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    My Dog IS My Homework: Exploring Canine Genetics to Understand Genotype-Phenotype Relationships
    To facilitate understanding of the fundamental genetic concept of the genotype-phenotype relationship in our introductory biology students, we designed an engaging multi-week series of related...

    Keywords: gel electrophoresissequence analysiscanine geneticsdeoxyribonucleic acid (DNA)dog coat morphologygenotype and phenotypemutationsPolymerase chain reaction (PCR)single nucleotide polymorphism (SNP)

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    Doctor in the House: Improving Undergraduate Critical Thinking Skills Through Diagnosing Medical Case Studies
    Students in undergraduate anatomy and physiology courses are not often exposed to clinical examples of homeostatic imbalances, particularly ones that provide an opportunity to diagnose a...

    Keywords: medicinediagnosiscardiovasculardeductive reasoningdigestiveEndocrinehomeostatic imbalancehypothetico-deductive modelurinary

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    A Hands-on Introduction to Hidden Markov Models
    In this Lesson, we describe a classroom activity that demonstrates how a Hidden Markov Model (HMM) is applied to predict a eukaryotic gene, focusing on predicting one exon-intron boundary. This HMM...

    Keywords: transcriptionexonintronsplicing

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    Fruit Fly Genetics in a Day: A Guided Exploration to Help Many Large Sections of Beginning Students Uncover the Secrets of Sex-linked Inheritance
    Moving beyond the basic concepts of autosomal Mendelian inheritance to sex-linkage can be difficult for introductory biology students. Although crosses with Drosophila fruit flies have long been a...

    Keywords: Mendelian Geneticsfruit fly biologysex-linked inheritance

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    Teaching Genetic Linkage and Recombination through Mapping with Molecular Markers
    Most introductory genetics courses cover genetic linkage, a core concept in the CourseSource genetics learning outcome framework. Although it is a classical genetics topic, genetic linkage remains...

    Keywords: meiosisphenotypegel electrophoresismicrosatellitesBanding PatternGenetic linkageInheritanceMolecular MarkersPhysical Linkage

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    Discovering Prokaryotic Gene Regulation by Building and Investigating a Computational Model of the lac Operon
    The ability to construct and reason through a biological system is an important skill to develop in science education. This level of understanding forces students to recognize the interrelatedness...

    Keywords: prokaryotesgene regulationLac Operoninducible operon

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    Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Introductory Biology (identifying new promoters)
    Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression. This laboratory lesson allows students to...

    Keywords: bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein

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    An Active Textbook Converts "Vision and Tweak" to Vision and Change
    Multiple reports over more than a century have documented the problems with the way introductory biology has been taught in most colleges and universities. An influential recent report, Vision and...

    Keywords: Vision and Changeactive learningintroductory biologyFlipped classroomUndergraduatecore competenciescore conceptsactive textbookcurriculum reform

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    A Close-Up Look at PCR
    The Polymerase Chain Reaction (PCR) is a fundamental laboratory technique that allows for the amplification of many copies of a desired DNA target sequence. Despite its prevalence, undergraduate...

    Keywords: PCRDNA replication

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    Serotonin in the Pocket: Non-covalent interactions and neurotransmitter binding
    This lesson introduces beginning biochemistry students to the concept of a biomolecule binding site, such as a neurotransmitter receptor site or an enzyme active site. A simple organic molecule,...

    Keywords: active sitebindingbinding sitehydrogen bondinghydrophobic effectionic interactionsnon-covalent forces

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    2016-Spayd-Puckett- A Three-Fold Approach to the Heat Equation - Data Modeling Numerics
    This article describes our modeling approach to teaching the one-dimensional heat (diffusion) equation in a one-semester undergraduate partial differential equations course.

    Keywords: separation of variablesexperimentheat equationLab Equipmentcollect data

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    Using Immunocytochemistry and Fluorescence Microscopy Imaging to Explore the Mechanism of Action of Anti-Cancer Drugs on the Cell Cycle
    Understanding and visualizing the cell cycle and mitosis is an essential concept of cell biology. This multi-week lab module has students investigate the mechanism of action of anti-cancer drugs...

    Keywords: fluorescence microscopymitosisCell StructureCell ImagingImmunocytochemistryQuantitative microscopySTEM skills

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    Using Structured Decision Making to Explore Complex Environmental Issues
    Environmental issues are inherently complex, often requiring multiple interested parties to come together before agreeing on a solution. Structured decision making is a tool used by federal and...

    Keywords: interdisciplinarysocio-ecological systemsscience policystakeholderstructured decision making

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    Squirrels in Space: Using Radio Telemetry to Explore the Space Use and Movement of Sciurid Rodents
    Biotelemetry is used by researchers to track the interactions of animals with each other and the environment. While advancing technology has led to the development of numerous biotelemetry tools,...

    Keywords: DispersalHabitat selectionHome rangeSquirrel-Net

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    The ACTN3 Polymorphism: Applications in Genetics and Physiology Teaching Laboratories
    Inquiry-based undergraduate laboratories provide the opportunity to engage students in a research experience that improves scientific thinking, but such activities can be difficult to develop and...

    Keywords: protein structure and functionhuman genetic variationmuscle physiology

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    Converting a Face-to-Face Lab to Online: An Example of Process and Outcomes for a CRISPR-Based Molecular Biology Lab
    The COVID-19 pandemic created a need to convert in-person laboratory courses into an online format in a short amount of time. For this reason, we converted our face-to-face molecular biology lab...

    Keywords: mutationtranscriptioncrisprtranslation

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    A Short Laboratory Module to Help Infuse Metacognition during an Introductory Course-based Research Experience
    A core competency identified in Vision and Change for undergraduate biology students is the Ability to Apply the Process of Science. Here, we describe a three-week laboratory module for students in...

    Keywords: metacognitiongene expressionScientific ProcessExperimenal DesignHypothesis Generationmodel organisms

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    Building a Model of Tumorigenesis: A small group activity for a cancer biology/cell biology course
    The multistep nature of tumorigenesis is a foundational concept in the context of Cancer Biology. Many students do not appreciate the complex nature of cancer development nor do they understand how...

    Keywords: pathwayscancerMolecular AlterationsRetrospective dataTumorigenesis

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    A CURE-based approach to teaching genomics using mitochondrial genomes
    There is an abundance (currently over 1016 DNA bases) of publicly available genetic sequence data and a dearth of trained genomicists to process and interpret it, necessitating more trained...

    Keywords: proteinsMitochondrial GenomesNuclear GenomesrRNAtRNA

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    Drawing flowcharts of lab protocols helps students prepare for biology labs
    With the publishing of the Vision and Change report, we know it is best practice to include authentic research experiences in our undergraduate science lab classes. One big challenge in teaching...

    Keywords: laboratorymolecular biologyUndergraduateprotocolflowchart

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