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Teaching the Central Dogma Using a Case Study of Genetic Variation in Cystic Fibrosis

The central dogma of biology is a foundational concept that is traditionally included in genetics curricula at all academic levels. Despite its ubiquitous presence throughout genetics education,...

Keywords: transcriptioncentral dogmatranslationsequence analysisDNA replicationgenetic variants

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An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure

Gene structure, transcription, translation, and alternative splicing are challenging concepts for many undergraduates studying biology. These topics are typically covered in a traditional lecture...

Keywords: bioinformaticsGenome BrowsergenomicsRNAseqsplicingComputer ModelGene Structure

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Predicting and classifying effects of insertion and deletion mutations on protein coding regions

Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of...

Keywords: mutationcentral dogmatranslationframeshift

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Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes

Students require a deep understanding of the central dogma before they can understand complex topics such as evolution and biochemical disorders. However, getting undergraduate biology students to...

Keywords: Protein Structurecomputational modelingcentral dogmaplant leaf structurePhenotype/Genotype

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Application of a Bacterial Experimental Evolution System to Visualize and Teach Evolution in Action: A Course-Based Undergraduate Research Experience

Concepts of evolution are typically taught through examples of extremely long timescales, which do not always resonate broadly. Here, we describe a course-based undergraduate research experience...

Keywords: EvolutionmutationcompetitionNatural Selectionregulationstructure and functionreproductive fitnessgenotype to phenotypehomologs

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Bringing Pasteur Back to Life: Studying the Biochemistry of Yeast Fermentation Through Discussion Groups and an At-Home Lab

This hands-on, student-centered biochemistry lesson introduces beginner biochemistry students to the techniques of effectively reading and discussing primary literature, identifying fundamental...

Keywords: primary literatureexperimentationyeastMetabolismFermentationRespirationequilibrium

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How to Design a Classroom Activity that Integrates 3D Print Models with Active Learning

Student exploration of relevant physical models can deepen knowledge of course material. In this guide we describe a method by which instructors can integrate 3D printing technology with an...

Keywords: active learning3D print modelsclassroom jigsaw

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A simple way for students to visualize cellular respiration: adapting the board game MousetrapTM to model complexity

Lecture-based introductory biology courses are typically content-heavy as instructors strive to provide students with foundational knowledge in a broad range of topics. One topic...

Keywords: ATPGlycolysisCellular RespirationElectron Transport ChainKrebs Cycle

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Moths and Frogs and E. coli, Oh My!: Agent-based Modeling of Evolutionary Systems

In evolution classrooms, introducing and reinforcing the idea of genetic drift and random selection can be challenging, as can be reinforcing appropriate mental models of evolution. Agent-based...

Keywords: modelingEvolutionecologyagent-based modelingGenetic Driftenvironmental scienceNatural Selectioncompetitive coevolutionsimulation modelingevolutionary reasoning

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From Cre/LoxP to Fate Maps: Inclusive and Equitable Approaches for Engaging Developmental Biology Students in Experimental Design

Engaging first generation underrepresented minority students in the process of inquiry in developmental biology is important to increase diversity in future graduate STEM education. One important...

Keywords: experimental designC. elegansCre/LoxPFate mapheart developmentheart regenerationmousereporter constructzebrafish

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Investigating Gene Expression and Cell Specialization in Axolotl Embryos

The process of cell specialization is critical to the formation and function of tissues in animals and plants. Although gene expression, including the regulation of transcription, is taught in most...

Keywords: developmenttranscriptiongene expressionmodel organismembryo

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DNA Detective: Genotype to Phenotype. A Bioinformatics Workshop for Middle School to College.

Advances in high-throughput techniques have resulted in a rising demand for scientists with basic bioinformatics skills as well as workshops and curricula that teach students bioinformatics...

Keywords: geneticsbioinformaticsDNAgenotypephenotypegenegene annotation

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Go Extinct! An Award-Winning Evolution Game That Teaches Tree-Thinking as Students Pursue the Winning Strategy

Evolutionary trees communicate both the diversity and unity of life, a central and important scientific concept, as highlighted by the Vision and Change undergraduate biology education movement....

Keywords: phylogeneticsnatural historyBiodiversitycladogramCommon ancestorEvolutionary treeLand vertebratesMonophyletic cladeTetrapods

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A Laboratory Module That Explores RNA Interference and Codon Optimization Through Fluorescence Microscopy Using Caenorhabditis elegans

Scientific research experiences are beneficial to students allowing them to gain laboratory and problem-solving skills, as well as foundational research skills in a team-based setting. We designed...

Keywords: microscopyC. elegansquantitative analysisinquiry-based learninggene expressionRNA interferenceCodon UsageLaboratory Module

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Teaching Advanced Concepts in Regulation of the Lac Operon With Modeling and Simulation

Success in biochemistry and other life science courses requires that students understand important biological concepts. One of these concepts is how gene regulation ensures that homeostasis is...

Keywords: gene regulationinducible operonProkaryotic cellPhosphoenolpyruvate transferase system (PTS)

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A CRISPR/Cas Guide RNA Design In Silico Activity

CRISPR biotechnologies inspired by the Clustered Regularly Interspaced Short Palindromic Repeat RNA-guided nuclease adaptive bacterial immune system have revolutionized biology research and become...

Keywords: bioinformaticsgene expressiongenetic basis of diseaseCRISPR/Cas9genetic engineeringin silico

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Investigating Cell Signaling with Gene Expression Datasets

Modern molecular biology is a data- and computationally-intensive field with few instructional resources for introducing undergraduate students to the requisite skills and techniques for analyzing...

Keywords: genomicstranscriptionsignaling

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Teaching the Central Dogma Using a Case Study of Genetic Variation in Cystic Fibrosis

An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure

Predicting and classifying effects of insertion and deletion mutations on protein coding regions

Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes

Application of a Bacterial Experimental Evolution System to Visualize and Teach Evolution in Action: A Course-Based Undergraduate Research Experience

Bringing Pasteur Back to Life: Studying the Biochemistry of Yeast Fermentation Through Discussion Groups and an At-Home Lab

How to Design a Classroom Activity that Integrates 3D Print Models with Active Learning

A simple way for students to visualize cellular respiration: adapting the board game MousetrapTM to model complexity

Moths and Frogs and E. coli, Oh My!: Agent-based Modeling of Evolutionary Systems

From Cre/LoxP to Fate Maps: Inclusive and Equitable Approaches for Engaging Developmental Biology Students in Experimental Design

Investigating Gene Expression and Cell Specialization in Axolotl Embryos

DNA Detective: Genotype to Phenotype. A Bioinformatics Workshop for Middle School to College.

Go Extinct! An Award-Winning Evolution Game That Teaches Tree-Thinking as Students Pursue the Winning Strategy

A Laboratory Module That Explores RNA Interference and Codon Optimization Through Fluorescence Microscopy Using Caenorhabditis elegans

Teaching Advanced Concepts in Regulation of the Lac Operon With Modeling and Simulation

A CRISPR/Cas Guide RNA Design In Silico Activity

Investigating Cell Signaling with Gene Expression Datasets

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