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    Why are Cells Small? Surface Area to Volume Ratio
    This module explores surface area to volume ratios in a cube and sphere in relation to cell size.

    Keywords: introductory biologygraphingRatiosOpenStaxqbccmanipulate equationsCellular and Molecular BiologyUse elementary functionsCreate graphsInterpret graphsRates and ProportionsSolving Equations and Inequalitiesinterpret tables

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    Uninhibited Growth of Cells
    In this activity, students will explore the concept of binary fission, generation time, and bacterial growth curves, with an emphasis on the log phase. Students will use semi-log graphs and linear...

    Keywords: graphingexponential growthMicrobiology Educationmicrobiologybacteriagrowth rateUndergraduate STEM educationCommunity College Educationqbccmanipulate equationsCellular and Molecular BiologyCreate graphsInterpret graphsbinary fissionsemi-log graphlinear graphgrowth curvecreating graphsExponential and Logarithmic Functions

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    Graphing bacterial growth rates: semi-log graphs v linear graphs
    In this activity, students will explore the concept of binary fission, generation time, and bacterial growth curves, with an emphasis on the log phase. Students will use semi-log graphs and linear...

    Keywords: graphingexponential growthMicrobiology Educationmicrobiologybacteriagrowth rateUndergraduate STEM educationCommunity College Educationqbccmanipulate equationsCellular and Molecular BiologyCreate graphsInterpret graphsbinary fissionsemi-log graphlinear graphgrowth curvecreating graphsExponential and Logarithmic Functions

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    Sizes, Scales and Specialization: Using Relative Proportions and Scientific Notation to Highlight the Diversity of Cell Types
    This module explores how cell size and shape varies across cell types in the human body by having students calculate relative proportions of numbers in scientific notation.

    Keywords: ExponentsRatiosCellsqbccmanipulate equationsCellular and Molecular BiologyVisual Accommodationsconverting unitschanging scales

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    Learn Biological Sciences and Mathematics through cellular respiration, photosynthesis and primary productivity.
    Photosynthesis is a process by which plants synthesize glucose and oxygen in presence of sunlight through light dependent reactions by utilization of sunlight, water to synthesize oxygen, ATP and...

    Keywords: mathematicssimulationThe Analysis of Biological DataMetabolic Pathwaysprocess of sciencephotosynthesisqbccBiological ScienceshypothesisCellular Respirationprimary productivity

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    CRISPR Gene Editing: Designing the gRNA and Donor Template
    In this adaptation, students learn how CRISPR/Cas9 is used in bacterial immunity and gene editing. Students create both a gRNA target and a donor template to edit a gene. Mutations can be from the...

    Keywords: geneticseducationcell biologymolecular biologymutationStem cellsstructure-functionmolecular visualization and analysis3D protein structure /function analysisCRISPR/Cas9crisprDNA mutationPiwiPDBMolecular Case StudyPiwi Matters

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    Effect of the Intestinal Protein Snakeskin on the Lifespan of Fruit Flies: A Kaplan-Meier Survival Analysissource Draft (1)
    In this activity, students perform the Kaplan-Meier survival analysis on raw data obtained from an experiment that explores the effect of overexpressing the Snakeskin (Ssk) protein on the lifespan...

    Keywords: graphingBiochemistryhypothesis testingcalculus and biologyapproximating areas under curvesqbccCellular and Molecular BiologyCreate graphsInterpret graphsSolving Equations and Inequalitiesinterpret tablesConcepts in Statisticsusing statisticschi-square analysissurvival analysis

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    COVID-19: Molecular Basis of Infection-ADAPTATION
    This case was written in Spring 2020 during the COVID-19 pandemic. It focuses on understanding the structure and interaction of the SARS-Cov-2 viral spike protein that facilitates infection in...

    Keywords: infectionvaccinemolecular visualization and analysisCOVID19PDBSARS-CoVMolecular Case Study

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    Understanding COVID-19 Biology to Design a Vaccine - Ethics supplement
    The adaptation to Understanding COVID-19 Biology to Design a Vaccine entails two ethics supplements. The first supplement addresses the use of off-label drugs in the pandemic (or other situation)....

    Keywords: bioethicsBLASTprotein structure modelingmolecular visualization and analysisethicsCOVID19PDB

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    Fitting Exponential and Logistic Growth Models to Bacterial Cell Count Data
    In this activity, students will model a noisy set of bacterial cell count data using both exponential and logistic growth models. For each model the students will plot the data (or a linear...

    Keywords: modelingdata analysislinear regressiongraphingExponentsoptimizationcalculusInterpreting GraphsFunctionsqbccCellular and Molecular BiologyChoosing modelsUnderstanding ratesConcepts in Statisticsmeasurementsmanipulating equationscreating graphsExponential and Logarithmic Functionsinterpreting tables

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    When did I lose my legs? A limbless lizard tale
    Using oVERT project models students examine examples of extant traditional lizards, snakes and limbless lizards and create phylogenies based on trait and genetic data.

    Keywords: phylogeneticsevolutionary biologyHerpetologynatural history collections3D models#NGSSdigitized natural history collectionsoVertConvergent Evolution

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    Learn Biological Sciences and Chemistry through cellular transport and concentration ( online and hands-on)
    Osmosis is a process by which by which solvent move from a region of lower solute concentration to region of higher solute concentration through a semi-permeable membrane. Cells utilize the process...

    Keywords: statisticsdata analysisbiologycell biologyconcentrationskillscellchemistryOsmosisSpectrophotometersolutionsolutesolvent

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    Introductory Video and worksheets on Module 1 and 2 on "Sequence Similarity: An inquiry based and under the hood..."
    The video walks the students to complete Module 1 and 2 on Sequence Similarly and Alignment adapted from Tapprich (2019) and Hudson Alpha that teaches these modules within the context of the...

    Keywords: bioinformaticssequencingFASTANCBINIBLSEalgorithmsBLASTmultiple sequence alignmentsequence similarityBLOSUM scoring matrixCourseSource

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    Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes
    This lesson is a five-week series of laboratory activities designed to help students transition from applying lower order thinking skills to the central dogma to applying higher-order thinking skills.

    Keywords: bioinformaticsNIBLSEProtein StructureDNAmolecular modelinggenotypephenotypeCourseSourcecomputational modelingcentral dogmaplant leaf structure

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    Using Regression Models to Examine the Effect of Carbon Dioxide on Fluid pH
    In this activity students will use statistics and regression models to explore the effects of carbon dioxide on blood pH by measuring pH changes that occur over time as carbon dioxide reacts with...

    Keywords: BiochemistryphysiologyAnatomyGeneral BiologyChoosing modelsCreate graphsInterpret graphsConcepts in Statisticscreate modelsmake predictions

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    Bioinformatics: Investigating Sequence Similarity - A Plant Biology Approach
    This laboratory module is a modification of the original published on CourseSource with a focus on plant biology. In the final activity, students conduct a BLAST to compare histone protein...

    Keywords: phylogeneticsbioinformaticssequencingFASTANCBIplant biologyNIBLSEalgorithmsincubatorsPlant and Fungal EvolutionBLASTmultiple sequence alignmentsequence similarityBLOSUM scoring matrixneighbor-joining distance matrixCourseSourcephylogram

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    Analyzing Data on Behavioral and Immunological Effects of Inflammation in Mice
    In this activity, students will learn about behavioral and immunological responses to a bacterial infection. The activity emphasized the host’s responses rather than bacterial manipulation of the...

    Keywords: Vision and Changedata analysisImmunologybehaviorphysiologyinflammationinterdisciplinary educationAntigenmouseImmunoReachSicknessleukocyteneutrophilLipopolysaccharideacute phase response

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    Sequence Similarity: An inquiry based and "under the hood" approach for incorporating molecular sequence alignment in introductory undergraduate biology courses
    This laboratory module, published on CourseSource, leads introductory biology students in the exploration of a basic set of bioinformatics concepts and tools.

    Keywords: phylogeneticsbioinformaticssequencingFASTANCBINIBLSEalgorithmsincubatorsBLASTmultiple sequence alignmentsequence similarityBLOSUM scoring matrixneighbor-joining distance matrixCourseSourcephylogramZika virus

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    Learn biotechnology, biophysics and business through scientific thinking and innovation
    Scientific, leadership and innovation skills are also an integral framework of the curriculum. All of them together or individually are important for enhancement of knowledge, critical thinking,...

    Keywords: educationbusinessBiotechnologybiophysicsleadershiprecombinant DNAgroup workcloninginnovationscientific thinkingplasmid

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    Molecular Basis of Sickle Cell Disease
    This multi part case on hemoglobin structure as it relates to oxygen binding and sickle cell disease focuses on utilizing bioinformatics and molecular visualization tools to learn about the sickle...

    Keywords: Hemoglobinmolecular visualization and analysisintroductory bioinformaticssickle cell diseasePDBMolecular Case Studyoxygen bindingmyoglobinmolecular literacy3D protein structuresstructural representations

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