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    The Science Behind the ACTN3 Polymorphism
    A common polymorphism in the alpha-actinin-3 (ACTN3) gene results in the lack of ACTN3 protein expression in fast twitch muscle fibers in ~16% of the human population (1). This genetic change has...

    Keywords: protein structure and functionhuman genetic variationskeletal muscle physiology

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    Teaching the Biological Relevance of Chemical Kinetics Using Cold-Blooded Animal Biology
    This lesson plan was created to support non-chemistry major students in making connections between chemical kinetics and biological systems. Chemical kinetics is often viewed by students as an...

    Keywords: kineticsMetabolismEctothermPoikilotherm

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    Forensic Phylogenetics: Implementing Tree-thinking in a Court of Law
    Here we describe an in-class activity developed for Evolutionary Biology and Biodiversity (BioEE1780) at Cornell University, an introductory course required of all biology majors. This activity...

    Keywords: phylogeneticsTree thinkingparaphyly

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    Tackling "Big Data" with Biology Undergrads: A Simple RNA-seq Data Analysis Tutorial Using Galaxy
    Analyzing high-throughput DNA sequence data is a fundamental skill in modern biology. However, real and perceived barriers such as massive file sizes, substantial computational requirements, and...

    Keywords: bioinformaticsDNA sequenceRNAseqgene expression

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    Learning to Pipet Correctly by Pipetting Incorrectly?
    Beginning undergraduate students in biology need basic laboratory, data analysis, and science process skills to pursue more complex questions in course-based undergraduate research experiences...

    Keywords: statisticslaboratorypipetting

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    Dynamic Daphnia: An inquiry-based research experience in ecology that teaches the scientific process to first-year biologists
    This authentic research experience lesson teaches the core concept of systems and the competencies of quantitative reasoning, communication, and the ability to apply science. The research is...

    Keywords: statisticsecologyscientific methodexperimental designAbiotic and Biotic FactorsDependent and Independent Variables

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    How to Design a Classroom Activity that Integrates 3D Print Models with Active Learning
    Student exploration of relevant physical models can deepen knowledge of course material. In this guide we describe a method by which instructors can integrate 3D printing technology with an...

    Keywords: active learning3D print modelsclassroom jigsaw

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    Priority Setting in Public Health: A lesson in ethics and hard choices
    Undergraduate life sciences majors, many of whom aspire to work in healthcare and health research, can benefit from early exposure to ethical issues that they may encounter in these careers. This...

    Keywords: public health ethicsramifications of one's decisionsrole of science in society

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    A simple way for students to visualize cellular respiration: adapting the board game MousetrapTM to model complexity
    Lecture-based introductory biology courses are typically content-heavy as instructors strive to provide students with foundational knowledge in a broad range of topics.  One topic...

    Keywords: ATPGlycolysisCellular RespirationElectron Transport ChainKrebs Cycle

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    Promoting Climate Change Literacy for Non-majors: Implementation of an atmospheric carbon dioxide modeling activity as an inquiry-based classroom activity
    Students who are directly involved in scientific activities develop a deeper understanding and appreciation of both scientific knowledge and the scientific process. This understanding is critically...

    Keywords: modelingExcelquantitativeclimate changeEnvironmental Biologyatmospheric carbon dioxide

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    Resources for Assessing Educational Interventions in Biology at the Collegiate Level
    Most scientific research is judged based on the quality of controlled experiments and carefully analyzed results. In addition, proper levels of regulation in terms of biosafety and animal usage are...

    Keywords: researchassessmentpedagogylearning gainsIRBregulatory compliance

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    Air Quality Data Mining: Mining the US EPA AirData website for student-led evaluation of air quality issues
    Air pollution directly affects human health endpoints including growth, respiratory processes, cardiovascular health, fertility, pregnancy outcomes, and cancer. Therefore, the distribution of air...

    Keywords: data miningenvironmental justiceair qualityairpollutionspatial reasoning

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    A Hands-on Introduction to Hidden Markov Models
    In this Lesson, we describe a classroom activity that demonstrates how a Hidden Markov Model (HMM) is applied to predict a eukaryotic gene, focusing on predicting one exon-intron boundary. This HMM...

    Keywords: transcriptionexonintronsplicing

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    Plotting Cranial and Spinal Nerve Pathways in a Human Anatomy Lab
    Hands-on experiences with cadavers, animal dissections, or plastic models are effective at improving student learning and attitudes in human anatomy courses. The hands-on experience allows students...

    Keywords: human anatomyNervous systemBrainCranial nerveNerveSpinal cordSpinal nerve

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    From Dirt to Streptomyces DNA
    The purpose of this semester-long Lesson is to give students an authentic, course-based undergraduate research experience during which they learn basic and advanced microbiological and molecular...

    Keywords: MetabolismAntibiotic productionrRNA genesSecondary metabolitesStreptomyces

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    Three Research-Based Quantitative Reasoning Modules for Introductory Organismal Biology Laboratories
    We have designed three laboratory modules for an introductory organismal biology course with an emphasis on quantitative reasoning and data analysis skills. Module 1 tests for dimorphism in...

    Keywords: allometryplantsAnatomytranspirationdimorphisminvertebrate biologyarthropodsplatyhelminths

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    A Laboratory Module That Explores RNA Interference and Codon Optimization Through Fluorescence Microscopy Using Caenorhabditis elegans
    Scientific research experiences are beneficial to students allowing them to gain laboratory and problem-solving skills, as well as foundational research skills in a team-based setting. We designed...

    Keywords: microscopyC. elegansquantitative analysisinquiry-based learninggene expressionRNA interferenceCodon UsageLaboratory Module

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    Teaching Advanced Concepts in Regulation of the Lac Operon With Modeling and Simulation
    Success in biochemistry and other life science courses requires that students understand important biological concepts. One of these concepts is how gene regulation ensures that homeostasis is...

    Keywords: gene regulationinducible operonProkaryotic cellPhosphoenolpyruvate transferase system (PTS)

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    Investigating Cell Signaling with Gene Expression Datasets
    Modern molecular biology is a data- and computationally-intensive field with few instructional resources for introducing undergraduate students to the requisite skills and techniques for analyzing...

    Keywords: genomicstranscriptionsignaling

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    Using Place-Based Economically Relevant Organisms to Improve Student Understanding of the Roles of Carbon Dioxide, Sunlight, and Nutrients in Photosynthetic Organisms
    Biology students require broad preparation for diverse careers including agriculture, natural resource management, and laboratory research. Concurrent with this need, employers are seeking...

    Keywords: energyphotosynthesisbiomass

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