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Views
Date
Relevance
Potential Scenario
114
views
38
downloads
0
comments
1999-Peter_Deuflhard-Differential Equations in Technology and Medicine
It deals with a variety of challenging real life problems selected from clinical cancer therapy, communication technology, polymer production, and pharmaceutical drug design.
cancer
design
tumor
drug
polymer
therapy
Modeling Scenario
340
views
229
downloads
0
comments
1-150-CancerTherapy-ModelingScenario
This activity builds upon elementary models on population growth. In particular, we compare two different treatment models of cancer therapy where in one, surgery happens before therapy and in the other, surgery happens after therapy.
population dynamics
phage therapy
exponential growth
cancer
water treatment
decay
surgery
Potential Scenario
102
views
30
downloads
0
comments
2008-Huangi-Lu-Modeling long-term longitudinal HIV dynamics with applications to an AIDS clinical studyÂ
To better understand the factors responsible for the virological failure, this paper develops the mechanism-based nonlinear differential equation models for characterizing long-term viral dynamics with ARV therapy.
longitudinal data
AIDS
antiretroviral drug therapy
Bayesian nonlinear mixed-effects
time-varying drug efficacy
HIV dynamics
Article or Presentation
87
views
27
downloads
0
comments
2002-Patrick_Nelson-Alan_Perelson-Mathematical_analysis_of_delay_differential _equation_models_of_HIV-1_infection
Models of HIV-1 infection that include intracellular delays are more accurate representations of the biology and change the estimated values of kinetic parameters when compared to models without delays.
delay
HIV-1
T cells
combination antiviral therapy
Potential Scenario
143
views
43
downloads
0
comments
2002-Nelson-Perelson-Mathematical analysis of delay differential equations models of HIV-1 infection
We develop and analyze a set of models that include intracellular delays, combination antiretroviral therapy, and the dynamics of both infected and uninfected T cells.
infection
HIV
T cells
Potential Scenario
92
views
67
downloads
0
comments
2014-Wang-EtAl-Estimating Mixed-Effects Differential Equation Models
When multiple replicates of measurements are available for the dynamic process, it is of great interest to estimate mixed-effects in the ODE model for the process. We propose a semiparametric method to estimate mixed-effects ODE models.
pharmacokinetics
dynamic models
smoothing
spline
mixed-effects models
HiV combination therapy
Potential Scenario
117
views
35
downloads
0
comments
2009-Su-EtAl-Fitting Compartmental Models to Multiple Dose Pharmacokinetic Data using SAS
In the case of a multiple dose study where subjects experience different dosing times, a superposition principle can be used to recursively account for each additional dose.
SAS
superposition
pharmacokinetics
compartmental models
multiple dose
Potential Scenario
73
views
34
downloads
0
comments
2012-Shargel-Yu-AccessPharmacy-Applied Biopharmaceutics and Pharmacokinetics
Step by step formation of drug absorption models is shown with many good graphics of system and plots. Solutions are offered but no solution methods are shown.
Michaelis-Menten
Enzyme
substrate
compartment
pharmacokinetics
rate constant
urinary data
absorption rate
Potential Scenario
99
views
27
downloads
0
comments
2007-Zenker-Rubin-Clermont-From inverse problems in mathematical physiology to quantitative differential diagnoses
The improved capacity to acquire quantitative data in a clinical setting has generally failed to improve outcomes in acutely ill patients, suggesting a need for advances in computer-supported data interpretation and decision making.
physiology
inverse problem
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