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5-012-LipoproteinModeling-ModelingScenario

Author(s): Brian Winkel

SIMIODE - Systemic Initiative for Modeling Investigations and Opportunities with Differential Equations

Keywords: wildlife low-density-lipoprotein tracer compartment model cholesterol blood plasma body tissue

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Abstract

Resource Image Data from a study on the amounts of low-density-lipoprotein (LDL), form of cholesterol, in blood plasma is presented. Students build, validate, and use a compartment model of the kinetic exchange of the LDL between body tissue and blood plasma.

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Article Context

Resource Type
Differential Equation Type
Technique
Qualitative Analysis
Application Area
Course
Course Level
Lesson Length
Technology
Approach
Skills
Key Scientific Process Skills
Assessment Type
Pedagogical Approaches
Vision and Change Core Competencies - Ability
Principles of How People Learn
Bloom's Cognitive Level

Description

The background for this modeling scenario appears in a section entitled The Basic Estimation Problem in which the author describes a number of parameter estimation techniques using the data which is based on baboon low-density-lipoprotein (LDL) data taken over a 10-day period in laboratory animal studies. The data is in time, days, with amount of a tracer compound in Compartment 1 - Blood Plasma while the experiment consists of a bolus injection of a unit amount of tracer into Compartment 1 - Blood Plasma at time t = 0, and then subsequent sampling of Compartment 1 at times t in days. Compartment 2 is the extravascular or non-blood plasma space of the body. The single model with radioactive labeled LDL) is a used.

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Authors

Author(s): Brian Winkel

SIMIODE - Systemic Initiative for Modeling Investigations and Opportunities with Differential Equations

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