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    Antigen presentation and cytotoxic T lymphocytes (CTLs): elucidating a common roadblock for students
    Active learning resource for pre-Nursing anatomy and physiology lecture explaining antigen presentation to CTLs and how the CTLs recognize and destroy the pathogen using Biointeractive animations...

    Keywords: Resources @ HHMI - BioInteractiveimmune systemAnatomy & PhysiologyCell communication

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    Analyzing Data on Behavioral and Immunological Effects of Inflammation in Mice
    In this activity, students will learn about behavioral and immunological responses to a bacterial infection. The activity emphasized the host’s responses rather than bacterial manipulation of the...

    Keywords: Vision and Changedata analysisImmunologybehaviorphysiologyinflammationinterdisciplinary educationAntigenmouseImmunoReachSicknessleukocyteneutrophilLipopolysaccharideacute phase response

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    Targeting Infected Cells for Immune Defense
    This animation shows how a cell infected by a virus signals cytotoxic T cells to destroy itself.

    Keywords: Resources @ HHMI - BioInteractiveimmune systemAnatomy & PhysiologyCell communication

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    "Vaccines.. Where do they come from? And how do they work? By Dane Samilo
    Dane Samilo, a Science and Technology Policy Fellow at the Department of Defense joined us to talk about an extremely relevant topic for all to understand. That is vaccines. He walked us through...

    Keywords: BiotechnologyVaccines

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    Cell Division and the Presence of a Growth Factor
    This module introduces exponential growth, the Michaelis-Menten, and Lineweaver-Burk equations in the context of understanding how growth factors influence cell division. It is intended for an...

    Keywords: exponential equationshyperbolic equationsCell StructureCell Growthgrowth factor

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    CRISPR Gene Editing: Designing the gRNA and Donor Template
    In this adaptation, students learn how CRISPR/Cas9 is used in bacterial immunity and gene editing. Students create both a gRNA target and a donor template to edit a gene. Mutations can be from the...

    Keywords: geneticseducationcell biologymolecular biologymutationStem cellsstructure-functionmolecular visualization and analysis3D protein structure /function analysisCRISPR/Cas9crisprDNA mutationPiwiPDBMolecular Case StudyPiwi Matters

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    Immunity and Vaccine Action
    From the cellular level on up, being aware of your interactions can help you stay safe. This resource addresses fundamental immunology and infectious disease concepts through a historical...

    Keywords: immunology educationvaccine literacyvaccine hesitancy

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    When tests disagree, how do I know if I have COVID-19?
    Students will learn about infectious disease and the immune response to infection by investigating different types of tests (PCR, antigen, and antibody tests) to detect the SARS-CoV-2 viral genetic...

    Keywords: geneticsVision and Changeintroductory biologyinfectious diseasemolecular biologycore competenciesRT-PCRviruscore conceptsnon-majors biologySARS-CoV-2antibodyAntigenImmunoReachmolecular DiagnosticsCOVID-19 transmission

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    Antibody Binding
    This module introduces the Scatchard equation in the context of understanding antigen binding and the properties of antigens. It is intended for an introductory biology audience.

    Keywords: linear equationshyperbolic equationsCellular Processes

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    How amphibians are impacted by Chytridiomycosis with Keely Rodriguez
    Keely Rodriguez is a Ph.D. student at the University of Nevada Reno in the Ecology, Evolution, and Conservation Biology department. In this interview, Keely discusses her background and her...

    Keywords: Disease ecologyamphibians

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    Migration Assay Protocol
    Migration is a key property of live cells and critical for normal development, immune response, and disease processes such as cancer metastasis and inflammation.

    Keywords: migration assay

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    Vaccine Development and Testing
    Scientists have the tools and knowledge to develop safe, effective vaccines, from trials to vials. This resource addresses the process by which vaccines are designed, tested and regulated. Key...

    Keywords: immunology educationvaccine literacyvaccine hesitancy

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    Using the IEDB to Predict Proteasomal Cleavage Events and T-cell Epitopes
    Research experiences provide a valuable view into the world of science and a great way to explore new fields and careers while developing critical thinking skills. The development and maintenance...

    Keywords: biologydatabaseImmunologydata sciencebioinformaticsBiotechnologyt-cellengineeringantibodyBioengineeringAntibody EngineeringlymphocytesProteinNetChopepitopeIEDBB-cellProteasomeProteasomal Cleavage

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    Assessment: When tests disagree, how do I know if I have COVID-19?
    In this activity, students learned about the immune response to infection by exploring different types of tests—PCR, antigen, and antibody tests—to detect SARS-CoV-2 viral genetic material,...

    Keywords: ImmunologyPCRCOVID19SARS-CoV-2structure and functionImmunoReachantigen-antibody interactionInformation FlowAntigen testAntibody test

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    Fitzhugh-Nagumo Model
    The FitzHugh–Nagumo model describes a prototype of an excitable system (e.g., a neuron).

    Keywords: differential equationsmathematical modeldifferential equation modelordinary differential equation modelneuroscienceexcitable

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    Draft Version: Energy Balance Models
    This module introduces the student to the process of mathematical modeling.

    Keywords: modulemathematical modelingbenergy balanceclimate modelDIMACSResources @ DIMACSclimatein-class activityResources @ QUBES - Teaching & Referencescienceexperiment

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    Let me in: Interpreting graphs of parasite infection in red blood cells
    The goal of this activity is to familiarize students with reading graphs, to think about how cells are different from one another and how parasites can take advantage of cell surface markers to...

    Keywords: graph interpretationfmnCellsStem cellsmalariaBioGraphIrepresentation in STEMcell sortinginfection efficiencycell surface proteinscell recongitionred blood cells

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    A Critical Guide to Unix
    This Critical Guide in the Introduction to Bioinformatics series briefly introduces the Unix Operating System, and provides a subset of some of the most helpful and commonly used commands....

    Keywords: NIBLSEUNIXbasic UNIX commandsGOBLETInstructorResources

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    Electrical Activity of Neurons
    This tutorial describes how neurons generate action potentials, and how scientists measure neuronal activity and record the firing of individual neurons.

    Keywords: Resources @ HHMI - BioInteractiveAnatomy & PhysiologyNervous systemCell communication

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    Transpiration
    In this lab, students will examine differences between C3 and C4 plants in their transpiration rates.

    Keywords: plant physiologybotanylaboratoryResource Type

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