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    Mendelian Genetics, Probability, Pedigree, and Chi-Squared Statistics
    A lesson that requires students to work through a series of questions pertaining to the genetics of sickle cell disease and its relationship to malaria.

    Keywords: geneticsResources @ HHMI - BioInteractiveScientific ProcessStatistics and Mathmendelian inheritance

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    2020-TeachingModule-SpreadOfCommonColdSimulation
    This simulation is meant to introduce the idea of a differential equation model and investigate the impact of heightened hygiene and decreased interactions on the spread of an infectious disease....

    Keywords: simulationmoduleinfectious diseasediseasespreadTeaching Modulespread of disease

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    SIR BuildIt
    An introduction to epidemiological models using interactive Excel worksheets

    Keywords: epidemiologymodelingTeaching Material @ BioQUEST_ESTEEMExcelinfectious diseaseInfectious Disease ModelingSIR modelsSIR

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    Furry with a chance of evolution: Exploring genetic drift with tuco-tucos
    Genetic drift is an important mechanism of evolution, yet undergraduates often fail to understand how it leads to evolutionary change due in part to its random nature. This lesson plan describes a...

    Keywords: EvolutionGenetic DriftBottle neckFounder effectRandom evolutionary processes

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    Honoring the Complexity of Genetics: Exploring the Role of Genes and the Environment Using Real World Examples
    Historically, undergraduate genetics courses have disproportionately focused on the impact of genes on phenotypes, rather than multifactorial concepts which consider how a combination of genes, the...

    Keywords: genesenvironmentMendelQuantitative traitsMultifactorialGene by environment interactions

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    Implementing active learning approaches into an upper-division biology course
    In this essay, we present our strategy for implementing active learning strategies into an upper division course on Human Genetics. Our principal goal was to shift from a traditional didactic...

    Keywords: human biologyPedigree analysisRare genetic diseases

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    2015-Just-Callender-Differential equation models of disease transmission
    The work give full analyses of standard epidemic model and then shows how to do it with differential equations and agent-based modeling. Then it compares the results.

    Keywords: disease transmissionSIR modelsepidemicagent-based

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    1-017-DiseaseSpread-ModelingScenario
    Using a grid and m&m candies, we simulate the spread of disease. Students conduct the simulation and collect data to estimate parameters (in several ways) in a differential equation model for the...
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    From Cre/LoxP to Fate Maps: Inclusive and Equitable Approaches for Engaging Developmental Biology Students in Experimental Design
    Engaging first generation underrepresented minority students in the process of inquiry in developmental biology is important to increase diversity in future graduate STEM education. One important...

    Keywords: experimental designC. elegansCre/LoxPFate mapheart developmentheart regenerationmousereporter constructzebrafish

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    Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
    There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has...

    Keywords: bioinformaticscancertranscriptomicshigh-throughputData wranglingSingle cell RNA sequencingq

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    2011-Yanyu_Xiao-Study of Malaria Transmission Dynamics by Mathematical Models
    The novelty lies in the fact that different distribution functions are used to describe the variance of individual latencies. The theoretical results of this project indicate that latencies reduce...

    Keywords: infectious diseaseinfectionmalarialatencyspatial dispersalmulti-species

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    2016-Manheim-EtAl-Improving Decision Support for Infectious Disease Prevention and Control
    This report describes decision-support tools, including models and nonmodeling approaches, that are relevant to infectious disease prevention, detection, and response and aligns these tools with...

    Keywords: infectious diseaseecosystemepidemicmodel policy

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    2010-Jungck-EtAl-Mathematical Manipulative Models-In Defense of Beanbag Biology
    This paper offers up samples of projects from the Bio- QUEST Curriculum Consortium’s 24-yr experience of holding faculty development workshops for biology and mathematics educators.

    Keywords: epidemiologysimulationinfectious diseasedisease transmissiondiseasein-class activitybean bag activity

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    Molecular Basis of Sickle Cell Disease
    This multi part case on hemoglobin structure as it relates to oxygen binding and sickle cell disease focuses on utilizing bioinformatics and molecular visualization tools to learn about the sickle...

    Keywords: Hemoglobinmolecular visualization and analysisintroductory bioinformaticssickle cell diseasePDBMolecular Case Studyoxygen bindingmyoglobinmolecular literacy3D protein structuresstructural representations

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    A CURE for Salmonella: A Laboratory Course in Pathogen Microbiology and Genomics
    Rapid advances in genomics and bioinformatics, the vast amount of data generated by next-generation sequencing, and the penetration of the ‘-omics’ into many areas of biology have created a need...

    Keywords: epidemiologyresearchbioinformaticsgenomicspublic healthAntibiotic Resistant BacteriaSalmonellaDNA sequencingpathogenic bacteria

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    Fragile States: A Case Study Exploring Genetics, Molecular Biology, and Biochemistry Through the Lens of Fragile X Syndrome
    This case aims to strengthen students’ understanding of molecular biology concepts through study of Fragile X Syndrome (FXS). Students begin by learning the cause and phenotypes of FXS and...

    Keywords: gene regulationtranscriptiontranslationFragile X syndrometriplet repeat expansionsex linkagemetabolic pathway

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    Cell Signaling Pathways - a Case Study Approach
    Signaling and gene expression are fundamental to cell biology and developmental biology. Although these topics are highly interrelated, they typically appear in separate units in a course. We use a...

    Keywords: signal transductiongene expressionCell communicationgenetic disordersregulation of enzyme activity

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    Using Collaborative Projects to Promote Active Learning of Microbial Skin Diseases and Their Impact on Everyday Lives
    One of the most daunting aspects of introductory clinical microbiology is learning details about a vast number of different microbial diseases that can infect humans. Each of these diseases has...

    Keywords: infectious diseasecollaborationpathogenesisTreatment of diseasesReal-life Microbiology

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    Predicting and classifying effects of insertion and deletion mutations on protein coding regions
    Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of...

    Keywords: mutationcentral dogmatranslationframeshift

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    Fly Exercise: A Simple Experiment to Test the Physiological Effects of Exercise on a Model Organism
    Model organisms are commonly used to study and experimentally explore biological processes in ways that are technically or ethically not possible in humans. For this reason, model organisms are an...

    Keywords: exerciseenzyme kineticsmetabolite concentrationmodel speciesphysical activity

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