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Modeling Scenario
308
views
239
downloads
0
comments
7-010-MultipleDoses-ModelingScenario
Two multiple dose drug administration regimens are offered. A drug is to maintain a certain level (above a set minimum and below a set maximum) in the blood stream and one regimen involves bolus injections and another involves steady drip flow...
drug discovery
step function
dose
Dirac
drug administration
inverse Laplace Transform
intraveneous
bolus
steady drip
Modeling Scenario
378
views
199
downloads
0
comments
1-016-DogDrugs-ModelingScenario
We offer a problem to determine the necessary drug administration in order to keep a dog sedated with specific information on half-life for an exponentially decaying presence of the drug in the body.
wild_dogs
drug discovery
half-life
pentobarbital sodium
anesthesia
Modeling Scenario
309
views
228
downloads
0
comments
1-085-DrugBolus-ModelingScenario
Given data on the concentration of a drug in the plasma of a human in mg/L at certain time intervals in hours can we determine the rate at which the drug leaves the plasma as well as the initial amount administered in a intravenous bolus of the drug?
concentration
sum of square errors
bolus
drug
rate constant
administer
Modeling Scenario
230
views
114
downloads
0
comments
1-080-DrugAdministration-ModelingScenario
A simple drug administration situation is modeled with only two observations.
decay
bloodstream
drug
rate constant
administer
Modeling Scenario
333
views
123
downloads
0
comments
1-131-CaffeineElimination-ModelingScenario
We model the concentration of caffeine eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
caffeine
elimination
pharmacokinetics
drug
Modeling Scenario
259
views
185
downloads
0
comments
1-130-AspirinAbsorption-ModelingScenario
We model the amount of aspirin absorbed by the human body at a constant rate. This is a ``zero-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
pharmacokinetics
drug
aspirin
Modeling Scenario
336
views
537
downloads
0
comments
1-132-DigoxinElimination-ModelingScenario
We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
nullclines
pharmacokinetics
digoxin
drug elimination
two compartment
Modeling Scenario
401
views
275
downloads
0
comments
1-138-InnerEarDrugDelivery-ModelingScenario
Students examine local drug delivery to the cochlea. The delivery system is modeled as a liquid mixing problem. Students formulate the differential equation, and solve the equation using separation of variables or integrating factor.
concentration
drug delivery
inner ear
cochlea
hearing loss
Modeling Scenario
650
views
394
downloads
0
comments
5-011-ModelingIbuprofren-ModelingScenario
We consider modeling of data from a clinical experiment administered as oral doses of 400 mg ibuprofen, an analgesic pain reliever. Concentrations of ibuprofen in the serum/plasma of the subjects were recorded after the initial ingestion of the...
data
AIC
Akaike Information Criterion
absorption
sum of square errors
compartment model
ibuprofen
delay
Technique Narrative
488
views
163
downloads
0
comments
5-012-LinearSystemConjecture-TechniqueNarrative
Students go from the solution for y'(t) = k*y(t) to a natural extension to the solution conjecture of a system of two constant coefficient, homogeneous, linear differential equations introducing eigenvalues and eigenvectors through student...
discovery learning
conjecture
solution
substitution
Modeling Scenario
208
views
239
downloads
0
comments
5-020-ParacetamolAbsorption-ModelingScenario
We offer drug absorption data on paracetamol, an analgesic pain reliever, for two different sets of patients, vegetarian and non-vegetarian. Students build a two compartment model for plasma and non-plasma (tissue) compartments of human patients.
paracetamol
analgesic
vegetarian
non-vegetarian
Modeling Scenario
335
views
136
downloads
0
comments
1-115-ModelingWithFirstOrderODEs-ModelingScenario
Several models using first order differential equations are offered with some questions on formulating a differential equations model with solutions provided.
bacteria
falling object
Newton's Law of Cooling
drug
cooling
drag
Modeling Scenario
245
views
141
downloads
0
comments
3-027-BobbingDropping-ModelingScenario
We present two exercises in which we ask students to model (1) falling object experiencing terminal velocity and (2) bobbing block of wood in liquid. We model the motion using Newton's Second Law of Motion and Archimedes' Principle.
drug resistance
directed
buoyancy
free fall
static equilibrium
displacement
Modeling Scenario
282
views
188
downloads
0
comments
5-023-FakingGause-ModelingScenario
We use a fake or toy data set to permit discovery of the parameters in a two population protozoan model used to study paramecium and yeast competition in the 1930's studies of G. F. Gause in the Soviet Union.
competition
logistic
yeast
Gause
paramecium
poplulation
Modeling Scenario
306
views
232
downloads
0
comments
1-027-StochasticProcesses-ModelingScenario
We build the infinite set of first order differential equations for modeling a stochastic process, the so-called birth and death equations. We will only need to use integrating factor solution strategy or DSolve in Mathematica for success.
Variance
Mean
stochastic
random
operations research
industrial engineering
Poisson process
traffic
Technique Narrative
485
views
496
downloads
0
comments
1-005-NavigatingNumericalMethods-TechniqueNarrative
This technique narrative is a discovery-based approach to learning the basics of numerical methods for first order differential equations, by following the graphical and analytical perspectives of the forward Euler method and second order Taylor...
Euler's method
Taylor's Method
search and rescue
Coaast Guard
lost at sea
longitude
latitude
limit definition
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