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    The p53 Gene and Cancer
    This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer.

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymolecular biologymacromoleculesGenetic disease

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    Why do Some People Inherit a Predisposition to Cancer? A small group activity on cancer genetics
    Before undergraduate students take a genetics course they generally know cancer has a genetic basis and involves the proliferation of cells; however, many are uncertain about why only a subset of...

    Keywords: cancerInheritance patternsProbability calculationProto-oncogeneTumor Suppressor Gene

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    Using Raw Sequence Data to Analyze Tumor Suppressor Mutations
    Learning to identify DNA sequence variants from raw sequencing data (electropherograms) is a basic molecular biology skill with applications to basic research and clinical practice. Yet learning to...

    Keywords: bioinformaticsmutationDNAgenomic visualizationparts of a geneclinical consequencesraw data

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    Splicing it Together: Using Primary Data to Explore RNA Splicing and Gene Expression in Large-Lecture Introductory Biology
    At the heart of scientific ways of knowing is the systematic collection and analysis of data, which is then used to propose an explanation of how the world works. In this two-day module, students...

    Keywords: gene regulationtranscriptiongene expressioncentral dogmarepressoralternative splicingmRNA processingActivatorTranscription factors

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    Metastatic Mastery: A Case and Game-Based Approach to Learning About Cancer Mechanisms
    Mechanisms that contribute to the development of cancer are numerous and complicated, though most can be traced to a set of mutations in cell cycle regulatory genes that throw the process of cell...

    Keywords: mutationcancertranscriptioncell cycletranslationOncogenesTumor-suppressorp53Transcription factor

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    Building a Model of Tumorigenesis: A small group activity for a cancer biology/cell biology course
    The multistep nature of tumorigenesis is a foundational concept in the context of Cancer Biology. Many students do not appreciate the complex nature of cancer development nor do they understand how...

    Keywords: pathwayscancerMolecular AlterationsRetrospective dataTumorigenesis

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    2016-Wilkie-EtAl-Using ODEs to Explore Cancer-Immune Dynamics and Tumor Dormancy
    Here we present a general method using ordinary differential equations (ODEs) to model and analyze cancer-immune interactions, and in particular, immune-induced tumor dormancy.

    Keywords: cancertumor-inhibiting cytotoxic actiontumor-promoting inflammationimmune-induced tumor dormancytumor growth dynamics

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    2018-Dyjuan_Tatro-The_Mathematics_of_Cancer-Fitting_Gompertz_Equation_to_Tumor_Growth
    Fitting the Gompertz Model to long term breast cancer study data, this project ascertains gompertzian parameters that can be used to predicts tumor growth as a function of time.

    Keywords: tumorgrowthGompertzfittingparameter

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    2014-Enderling-Chaplain-Mathematical Modeling of Tumor Growth and Treatment
    Herein we describe fundamentals of mathematical modeling of tumor growth and tumor-host interactions, and summarize some of the seminal and most prominent approaches.

    Keywords: cancertumor modelingangiogenesistumor growthpatient care

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    2011-Radouane_Yafia-A Study of Differential Equations Modeling Malignant Tumor Cells in Competition with Immune System
    In this paper, we present a competition model of malignant tumor growth that includes the immune system response. The model considers two populations: immune system (effector cells) and population...

    Keywords: Immunologytumorhopf bifrucation

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    GMC: Genes, Mutations and Cancer - Group Concept Map Development
    It has been shown that active learning strategies used in the classroom can increase student learning and retention of information. We generated an active learning exercise that can be used in the...

    Keywords: mutationcancerCell Division

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    Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
    There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has...

    Keywords: bioinformaticscancertranscriptomicshigh-throughputData wranglingSingle cell RNA sequencingq

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    2012-José_Sérgio_Domingues-Gompertz Model - Resolution and Analysis for Tumors
    The main objective of this paper is to use the Gompertz equation in order to study the development of blood irrigated solid tumors, using parameters defined in some important bibliographic...

    Keywords: tumorGompertz equationgrowth tumor

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    2015-Beier-EtAl-Building Context with Tumor Growth Modeling Projects in Differential Equations
    Here we present two projects related to tumor growth appropriate for a first course in differential equations. They illustrate the use of problem-based learning to reinforce and extend course...

    Keywords: tummor growthresearch experience

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    2015-Khan-EtAl-How differential equations influence the tumor growth via mathematical models
    This work demonstrates the importance of differential equations to develop mathematical model of tumor growth.

    Keywords: tumorcancdercancerous cellsimmunotherapymalignant

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    2015-European_Bioinformatics_Institute-Bio-Models-Database
    Bio Models Database is a repository of computational models of biological processes. Models described from literature are manually curated and enriched with cross-references. All models are...

    Keywords: biologydatabasebioinformaticsModelscomputational models

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    2015-Heiko_Enderling-Integrating experimental data to calibrate quantitative cancer models
    For quantitative cancer models to be meaningful and interpretable the number of unknown parameters must be kept minimal. We focus on a tumor hierarchy of cancer stem and progenitor non-stem cancer...

    Keywords: cancertumorfittingagent-based

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    1999-T_Chen-HL_He-GM_Church-S_Shafer-Modeling Gene Expression with Differential Equations
    The paper proposes and give great detail for a differential equation model for gene expression with two methods for constructing the model from a set of temporal data.

    Keywords: gene expressiongenekineticgene translationgene transcription

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    Cell Signaling Pathways - a Case Study Approach
    Signaling and gene expression are fundamental to cell biology and developmental biology. Although these topics are highly interrelated, they typically appear in separate units in a course. We use a...

    Keywords: signal transductiongene expressionCell communicationgenetic disordersregulation of enzyme activity

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    1-081-TumorGrowth-ModelingScenario
    Students will transform, solve, and interpret a tumor growth scenario using non-linear differential equation models. Two population growth models (Gompertz and logistic) are applied to model tumor...

    Keywords: logisticpopulationtumorGompertz

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