Abstract

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Researchers should cite this work as follows:

• Wilkie, K. (2023). 2016-Wilkie-EtAl-Using ODEs to Explore Cancer-Immune Dynamics and Tumor Dormancy. SIMIODE, QUBES Educational Resources. doi:10.25334/5RMA-0T48

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Wilkie, Kathleen P., Philip Hahnfeldt, and Lynn Hlatky. 2016. Using Ordinary Differential Equations to Explore Cancer-Immune Dynamics and Tumor Dormancy. Preprint. 3 pp.

See https://www.biorxiv.org/content/10.1101/049874v1. Accessed 28 March 2023.

Abstract: Cancer is not solely a disease of the genome, but is a systemic disease that affects the host on many functional levels, including, and perhaps most notably, the function of the immune response, resulting in both tumor-promoting inflammation and tumor-inhibiting cytotoxic action. The dichotomous actions of the immune response induce significant variations in tumor growth dynamics that mathematical modeling can help to understand. Here we present a general method using ordinary differential equations (ODEs) to model and analyze cancer-immune interactions, and in particular, immune-induced tumor dormancy.