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Downloads
Views
Date
Relevance
Potential Scenario
212
views
50
downloads
0
comments
1967-JG-Wagner-Computers in pharmacokinetics
This is a seminal paper in pharmacokinetics in which the author introduces historic notions and approaches. As can be seen from the abstract there is a variety of material here.
kinetics
computers
pharmacokinetics
Potential Scenario
123
views
52
downloads
0
comments
2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
absorption
compartment
bloodstream
plasma
pharmacokinetics
drug
pharmacodynamics
Potential Scenario
128
views
74
downloads
0
comments
2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
absorption
compartment
bloodstream
plasma
pharmacokinetics
pharmacodynamics
therapeutic concentration range
drug disposition
drug response
Potential Scenario
238
views
83
downloads
0
comments
2018-David_Bourne-Pharmacokinetics – Source Material
This is a rich source of pharmacokinetics modeling activities and data. These are syllabus notes with homework assignments listed.
bolus
pharmacokinetics
pharmacodynamic
drug distribution
Potential Scenario
151
views
44
downloads
0
comments
1969-Carl_Metzler-A mathematical model for the pharmacokinetics of LSD effect
Contains data on performance scores vs. plasma levels of LSD in human tissues.
LSD
testing
pharmacokinetics
performance
plasma level
Potential Scenario
178
views
82
downloads
0
comments
1971-Carl_Metzler-Usefulness Of Two Compartment Open Model In Pharmacokinetics
Compartment models are widely used in pharmaceutical research to quantitate the kinetics of absorption, distribution, metabolism and excretion of a drug. In this article two applications of the two compartment open model are discussed.
LSD
compartment
pharmacokinetics
Potential Scenario
121
views
43
downloads
0
comments
2011-GA_Koch-Noble-Drugs in the Classroom Using Pharmacokinetics to Introduce Biomathematical Modeling
By beginning with simple model involving the half-life of a drug, students take advantage of their mathematical abilities to explore the biology.
Biomathematics
pharmacokinetics
Potential Scenario
295
views
48
downloads
0
comments
1976-JG-Wagner-Computers in pharmacokinetics
This is a seminal paper in pharmacokinetics in which the author introduces historic notions and approaches. As can be seen from the abstract there is a variety of material here.
kinetics
computer
parameters
Pharmacology
drugs
pharmacokinetics
Potential Scenario
96
views
35
downloads
0
comments
2012-Shargel-Yu-AccessPharmacy-Applied Biopharmaceutics and Pharmacokinetics
Step by step formation of drug absorption models is shown with many good graphics of system and plots. Solutions are offered but no solution methods are shown.
Michaelis-Menten
Enzyme
substrate
compartment
pharmacokinetics
rate constant
urinary data
absorption rate
Potential Scenario
184
views
64
downloads
0
comments
2015-Valerie_Billard-Pharmacokinetic-pharmacodynamic relationship of anesthetic drugs - from modeling to clinical use
The purpose of this short review is to describe the basis of pharmacokinetics and modeling, the concentration-effects relationship, and drug interactions modeling to offer to anesthesiologists and non-anesthesiologists an overview of the rules to...
anesthesia
pharmacokinetics
pharmacodynamic
anesthetic
Potential Scenario
124
views
51
downloads
0
comments
2019-Radulescu-Lundgren-A_pharmacokinetic_model_of_lead_absorption_and_calcium_competitive_dynamics
We build and analyze a compartmental model of lead pharmacokinetics, focused specifically on addressing neurotoxicity.
QUBES Leadership Team
parameters
absorption
bifurcation
pharmacokinetics
calcium
cognitive decline
Potential Scenario
186
views
99
downloads
0
comments
2018-LA_Peletier-Ordinary Differential Equations in Pharmacodynamics
Good mix of theory, application, solution technique in a number of areas of applications of differential equations. Develops qualitative behavior issues. Exercises, but not about models, more about the mathematics only.
compartment model
pharmacokinetics
pharmacodynamics
orbits
turnover
Potential Scenario
135
views
68
downloads
0
comments
2004-Ledzewicz-Schattler-Application of Control Theory in Modelling Cancer Chemotherapy
In this paper we discuss how to incorporate more realistic medical aspects of chemotherapy which hitherto have been neglected in the models.
optimal control
drug resistance
pharmacokinetics
pharmacodynamics
chemotherapy
Potential Scenario
125
views
49
downloads
0
comments
2006-Han-EtAl-Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology
Physiologically-based pharmacokinetic (PBPK) models have been used to describe the distribution and elimination characteristics of intravenous ethanol administration.
liverworts
intraveneous
pharmacokinetics
ethanol
ethanol infustion
pharmacodynamic
tissue model
Potential Scenario
203
views
48
downloads
0
comments
1999-Khorasheh-Ahmadi-Gerayeli-Application of Direct Search Optimization for Pharmacokinetic Parameter Estimation
For simple pharmacokinetic compartmental models, analytical solution to the governing differential equations provide a mean to evaluate the associated rate constants. Such methods, however, can not be used used for more complex multi-compartment...
sum of square errors
least squares
pharmacokinetics
lineteics
compartmental models
direct search
Potential Scenario
152
views
40
downloads
0
comments
1971-Boyes-Scott-Jebson-Godman-Julian-Lidocaine in Man
Plasma levels of lidocaine were measured in 5 normal male volunteers following both intravenous and oral administration of the drug.
p
Pharmacology
pharmacokinetics
lidocaine
Potential Scenario
108
views
49
downloads
0
comments
2004-Aldo_Rescigno-On the use of pharmacokinetic models
In this paper I will define in a simple and logical way a set of useful pharmacokinetic parameters and show how their estimation depends on the assumed model.
compartment
steady state
pharmacokinetics
volume distribution
Potential Scenario
125
views
77
downloads
0
comments
2014-Wang-EtAl-Estimating Mixed-Effects Differential Equation Models
When multiple replicates of measurements are available for the dynamic process, it is of great interest to estimate mixed-effects in the ODE model for the process. We propose a semiparametric method to estimate mixed-effects ODE models.
pharmacokinetics
dynamic models
smoothing
spline
mixed-effects models
HiV combination therapy
Potential Scenario
150
views
79
downloads
0
comments
2009-Su-EtAl-Fitting Compartmental Models to Multiple Dose Pharmacokinetic Data using SAS
In the case of a multiple dose study where subjects experience different dosing times, a superposition principle can be used to recursively account for each additional dose.
SAS
superposition
pharmacokinetics
compartmental models
multiple dose
Potential Scenario
132
views
48
downloads
0
comments
1975-Rodda-Sampson-Smith-The One-Compartment Open Model Parameter Estimation
A new estimation procedure is proposed for estimating the parameters of the simplest pharmacokinetic model, the one-compartment open model.
compartment model
pharmacokinetics
nonlinear estimation
one compartment model
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