Skip to Main Content
Powered by QUBES

Resources

Text Search:
Applied Filters
    Modeling Scenario
    354

    views

    206

    downloads

    0

    comments

    5-022-ColdPill-ModelingScenario
    A model for the flow of a cold pill drug through the gastrointestinal compartment to the bloodstream compartment of a human subject is proposed. Students solve the system of differential equation model, use known parameter values, and plot solutions.
    ratesmedicinedrug discoverycompartmentcold pillgastrointestinalbloodstream
    Modeling Scenario
    308

    views

    239

    downloads

    0

    comments

    7-010-MultipleDoses-ModelingScenario
    Two multiple dose drug administration regimens are offered. A drug is to maintain a certain level (above a set minimum and below a set maximum) in the blood stream and one regimen involves bolus injections and another involves steady drip flow...
    drug discoverystep functiondoseDiracdrug administrationinverse Laplace Transformintraveneousbolussteady drip
    Modeling Scenario
    378

    views

    199

    downloads

    0

    comments

    1-016-DogDrugs-ModelingScenario
    We offer a problem to determine the necessary drug administration in order to keep a dog sedated with specific information on half-life for an exponentially decaying presence of the drug in the body.
    wild_dogsdrug discoveryhalf-lifepentobarbital sodiumanesthesia
    Modeling Scenario
    309

    views

    228

    downloads

    0

    comments

    1-085-DrugBolus-ModelingScenario
    Given data on the concentration of a drug in the plasma of a human in mg/L at certain time intervals in hours can we determine the rate at which the drug leaves the plasma as well as the initial amount administered in a intravenous bolus of the drug?
    concentrationsum of square errorsbolusdrugrate constantadminister
    Modeling Scenario
    230

    views

    114

    downloads

    0

    comments

    1-080-DrugAdministration-ModelingScenario
    A simple drug administration situation is modeled with only two observations.
    decaybloodstreamdrugrate constantadminister
    Modeling Scenario
    333

    views

    123

    downloads

    0

    comments

    1-131-CaffeineElimination-ModelingScenario
    We model the concentration of caffeine eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
    caffeineeliminationpharmacokineticsdrug
    Modeling Scenario
    336

    views

    537

    downloads

    0

    comments

    1-132-DigoxinElimination-ModelingScenario
    We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.
    nullclinespharmacokineticsdigoxindrug eliminationtwo compartment
    Modeling Scenario
    401

    views

    275

    downloads

    0

    comments

    1-138-InnerEarDrugDelivery-ModelingScenario
    Students examine local drug delivery to the cochlea. The delivery system is modeled as a liquid mixing problem. Students formulate the differential equation, and solve the equation using separation of variables or integrating factor.
    concentrationdrug deliveryinner earcochleahearing loss
    Modeling Scenario
    650

    views

    394

    downloads

    0

    comments

    5-011-ModelingIbuprofren-ModelingScenario
    We consider modeling of data from a clinical experiment administered as oral doses of 400 mg ibuprofen, an analgesic pain reliever. Concentrations of ibuprofen in the serum/plasma of the subjects were recorded after the initial ingestion of the...
    dataAICAkaike Information Criterionabsorptionsum of square errorscompartment modelibuprofendelay
    Technique Narrative
    488

    views

    163

    downloads

    0

    comments

    5-012-LinearSystemConjecture-TechniqueNarrative
    Students go from the solution for y'(t) = k*y(t) to a natural extension to the solution conjecture of a system of two constant coefficient, homogeneous, linear differential equations introducing eigenvalues and eigenvectors through student...
    discovery learningconjecturesolutionsubstitution
    Modeling Scenario
    208

    views

    239

    downloads

    0

    comments

    5-020-ParacetamolAbsorption-ModelingScenario
    We offer drug absorption data on paracetamol, an analgesic pain reliever, for two different sets of patients, vegetarian and non-vegetarian. Students build a two compartment model for plasma and non-plasma (tissue) compartments of human patients.
    paracetamolanalgesicvegetariannon-vegetarian
    Technique Narrative
    460

    views

    211

    downloads

    0

    comments

    5-030-LinNonHomoSystemSol-TechniqueNarrative
    We offer strategies for solving linear systems of nonhomogeneous differential equations using a conjectured solution strategy for a system of constant coefficient, linear, n
    strategiesdiscovery learningeigenvectorseigenvalue
    Modeling Scenario
    461

    views

    129

    downloads

    0

    comments

    6-017-OncolyticViruses-ModelingScenario
    Students explore oncolytic virotherapy using systems of differential equations and numerical simulations.
    cancercancer-immune dynamicsimmune suppressor drugoncolytic virusvirotherapy
    Modeling Scenario
    335

    views

    136

    downloads

    0

    comments

    1-115-ModelingWithFirstOrderODEs-ModelingScenario
    Several models using first order differential equations are offered with some questions on formulating a differential equations model with solutions provided.
    bacteriafalling objectNewton's Law of Coolingdrugcoolingdrag
    Modeling Scenario
    245

    views

    141

    downloads

    0

    comments

    3-027-BobbingDropping-ModelingScenario
    We present two exercises in which we ask students to model (1) falling object experiencing terminal velocity and (2) bobbing block of wood in liquid. We model the motion using Newton's Second Law of Motion and Archimedes' Principle.
    drug resistancedirectedbuoyancyfree fallstatic equilibriumdisplacement
    Modeling Scenario
    306

    views

    232

    downloads

    0

    comments

    1-027-StochasticProcesses-ModelingScenario
    We build the infinite set of first order differential equations for modeling a stochastic process, the so-called birth and death equations. We will only need to use integrating factor solution strategy or DSolve in Mathematica for success.
    VarianceMeanstochasticrandomoperations researchindustrial engineeringPoisson processtraffic
    Technique Narrative
    485

    views

    496

    downloads

    0

    comments

    1-005-NavigatingNumericalMethods-TechniqueNarrative
    This technique narrative is a discovery-based approach to learning the basics of numerical methods for first order differential equations, by following the graphical and analytical perspectives of the forward Euler method and second order Taylor...
    Euler's methodTaylor's Methodsearch and rescueCoaast Guardlost at sealongitudelatitudelimit definition