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Using Bioinformatics and Molecular Visualization to Develop Student Hypotheses in a Malate Dehydrogenase Oriented CURE
Callahan KP, Mans T, Zhang J, Bell E, Bell J. 2021. Using bioinformatics and molecular visualization to develop student hypotheses in a malate dehydrogenase oriented CURE. CourseSource. 10.24918/cs.2021.43
Abstract
Developing student creativity and ability to develop a testable hypothesis represents a significant challenge in most laboratory courses. This lesson demonstrates how students use facets of molecular evolution and bioinformatics approaches involving protein sequence alignments (Clustal Omega, Uniprot) and 3D structure visualization (Pymol, JMol, Chimera), along with an analysis of pertinent background literature, to construct a novel hypothesis and develop a research proposal to explore their hypothesis. ...
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Published papers
This is a collection of papers that describe the CURE programs and outcomes.
Sam S Donovan
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