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Modeling Scenario
310
views
241
downloads
0
comments
7-010-MultipleDoses-ModelingScenario
Two multiple dose drug administration regimens are offered. A drug is to maintain a certain level (above a set minimum and below a set maximum) in the blood stream and one regimen involves bolus injections and another involves steady drip flow...
drug discovery
step function
dose
Dirac
drug administration
inverse Laplace Transform
intraveneous
bolus
steady drip
Modeling Scenario
232
views
116
downloads
0
comments
1-080-DrugAdministration-ModelingScenario
A simple drug administration situation is modeled with only two observations.
decay
bloodstream
drug
rate constant
administer
Modeling Scenario
312
views
231
downloads
0
comments
1-085-DrugBolus-ModelingScenario
Given data on the concentration of a drug in the plasma of a human in mg/L at certain time intervals in hours can we determine the rate at which the drug leaves the plasma as well as the initial amount administered in a intravenous bolus of the drug?
concentration
sum of square errors
bolus
drug
rate constant
administer
Modeling Scenario
356
views
207
downloads
0
comments
5-022-ColdPill-ModelingScenario
A model for the flow of a cold pill drug through the gastrointestinal compartment to the bloodstream compartment of a human subject is proposed. Students solve the system of differential equation model, use known parameter values, and plot solutions.
rates
medicine
drug discovery
compartment
cold pill
gastrointestinal
bloodstream
Modeling Scenario
344
views
130
downloads
0
comments
1-131-CaffeineElimination-ModelingScenario
We model the concentration of caffeine eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
caffeine
elimination
pharmacokinetics
drug
Modeling Scenario
261
views
185
downloads
0
comments
1-130-AspirinAbsorption-ModelingScenario
We model the amount of aspirin absorbed by the human body at a constant rate. This is a ``zero-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
pharmacokinetics
drug
aspirin
Modeling Scenario
337
views
537
downloads
0
comments
1-132-DigoxinElimination-ModelingScenario
We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
nullclines
pharmacokinetics
digoxin
drug elimination
two compartment
Modeling Scenario
408
views
287
downloads
0
comments
1-138-InnerEarDrugDelivery-ModelingScenario
Students examine local drug delivery to the cochlea. The delivery system is modeled as a liquid mixing problem. Students formulate the differential equation, and solve the equation using separation of variables or integrating factor.
concentration
drug delivery
inner ear
cochlea
hearing loss
Modeling Scenario
1182
views
5494
downloads
0
comments
5-001-LSD-ModelingScenario
We describe the use of a two compartment model of a linear system of first order linear differential equations to model lysergic acid diethylamide (LSD) in the body. We provide the data from the literature.
LSD
Spanish
compartment
pharmacokinetics
lysergic acid diethylamide
Modeling Scenario
652
views
398
downloads
0
comments
5-011-ModelingIbuprofren-ModelingScenario
We consider modeling of data from a clinical experiment administered as oral doses of 400 mg ibuprofen, an analgesic pain reliever. Concentrations of ibuprofen in the serum/plasma of the subjects were recorded after the initial ingestion of the...
data
AIC
Akaike Information Criterion
absorption
sum of square errors
compartment model
ibuprofen
delay
Modeling Scenario
293
views
231
downloads
0
comments
1-086-MedicinalPill-ModelingScenario
Administration of a medicinal pill in single and multiple doses is modeled.
medicine
spillover
compartment
bloodstream
GIT-Track
Modeling Scenario
211
views
242
downloads
0
comments
5-020-ParacetamolAbsorption-ModelingScenario
We offer drug absorption data on paracetamol, an analgesic pain reliever, for two different sets of patients, vegetarian and non-vegetarian. Students build a two compartment model for plasma and non-plasma (tissue) compartments of human patients.
paracetamol
analgesic
vegetarian
non-vegetarian
Modeling Scenario
464
views
131
downloads
0
comments
6-017-OncolyticViruses-ModelingScenario
Students explore oncolytic virotherapy using systems of differential equations and numerical simulations.
cancer
cancer-immune dynamics
immune suppressor drug
oncolytic virus
virotherapy
Modeling Scenario
303
views
187
downloads
0
comments
5-010-DNADegradation-ModelingScenario
We ask students to use the system of first order linear differential equations given in a source paper and estimates of the data from laboratory procedures from a plot to estimate the parameters and complete the modeling process.
DNA\kinetis
plasma
rat
pharmacokinetis
Modeling Scenario
338
views
139
downloads
0
comments
1-115-ModelingWithFirstOrderODEs-ModelingScenario
Several models using first order differential equations are offered with some questions on formulating a differential equations model with solutions provided.
bacteria
falling object
Newton's Law of Cooling
drug
cooling
drag
Modeling Scenario
249
views
143
downloads
0
comments
3-027-BobbingDropping-ModelingScenario
We present two exercises in which we ask students to model (1) falling object experiencing terminal velocity and (2) bobbing block of wood in liquid. We model the motion using Newton's Second Law of Motion and Archimedes' Principle.
drug resistance
directed
buoyancy
free fall
static equilibrium
displacement
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