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Downloads
Views
Date
Relevance
Potential Scenario
118
views
37
downloads
0
comments
2008-Ribbing-EtAl-Mathematical models of diabetes progression
Writing a good model for diabetes progression is difficult because the long time span of the disease makes experimental verification of modeling hypotheses extremely awkward. underlying the
physiology
clinical trials
diabetes
diabetes progression
Potential Scenario
103
views
30
downloads
0
comments
2008-Huangi-Lu-Modeling long-term longitudinal HIV dynamics with applications to an AIDS clinical studyÂ
To better understand the factors responsible for the virological failure, this paper develops the mechanism-based nonlinear differential equation models for characterizing long-term viral dynamics with ARV therapy.
longitudinal data
AIDS
antiretroviral drug therapy
Bayesian nonlinear mixed-effects
time-varying drug efficacy
HIV dynamics
Potential Scenario
158
views
74
downloads
0
comments
2014-Enderling-Chaplain-Mathematical Modeling of Tumor Growth and Treatment
Herein we describe fundamentals of mathematical modeling of tumor growth and tumor-host interactions, and summarize some of the seminal and most prominent approaches.
cancer
tumor modeling
angiogenesis
tumor growth
patient care
Potential Scenario
118
views
38
downloads
0
comments
1999-Peter_Deuflhard-Differential Equations in Technology and Medicine
It deals with a variety of challenging real life problems selected from clinical cancer therapy, communication technology, polymer production, and pharmaceutical drug design.
cancer
design
tumor
drug
polymer
therapy
Potential Scenario
107
views
28
downloads
0
comments
2007-Zenker-Rubin-Clermont-From inverse problems in mathematical physiology to quantitative differential diagnoses
The improved capacity to acquire quantitative data in a clinical setting has generally failed to improve outcomes in acutely ill patients, suggesting a need for advances in computer-supported data interpretation and decision making.
physiology
inverse problem
Potential Scenario
158
views
44
downloads
0
comments
1967-JG-Wagner-Computers in pharmacokinetics
This is a seminal paper in pharmacokinetics in which the author introduces historic notions and approaches. As can be seen from the abstract there is a variety of material here.
kinetics
computers
pharmacokinetics
Potential Scenario
129
views
41
downloads
0
comments
1969-Carl_Metzler-A mathematical model for the pharmacokinetics of LSD effect
Contains data on performance scores vs. plasma levels of LSD in human tissues.
LSD
testing
pharmacokinetics
performance
plasma level
Potential Scenario
100
views
40
downloads
0
comments
2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
absorption
compartment
bloodstream
plasma
pharmacokinetics
drug
pharmacodynamics
Potential Scenario
98
views
55
downloads
0
comments
2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.
absorption
compartment
bloodstream
plasma
pharmacokinetics
pharmacodynamics
therapeutic concentration range
drug disposition
drug response
Potential Scenario
148
views
53
downloads
0
comments
2015-Valerie_Billard-Pharmacokinetic-pharmacodynamic relationship of anesthetic drugs - from modeling to clinical use
The purpose of this short review is to describe the basis of pharmacokinetics and modeling, the concentration-effects relationship, and drug interactions modeling to offer to anesthesiologists and non-anesthesiologists an overview of the rules to...
anesthesia
pharmacokinetics
pharmacodynamic
anesthetic
Potential Scenario
93
views
38
downloads
0
comments
2010-Shianga-EtAl-Computational model of the human glucose-insulin regulatory system
A computational model of insulin secretion and glucose metabolism for assisting the diagnosis of diabetes mellitus in clinical research is introduced. The
glucose tolerance test
sum of squared residuals
multiple shooting method
cost function
Potential Scenario
138
views
49
downloads
0
comments
2003-Richard-Carson-Tracer kinetic modeling in PET
The use of radiopharmaceuticals and the imaging of their biodistribution and kinetics with modern instrumentation are key components to successful developments in PET.
Metabolism
tomography
radiopharmaceuticals
positron emission
Modeling Scenario
201
views
116
downloads
0
comments
3-063-FallingBuildingIce-ModelingScenario
We model the fall of a piece of ice which is falling from a high building in New York City.
resistance
falling
gravity
ice
terminal velocity
skyscrapers
Potential Scenario
92
views
37
downloads
0
comments
2009-Marten-EtAl-Derivation and analysis of an ordinary differential equation for epilepsy dynamics
In this paper we describe how an ordinary differential equation model of corticothalamic interactions may be obtained from a more general system of delay differential equations.
delay
epilepsy dynamics
epilepsy
bistability
seizure activity
Modeling Scenario
524
views
297
downloads
0
comments
5-011-ModelingIbuprofren-ModelingScenario
We consider modeling of data from a clinical experiment administered as oral doses of 400 mg ibuprofen, an analgesic pain reliever. Concentrations of ibuprofen in the serum/plasma of the subjects were recorded after the initial ingestion of the...
data
AIC
Akaike Information Criterion
absorption
sum of square errors
compartment model
ibuprofen
delay
Potential Scenario
119
views
38
downloads
0
comments
1971-Boyes-Scott-Jebson-Godman-Julian-Lidocaine in Man
Plasma levels of lidocaine were measured in 5 normal male volunteers following both intravenous and oral administration of the drug.
p
Pharmacology
pharmacokinetics
lidocaine
Potential Scenario
221
views
53
downloads
0
comments
1968-Wagner-Aghajanian-Bing-Correlation of performance test scores with tissue concentration of lysergic acid diethylamide
This paper offers a two compartment model of lysergic acid diethylamide (LSD) in volunteer students and through parameter estimation models the amount of LSD in the tissue after its initial administration through the plasma.
LSD
correlation coefficient
compartment model
lysergic acid diethylamide
performance
test score
tissue concentration
Potential Scenario
270
views
41
downloads
0
comments
1976-JG-Wagner-Computers in pharmacokinetics
This is a seminal paper in pharmacokinetics in which the author introduces historic notions and approaches. As can be seen from the abstract there is a variety of material here.
kinetics
computer
parameters
Pharmacology
drugs
pharmacokinetics
Potential Scenario
100
views
42
downloads
0
comments
2019-Radulescu-Lundgren-A_pharmacokinetic_model_of_lead_absorption_and_calcium_competitive_dynamics
We build and analyze a compartmental model of lead pharmacokinetics, focused specifically on addressing neurotoxicity.
QUBES Leadership Team
parameters
absorption
bifurcation
pharmacokinetics
calcium
cognitive decline
Article or Presentation
121
views
44
downloads
0
comments
1994-T_Gruszka-A_Balloon_Experiment_in_the_Classroom
The experiment consists of dropping a balloon from two different heights and recording the time it takes to hit the floor. The following experiment involves a balloon, a stopwatch, and a measurement device such as a meter stick.
differential equations
resistance
gravity
free fall
acceleration
balloon
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