Abstract

Citation

Researchers should cite this work as follows:

• Winkel, B. (2022). 5-020-ParacetamolAbsorption-ModelingScenario. SIMIODE, QUBES Educational Resources. doi:10.25334/S905-RF31

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Article Context

Description

Paracetamol is an analgesic (pain reliever) and a study seeks to determine the effects of diet on the absorption (meaning the amount of the drug which gets into the plasma portion of the body from the non-plasma portion of the body through which it is ingested) of paracetamol from the non-plasma part of the body after it is ingested into the non-plasma part of the body through swallowing a solution of `Coca Cola' in which the paracetamol was dissolved in the liquid.

Two kinds of subjects were involved (a) vegetarian and (b) non-vegetarian.

We build a two compartment model for plasma and non-plasma (tissue) compartments of human patients and determine parameters in a complete model analysis.

We will use data from experiments on 10 patients reported and attempt to model the amount of paracetamol in the non-plasma portion of the body, principally in the tissue where the analgesic effect takes place.