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    2015-G_Knott-Chemical Kinetics - Simple Binding F + G to and from B
    The study of this reaction, F + G goes to and from B, is common in chemistry and biochemistry. For example, F could be a hormone or drug and G the associated receptor sites.

    Keywords: bindingreactionchemical kineticsdeterministicBiochem Labsprobabilistickinetic reaction

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    2012-Campbell-EtAl-Parameter estimation in differential equation models with constrained states
    We introduce a method to estimate parameters and states from a differential equation model while enforcing interpretability constraints such as monotone or non‐negative states.

    Keywords: chemical engineeringsmoothing-based relaxation method

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    2011-Brian_Winkel-Sourcing_for_parameter_estimation_and_study_of_logistic_differential_equation
    We present two simulation activities for students to generate real data and several data sources for the purpose of estimating parameters in the logistic differential equation model.

    Keywords: dataparameter estimationparameterlogistic equationsource

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    2009-Brian_Winkel-Population_modelling_with_MandMs
    Several activities in which population dynamics can be modeled by tossing M&M’s® candy are presented.

    Keywords: simulationparameter estimationimmigrationdeathdifference equation

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    2012-Transtrum-Qiu-Optimal experiment selection for parameter estimation in biological differential equation models
    We explore the question to what extent parameters can be efficiently estimated by appropriate experimental selection.

    Keywords: experimental designsystems biologyAssociation & Data Fittingreaction ratesdecay rates

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    1999-Khorasheh-Ahmadi-Gerayeli-Application of Direct Search Optimization for Pharmacokinetic Parameter Estimation
    For simple pharmacokinetic compartmental models, analytical solution to the governing differential equations provide a mean to evaluate the associated rate constants. Such methods, however, can not...

    Keywords: sum of square errorsleast squarespharmacokineticslineteicscompartmental modelsdirect search

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    2007-Helfgott-Seier-Some Mathematical and Statistical Aspects of Enzyme Kinetics
    We will analyze some basic ideas behind enzyme kinetics, which allow us to deal with separable and linear differential equations as well as realize the need to use power series.

    Keywords: kineticsEnzymeexperimental dataregresion

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    2004-Aldo_Rescigno-On the use of pharmacokinetic models
    In this paper I will define in a simple and logical way a set of useful pharmacokinetic parameters and show how their estimation depends on the assumed model.

    Keywords: compartmentsteady statepharmacokineticsvolume distribution

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    2009-Brian_Winkel-Modelling_Growth_Of_an_OilSlick
    An oil-slick spreads at sea. From time to time, but irregularly, a helicopter is dispatched. On each trip, it arrives over the slick, the pilot takes a picture, waits 10 minutes, takes another, and...

    Keywords: differential equationssimulationparameter estimationdifference equation

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    5-012-LipoproteinModeling-ModelingScenario
    Data from a study on the amounts of low-density-lipoprotein (LDL), form of cholesterol, in blood plasma is presented. Students build, validate, and use a compartment model of the kinetic...

    Keywords: wildlifelow-density-lipoproteintracercompartment modelcholesterolblood plasmabody tissue

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    2012-Nokkaew-EtAl-Estimation of Algae Growth Model Parameters by a Double Layer Genetic Algorithm
    This paper presents a double layer genetic algorithm (DLGA) to improve performance of the information-constrained parameter estimations.

    Keywords: optimizationalgae growthgenetic algorithmssimulated dataconvergence of parameters

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    2010-Shianga-EtAl-Computational model of the human glucose-insulin regulatory system
    A computational model of insulin secretion and glucose metabolism for assisting the diagnosis of diabetes mellitus in clinical research is introduced. The

    Keywords: glucose tolerance testsum of squared residualsmultiple shooting methodcost function

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    1999-Meyer-Ausubel-Carrying Capacity-A Model with Logistically Varying Limits
    This paper extends the logistic equation to simple growth model with a logistically increasing carrying capacity. This is applied to human population situations in several countries with fits to data.

    Keywords: population dynamicsparameter estimationlimited growthgrowthlogisitic

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    1994-S_S_Everingham-C_Peter_Rydell-Modeling the Demand for Cocaine
    This is a report prepared for the Office of National Drug Control Policy of the United States Army by the Rand Corporation. The report contains lots of data and builds a two compartment difference...

    Keywords: drugstwo compartmentcocainedemand

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    2011-Brian_Winkel-Parameter_Estimates_in_Differential_Equation_Models_for_Chemical_Kinetics
    We estimate the parameters present in several differential equation models of chemical kinetics and logistic growth.

    Keywords: kineticsparameter estimationlogisticchemical kineticschemical reaction

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    2011-Brian_Winkel-Parameter_Estimates_in_Differential_Equation_Models_for_Population_Growth
    We estimate the parameters present in several differential equation models of population growth, specifically single species exponential and logistic growth, and multiple species competition and...

    Keywords: population modelparameter estimationpopulationparameter

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    2015-Brian_Winkel-Informed_Conjecturing_of_Solutions_for_Differential_Equations_In_a_Modeling_Contex
    We examine (1) first order exponential growth or decay and (2) second order, linear, constant coefficient differential equations, and show the advantage of learning differential equations in a...

    Keywords: exponential growthsolutionslinear systemsdecayconjecture

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    1957-Axelrod_ Brady_Witkop_Evarts-The Distribution and Metabolism of Lysergic Acid Diethylamide
    The development of a specific and sensitive method for the estimation of LSD in biological materials has enabled us to study the tissue distribution, excretion, rate of biotransformation, and...

    Keywords: mathematical modeldataLSDMetabolismbloodstreamlysergic acid diethylamidedistribution

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    1-018-LogisticPopModel-ModelingScenario
    We offer artificial (toy) and historical data on limited growth population situations in the study of protozoa and lead students through several approaches to estimating parameters and determining...

    Keywords: data analysisparameter estimationlogisticCiliate protozoapopulationlimited growthparameciaGause

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    1968-Wagner-Aghajanian-Bing-Correlation of performance test scores with tissue concentration of lysergic acid diethylamide
    This paper offers a two compartment model of lysergic acid diethylamide (LSD) in volunteer students and through parameter estimation models the amount of LSD in the tissue after its initial...

    Keywords: LSDcorrelation coefficientcompartment modellysergic acid diethylamideperformancetest scoretissue concentration

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