Abstract

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Researchers should cite this work as follows:

• Han, J. (2023). 2006-Han-EtAl-Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology. SIMIODE, QUBES Educational Resources. doi:10.25334/QE6V-C311

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Jae-Joon Han, Martin H. Plawecki, Peter C. Doerschuk, Vijay A. Ramchandani, and Sean O’Connor. 2006. Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology.   Proceedings of the 28th IEEE EMBS Annual International Conference New York City, USA, Aug 30-Sept 3.

See https://www.researchgate.net/publication/5899537_Ordinary_differential_equation_models_for_ethanol_pharmacokinetic_based_on_anatomy_and_physiology . Accessed 27 March 2023.

Abstract: Physiologically-based pharmacokinetic (PBPK) models have been used to describe the distribution and elimination characteristics of intravenous ethanol administration. Further, these models have been used to estimate the ethanol infusion profile required to prescribe a specific breath ethanol concentration time course in a specific human being, providing a platform upon which other pharmacokinetic and pharmacodynamic investigations are based. In these PBPK models, the equivalence of two different peripheral tissue models are shown and issues concerning the mass flow into the liver in comparison with ethanol metabolism in the liver are explained.

Keywords: pharmacokinetics, pharmacodynamic, liver, ethanol infusion, intraveneous