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    Sanger Sequencing by Hand: Using Paper Clips to Demonstrate Chain Termination
    Sanger sequencing is commonly taught with a hands-on approach. Sanger sequencing involves chain termination by dideoxynucleotides, because they are missing the oxygen on the 3’ carbon atom,...

    Keywords: nucleotidessequencingDNAgel electrophoresisChain Termination

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    A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation
    Mutations in genes can lead to a variety of phenotypes, including various human diseases. Students often understand that a particular mutation in a single gene causes a disease phenotype, but it is...

    Keywords: mutationProtein Structureethicscentral dogmahuman disease

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    Making Change Sustainable: Network for Integrating Bioinformatics into Life Sciences Education (NIBLSE) Meeting Review
    The purpose of the meeting described in this review was to decide how best to ensure the sustainability of the Network for Integrating Bioinformatics into Life Science Education (NIBLSE; pronounced...

    Keywords: meetingsustainabilityfmnNIBLSEincubator

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    The Science Behind the ACTN3 Polymorphism
    A common polymorphism in the alpha-actinin-3 (ACTN3) gene results in the lack of ACTN3 protein expression in fast twitch muscle fibers in ~16% of the human population (1). This genetic change has...

    Keywords: protein structure and functionhuman genetic variationskeletal muscle physiology

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    A Strategy for Teaching Undergraduates to Write Effective Scientific Results Sections
    Most undergraduate instructors would agree that learning to write about data in the style of a scientific research paper is a worthy goal for their students.  However, many hesitate to tackle...

    Keywords: data analysisprimary literaturescientific writingcommunicating science

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    A Hands-on Introduction to Hidden Markov Models
    In this Lesson, we describe a classroom activity that demonstrates how a Hidden Markov Model (HMM) is applied to predict a eukaryotic gene, focusing on predicting one exon-intron boundary. This HMM...

    Keywords: transcriptionexonintronsplicing

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    Drawing “Octo-Pines”: Ice-Breaker Active-Learning Activities to Introduce Drawing-to-Learn in Biology
    Drawing has been advocated as a technique to develop visual literacy and observational skills in biology students. To increase student motivation and confidence to draw in our course, we developed...

    Keywords: Zoologydrawingdrawing-to-learnice breaker

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    A Laboratory Module That Explores RNA Interference and Codon Optimization Through Fluorescence Microscopy Using Caenorhabditis elegans
    Scientific research experiences are beneficial to students allowing them to gain laboratory and problem-solving skills, as well as foundational research skills in a team-based setting. We designed...

    Keywords: microscopyC. elegansquantitative analysisinquiry-based learninggene expressionRNA interferenceCodon UsageLaboratory Module

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    Using Immunocytochemistry and Fluorescence Microscopy Imaging to Explore the Mechanism of Action of Anti-Cancer Drugs on the Cell Cycle
    Understanding and visualizing the cell cycle and mitosis is an essential concept of cell biology. This multi-week lab module has students investigate the mechanism of action of anti-cancer drugs...

    Keywords: fluorescence microscopymitosisCell StructureCell ImagingImmunocytochemistryQuantitative microscopySTEM skills

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    An Interactive Protocol for In-Classroom DNA Extraction
    Using commonly available materials, this tool allows students to extract DNA, exploring DNA chemistry and the principles of experimental design and execution. We take a “Choose Your Own...

    Keywords: geneticsDNAbiochemical structure and function

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    My Fish Tank: An Active Learning Activity for Bacterial Nitrogen Metabolism
    This active learning activity introduces students to the second part of the nitrogen cycle, nitrification. In terrestrial and aquatic environments, bacteria from the Nitrosomonas and Nitrobacter...

    Keywords: nitrogen cyclenitrificationnitrifying bacteria

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    Pick Your Poison: A Semester-Long Case Study for Undergraduate Toxicology
    The ability to collate information from diverse scientific resources and effectively employ scientific writing is an essential skill for scientists. This lesson describes a semester-long project...

    Keywords: risk assessmenttoxicologyPharmacologyregulationsdose responseADME

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    Responsible and Ethical Conduct of Research: Instruction on Plagiarism
    Helping students understand where they should provide citations in research manuscripts is an essential aspect of training them in the responsible and ethical conduct of research. This Lesson...

    Keywords: citationwritingethicsplagiarismparaphrasequote

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    An Introduction to the Squirrel-Net Teaching Modules
    Although course-based undergraduate research experiences (CUREs) are gaining popularity in biology, most are designed for benchwork-based laboratory courses while few focus on field-based skills....

    Keywords: ecologybehaviortrade-offsScientific ProcessSquirrel-Net

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    Science Behind the Lesson: It's a Bird! It's a Plane! It's Biomechanics!
    Active flight is a specialized mode of movement found in insects, birds, and mammals. The anatomy, morphology, physiology, and ecology of flying taxa has changed over evolutionary time. Researchers...

    Keywords: EvolutionecologybatphysiologyAnatomybiomechanicsbirdFlightinsect

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    The Pipeline CURE: An Iterative Approach to Introduce All Students to Research Throughout a Biology Curriculum
    Participation in research provides personal and professional benefits for undergraduates. However, some students face institutional barriers that prevent their entry into research, particularly...

    Keywords: epigeneticsundergraduate researchmendelian inheritanceSelf-EfficacyCUREsnature of scienceResiliencecurriculum strategiesreprogramming

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    Strategies for developing a science communicator through authentic science writing assignments
    To prepare biology undergraduates to be able to read and evaluate the primary literature, it is beneficial to teach students how to write documents in the style of professional science style...

    Keywords: communicationPeer reviewscience writing

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    Thinking deeply about quantitative analysis: Building a Biologist's Toolkit
    Vision and Change in Undergraduate Biology Education encouraged faculty to focus on core concepts and competencies in undergraduate curriculum. We created a sophomore-level course, Biologists'...

    Keywords: Vision and ChangeRRStudioquantitative literacystatistical analysisScientific communication

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    An Open Source, Collaborative Electronic Notebook for Undergraduate Laboratory Classes
    To overcome many of the limitations of the paper laboratory notebook (PLN), we developed an electronic laboratory notebook (e-LN) for the Dynamic Genome course at the University of California. The...

    Keywords: data collectionData annotationNotebook Skills

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    Why Meiosis Matters: The case of the fatherless snake
    A compelling reason to learn something can make all the difference in students’ motivation to learn it.  Motivation, in turn, is one of the key attitudes that drives learning.  This story...

    Keywords: meiosismitosissex determinationAsexual reproductionParthenogenesis

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