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    Potential Scenario
    161

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    1989-EY_Rodin-S_Jaques-Countercurrent Oxygen Exchange in the Swim Bladders of Deep-Sea Fish
    Oxygen diffuses from lungs into blood, nutrients diffuse from intestinal tracts into blood and from blood into various cells, and waste products diffuse from cells back into blood.
    fishCell Membraneflowbloodbladdercountercurrent
    Potential Scenario
    197

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    1977-Michael_Mackey-Leon_Glass-Oscillation and Chaos in Physiological Control Systems
    First-order nonlinear differential-delay equations describing physiological control systems are studied. The equations display a broad diversity of dynamical behavior including limit cycle oscillation.
    sensitivitychaosparametersRespirationdelayblood cells
    Potential Scenario
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    2014-Wrona-EtAl-Two-compartment model as a teaching tool for cholesterol homeostasis
    To investigate cholesterol transport in the circulatory system, we have previously developed a two-compartment mathematical model. Here, we show how this model can be used as a teaching tool for cholesterol homeostasis.
    metabolic syndromecompartment modelcholesterolhigh blood cholesterol
    Potential Scenario
    238

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    57

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    2011-Radouane_Yafia-A Study of Differential Equations Modeling Malignant Tumor Cells in Competition with Immune System
    In this paper, we present a competition model of malignant tumor growth that includes the immune system response. The model considers two populations: immune system (effector cells) and population of tumor (tumor cells).
    Immunologytumorhopf bifrucation
    Potential Scenario
    205

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    57

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    1986-Istvan_Gyori-Connections between compartment systems pipes and integro-differential equations
    In this paper we give the mathematical description of models in which the mass transport between compartments requires a given definite time or transit times are distributed according to given probability distribution functions.
    physiologypipelinecompartmentbloodcirculationintegro-differential equation
    Potential Scenario
    173

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    69

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    2002-Nelson-Perelson-Mathematical analysis of delay differential equations models of HIV-1 infection
    We develop and analyze a set of models that include intracellular delays, combination antiretroviral therapy, and the dynamics of both infected and uninfected T cells.
    infectionHIVT cells
    Modeling Scenario
    461

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    129

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    6-017-OncolyticViruses-ModelingScenario
    Students explore oncolytic virotherapy using systems of differential equations and numerical simulations.
    cancercancer-immune dynamicsimmune suppressor drugoncolytic virusvirotherapy
    Article or Presentation
    128

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    33

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    2002-Patrick_Nelson-Alan_Perelson-Mathematical_analysis_of_delay_differential _equation_models_of_HIV-1_infection
    Models of HIV-1 infection that include intracellular delays are more accurate representations of the biology and change the estimated values of kinetic parameters when compared to models without delays.
    delayHIV-1T cellscombination antiviral therapy
    Potential Scenario
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    52

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    2007-Exben_Friis-Jensen-Modeling and Simulation of Glucose-Insulin Metabolism
    In this thesis one of the models of diabetes, Bergman’s minimal model is described trough derivation and simulations.
    Metabolisminsulin resistanceglucosePID controllerintolerance
    Potential Scenario
    134

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    52

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    2019-Radulescu-Lundgren-A_pharmacokinetic_model_of_lead_absorption_and_calcium_competitive_dynamics
    We build and analyze a compartmental model of lead pharmacokinetics, focused specifically on addressing neurotoxicity.
    QUBES Leadership Teamparametersabsorptionbifurcationpharmacokineticscalciumcognitive decline
    Modeling Scenario
    309

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    228

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    1-085-DrugBolus-ModelingScenario
    Given data on the concentration of a drug in the plasma of a human in mg/L at certain time intervals in hours can we determine the rate at which the drug leaves the plasma as well as the initial amount administered in a intravenous bolus of the drug?
    concentrationsum of square errorsbolusdrugrate constantadminister
    Potential Scenario
    158

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    51

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    2018-Winkle-Igoshin-Bennett-Josic-Ott-Modeling_Mechanical_Interactions_in_Growing_Populations_of_Rod-Shaped_Bacteria
    Here, we present an agent-based model that allows growing cells to detect and respond to mechanical interactions.
    bacteriaagent-basedpopulationbrod-shapedcellular growth
    Potential Scenario
    141

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    79

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    2015-Khan-EtAl-How differential equations influence the tumor growth via mathematical models
    This work demonstrates the importance of differential equations to develop mathematical model of tumor growth.
    tumorcancdercancerous cellsimmunotherapymalignant
    Potential Scenario
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    70

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    2015-Valerie_Billard-Pharmacokinetic-pharmacodynamic relationship of anesthetic drugs - from modeling to clinical use
    The purpose of this short review is to describe the basis of pharmacokinetics and modeling, the concentration-effects relationship, and drug interactions modeling to offer to anesthesiologists and non-anesthesiologists an overview of the rules to...
    anesthesiapharmacokineticspharmacodynamicanesthetic
    Potential Scenario
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    2000-Erdman-Morelock-A Study of Kinetics The Estimation and Simulation of Systems of First-Order Differential Equations
    This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.
    kineticsSAScompartmentpharmacokinetics
    Potential Scenario
    161

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    82

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    2016-Bonin-EtAl-Mathematical modeling based on ordinary differential equations-vaccinology
    We developed a model of the immune response to vaccination against the yellow fever. Our simulations have shown consistent results when compared with experimental data available in the literature.
    Immunologyimmune systemAntigenvaccinologyyellow fever
    Potential Scenario
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    2003-Richard-Carson-Tracer kinetic modeling in PET
    The use of radiopharmaceuticals and the imaging of their biodistribution and kinetics with modern instrumentation are key components to successful developments in PET.
    Metabolismtomographyradiopharmaceuticalspositron emission
    Potential Scenario
    294

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    2018-Robert_Phair-Differential_equation_methods_for_simulation_of_GFP_kinetics_in_non–steady_state_experiments
    Here, we derive new tracer kinetic analytical methods for non–steady state biological systems by constructing mechanistic nonlinear differential equation models of the underlying cell biological processes.
    protein quality controlkineticsCellssteady statechemical kineticsfluouresencephotoactivationinytracellular
    Potential Scenario
    103

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    38

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    2012-Shargel-Yu-AccessPharmacy-Applied Biopharmaceutics and Pharmacokinetics
    Step by step formation of drug absorption models is shown with many good graphics of system and plots. Solutions are offered but no solution methods are shown.
    Michaelis-MentenEnzymesubstratecompartmentpharmacokineticsrate constanturinary dataabsorption rate
    Article or Presentation
    130

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    54

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    2011-Carl_Leinbach-Beyond_Newton_law_of_cooling_estimation_of_time_since_death
    The estimate of the time since death. Thus, the time of death is strictly that, an estimate. However, the time of death can be an important piece of information in some coroner’s cases, especially those that involve criminal or insurance...
    Newton's Law of Coolingtime of deathdouble exponentialcoroner