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    Needleman - Wunsch Algorithm Exercise
    This exercise is used in a sophomore-junior level bioinformatics course. The algorithm is introduced to the students who then complete the exercise.

    Keywords: bioinformaticsUndergraduateNIBLSEalgorithmsincubatorsAudience LevelAdvancedActivity Length1 HourNeedleman-WunschC2. Computational conceptsIncubated at NIBLSE

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    2005-Albert_Tarantola-Inverse Problem Theory and Methods for Model Parameter Estimation
    This is a bible of approaches to support parameter estimation approaches in inverse problems. Theory and algorithms are offers with examples.

    Keywords: Algorithminverse probleminverse

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    5-010-MatrixExponential-TechniqueNarrative
    The matrix exponential is a powerful computational and conceptual tool for analyzing systems of linear, constant coefficient, ordinary differential equations (ODE's). This narrative offers a quick...

    Keywords: matrix esponentialPutzer's Algorithmdiagonalizationeigenvalueseigenvectors

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    2012-Nokkaew-EtAl-Estimation of Algae Growth Model Parameters by a Double Layer Genetic Algorithm
    This paper presents a double layer genetic algorithm (DLGA) to improve performance of the information-constrained parameter estimations.

    Keywords: optimizationalgae growthgenetic algorithmssimulated dataconvergence of parameters

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    ABO Blood Group Frequencies
    An Excel workbook in which students can calculate blood type frequencies through different approaches (Hardy-Weinberg, quadratic formula, and the EM algorithm). The workbook shows the formulas...

    Keywords: Hardy-Weinbergblood type frequencies

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    2008-Duran-Caginalp-Parameter optimization for differential equations in asset price forecasting
    The optimization procedure is used in conjunction with daily market prices (MPs) and net asset values to determine the parameters for which the AFDE yield the best fit for the previous n days.

    Keywords: financeinverse problemnumerical nonlinear optimizationasset flowfinancial market dynamicsmarket return prediction algorithm

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    1-155-CruiseControl-ModelingScenario
    In this project we illustrate the design of a proportional-integral-derivative (PID) cruise control algorithm for an automobile. PID control is one of the most common techniques in control...

    Keywords: PID controllerfeedback controlControl theorycruise controlautomobileclosed-loop controlinput-ouputblock diagram

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    A Critical Guide to BLAST
    This Critical Guide in the Introduction to Bioinformatics series provides an overview of the BLAST similarity search tool, briefly examining the underlying algorithm and its rise to popularity.

    Keywords: NIBLSEBLASTGOBLETInstructorResources

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    9-030-WaterHammer-ModelingScenario
    We develop and apply a numerical algorithm that solves a system of two nonlinear partial differential equations (PDEs) that describes the time evolution of the water hammer phenomenon.

    Keywords: Stock and Flow modelhyperbolic equationsfinite differenceswater hammerhydrodynamicscompressibilitywave celerity

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    Protein Analysis
    This Excel workbook allows the analysis of sample or imported protein sequences. The model can analyze protein sequences up to 500 amino acids long.

    Keywords: Protein sequencehydrophobicity/hydrophilicity

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    2009-Shamim-EtAl-Investigating viscous damping using a webcam
    We describe an experiment involving a mass oscillating in a viscous fluid and analyze overdamped, critically damped and underdamped regimes of harmonic motion.

    Keywords: laboratoryunderdampedoverdampedcritically dampedharmonic motionimage processingviscous fluid

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    2011-Radouane_Yafia-A Study of Differential Equations Modeling Malignant Tumor Cells in Competition with Immune System
    In this paper, we present a competition model of malignant tumor growth that includes the immune system response. The model considers two populations: immune system (effector cells) and population...

    Keywords: Immunologytumorhopf bifrucation

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    2001-Edwards-Buckmire-A differential equation model of North American cinematic box-office dynamics
    A new mathematical model is presented for the box-office dynamics of a motion picture released in North America.

    Keywords: cinemamoviesbox-office

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    1992-CHF_Bulte-The differential equation of the deflection curve
    This paper presents the derivation and physical meaning of the general fourth-order linear differential equation (with sectionally continuous derivatives) of the deflection curve and its general...

    Keywords: beamdeflectionshear forcebending momentcritical loadnatural frequency

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    1-030-RandomPerturbation-TechniqueNarrative
    After a brief historical view of this problem, we will demonstrate the derivation of first order linear differential equations with random perturbations.

    Keywords: random perturbationBrownian motionLangevin equationRiemann-Steiltjes integralWiener processIto's calculus

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    6-002-EulerCromerPendulum-ModelingScenario
    This activity introduces students to the concept of numerical stability. While modeling a simple pendulum, students compare performance of the semi-implicit Euler-Cromer method with Euler's method...

    Keywords: pendulumsemi-implicit methodsEuler-Cromernumerical solvers

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    Developing hands-on activities linking plankton and computational thinking
    Poster on computational thinking as a method to help address complex problems, create systems, and understand behaviors presented at the 2018 QUBES/BioQUEST Summer Workshop

    Keywords: computational thinkingplanktonSummer Workshop 2018

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    2018-Adeniji-EtAl-InverseProblemHolling-TannerModel
    We consider the inverse problem of parameter identification of nonlinear system of ODEs for a specific case of complete information about solution of the Holling-Tanner model for finite number of...

    Keywords: goal functionabsolute error curvesinvers methodholling-Tanner model

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    2010-Shianga-EtAl-Computational model of the human glucose-insulin regulatory system
    A computational model of insulin secretion and glucose metabolism for assisting the diagnosis of diabetes mellitus in clinical research is introduced. The

    Keywords: glucose tolerance testsum of squared residualsmultiple shooting methodcost function

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    2003-Richard-Carson-Tracer kinetic modeling in PET
    The use of radiopharmaceuticals and the imaging of their biodistribution and kinetics with modern instrumentation are key components to successful developments in PET.

    Keywords: Metabolismtomographyradiopharmaceuticalspositron emission

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