2012-Shargel-Yu-AccessPharmacy-Applied Biopharmaceutics and Pharmacokinetics
Step by step formation of drug absorption models is shown with many good graphics of system and plots. Solutions are offered but no solution methods are shown.
Michaelis-Menten
Enzyme
substrate
compartment
pharmacokinetics
rate constant
urinary data
absorption rate
Potential Scenario
140
views
80
downloads
0
comments
2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
absorption
compartment
bloodstream
plasma
pharmacokinetics
pharmacodynamics
therapeutic concentration range
drug disposition
drug response
Potential Scenario
143
views
46
downloads
0
comments
2005-Minna_Wedenberg-Pharmacokinetic modeling of gastric emptying
The development of new drug substances is a complex, time consuming and expensive process. Reducing the time for drug development and avoiding late termination of candidate drugs are important challenges for the pharmaceutical industry.
paracetamol
pharmacokinetics
stomach
small intestine
sulfapyridine
Potential Scenario
133
views
56
downloads
0
comments
2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
absorption
compartment
bloodstream
plasma
pharmacokinetics
drug
pharmacodynamics
Potential Scenario
152
views
48
downloads
0
comments
1999-Peter_Deuflhard-Differential Equations in Technology and Medicine
It deals with a variety of challenging real life problems selected from clinical cancer therapy, communication technology, polymer production, and pharmaceutical drug design.
cancer
design
tumor
drug
polymer
therapy
Potential Scenario
196
views
70
downloads
0
comments
2015-Valerie_Billard-Pharmacokinetic-pharmacodynamic relationship of anesthetic drugs - from modeling to clinical use
The purpose of this short review is to describe the basis of pharmacokinetics and modeling, the concentration-effects relationship, and drug interactions modeling to offer to anesthesiologists and non-anesthesiologists an overview of the rules to...
anesthesia
pharmacokinetics
pharmacodynamic
anesthetic
Potential Scenario
139
views
44
downloads
0
comments
2002-Chai-Optimal initial angle to fire a projectile
Assume a projectile is fired without air resistance and lands at a height y above its initial vertical position. What is the optimal initial angle of firing to maximize the horizontal distance traveled by the projectile?”
optimization
projectile motion
launch angle
Potential Scenario
148
views
48
downloads
0
comments
2011-Nguyen-Shi-Modeling the absorption circulation and metabolism of tirapazamine
This apparently is a student project and it develops the kinetic model, uses Matlab for numerical solution, analytic solution and numerical solution.
absorption
Michaelis-Menten
Metabolism
drug metabolism
circulation
Potential Scenario
254
views
91
downloads
0
comments
2018-David_Bourne-Pharmacokinetics – Source Material
This is a rich source of pharmacokinetics modeling activities and data. These are syllabus notes with homework assignments listed.
bolus
pharmacokinetics
pharmacodynamic
drug distribution
Potential Scenario
208
views
89
downloads
0
comments
1971-Carl_Metzler-Usefulness Of Two Compartment Open Model In Pharmacokinetics
Compartment models are widely used in pharmaceutical research to quantitate the kinetics of absorption, distribution, metabolism and excretion of a drug. In this article two applications of the two compartment open model are discussed.
LSD
compartment
pharmacokinetics
Potential Scenario
200
views
89
downloads
0
comments
1957-Axelrod_ Brady_Witkop_Evarts-The Distribution and Metabolism of Lysergic Acid Diethylamide
The development of a specific and sensitive method for the estimation of LSD in biological materials has enabled us to study the tissue distribution, excretion, rate of biotransformation, and metabolism of the drug, as well as the subcellular...
mathematical model
data
LSD
Metabolism
bloodstream
lysergic acid diethylamide
distribution
Potential Scenario
168
views
59
downloads
0
comments
2017-CW_Groetsch-Hammer and Feather - Some Calculus of Mass and Fall Time
Does a heavy object fall faster than a lighter one? In 1971 NASA astronaut Dave Scott, Commander of the Apollo 15 lunar mission, used a hammer and a falcon feather on the surface of the moon to give a dramatic illustration that this is not so.
gravity
free fall
linear resistance
quadratic resistance
hammer
feather
Moon resistance
Galileo
Potential Scenario
132
views
48
downloads
0
comments
1987-MS_Greenwood-Using videotapes to study underdamped motion of a pendulum
Using a video camera to study the effects of air resistance acting on pendulum bob, ping-pong ball, styrofoam spheres, and brass spheres.
Video
resistance
pendulum
ping-pong ball
styrofoam ball
brass ball
Potential Scenario
222
views
52
downloads
0
comments
1999-Khorasheh-Ahmadi-Gerayeli-Application of Direct Search Optimization for Pharmacokinetic Parameter Estimation
For simple pharmacokinetic compartmental models, analytical solution to the governing differential equations provide a mean to evaluate the associated rate constants. Such methods, however, can not be used used for more complex multi-compartment...
sum of square errors
least squares
pharmacokinetics
lineteics
compartmental models
direct search
Potential Scenario
164
views
44
downloads
0
comments
1971-Boyes-Scott-Jebson-Godman-Julian-Lidocaine in Man
Plasma levels of lidocaine were measured in 5 normal male volunteers following both intravenous and oral administration of the drug.
p
Pharmacology
pharmacokinetics
lidocaine
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