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    A Hands-on Introduction to Hidden Markov Models
    In this Lesson, we describe a classroom activity that demonstrates how a Hidden Markov Model (HMM) is applied to predict a eukaryotic gene, focusing on predicting one exon-intron boundary. This HMM...

    Keywords: transcriptionexonintronsplicing

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    A Structured Inquiry-Based Module for the Undergraduate Cell Biology Laboratory That Teaches Fundamental Concepts of Cell Differentiation
    Pedagogical research in science education has shown that students effectively learn science by doing science. As a result, there is increased interest in bringing research-like experiences into the...

    Keywords: fluorescence microscopygene expressionpolymerase chain reactionCell Structurecell culturewestern blottingdifferentiationreverse transcription

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    Drawing “Octo-Pines”: Ice-Breaker Active-Learning Activities to Introduce Drawing-to-Learn in Biology
    Drawing has been advocated as a technique to develop visual literacy and observational skills in biology students. To increase student motivation and confidence to draw in our course, we developed...

    Keywords: Zoologydrawingdrawing-to-learnice breaker

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    Design Your Own Flow Cytometry Experiment: A Four-Week Inquiry Laboratory
    Due to its importance to the field, flow cytometry should be one of the hallmark methods a student learns in the lab portion of an undergraduate immunology course. Flow cytometry is a classic lab...

    Keywords: Immunologyexperimental designFlow cytometryMice

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    Converting a Face-to-Face Lab to Online: An Example of Process and Outcomes for a CRISPR-Based Molecular Biology Lab
    The COVID-19 pandemic created a need to convert in-person laboratory courses into an online format in a short amount of time. For this reason, we converted our face-to-face molecular biology lab...

    Keywords: mutationtranscriptioncrisprtranslation

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    A CRISPR/Cas Guide RNA Design In Silico Activity
    CRISPR biotechnologies inspired by the Clustered Regularly Interspaced Short Palindromic Repeat RNA-guided nuclease adaptive bacterial immune system have revolutionized biology research and become...

    Keywords: bioinformaticsgene expressiongenetic basis of diseaseCRISPR/Cas9genetic engineeringin silico

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    Using CRISPR-Cas9 to teach the fundamentals of molecular biology and experimental design
    One of the challenges of inquiry-based research experiences is balancing the instruction on skills and techniques with data generation and analysis. This is especially true in technique heavy...

    Keywords: experimental designcrisprmolecular technique

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    The Leaky Neuron: Understanding synaptic integration using an analogy involving leaky cups
    Students have difficulty understanding synaptic integration in neural circuits, and how spatial and temporal summation combine in a target neuron to reach threshold.  This Lesson uses small...

    Keywords: neuron physiologyspatial summationsynaptic integrationtemporal summationthreshold

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    Using Yeast to Make Scientists: A Six-Week Student-Driven Research Project for the Cell Biology Laboratory
    Traditionally-trained undergraduate students often lack an understanding of science as an active process that yields the information presented in their textbooks. One result has been a call for...

    Keywords: yeastgrowth curvecell proliferationviability

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    Exploring the City of Biofilms: An Engaging Analogy-Based Activity for Students to Learn Biofilms
    Multicellular biofilms constructed by microbes are key aspects of microbiology with significant implications in various fields, including medicine, environmental science, and biotechnology. While...

    Keywords: bacteriaBiofilmsquorum sensing

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    Exploring the Complexities of Photosynthesis Through a Comic Strip
    Photosynthesis is a conceptually challenging topic. The small scale at which photosynthesis takes place makes it difficult for students to visualize what is occurring, and students are often...

    Keywords: photosynthesislight-dependent reactionsCalvin cyclechloroplast

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    Integrating Community Ecology Into the Study of Parasites: Exploring the Effect of Host Behavior on Parasite Transmission Rates
    Organismal life cycles are often presented as a set of facts to memorize in undergraduate biology courses. This approach is cognitively demanding for students and fails to convey how central life...

    Keywords: statisticsspecies interactionsQuantitative reasoninggraphsCommunity EcologyParasitologyfood webs

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    Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging
    Organelle structure has been studied and visualized for decades; however, publicly available databases that use improved high-throughput microscopy of gene-edited cell lines have recently...

    Keywords: modelingcase studymicroscopystructureOrganellesHigh-throughput (HT)Endoplasmic Reticulum (ER)Fluorescent microscopyHuman Cell Biology

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    Developing Decolonial Consciousness in Biology Students Through Critical Reflection Assignments
    There is a growing call to decolonize curricula in academia, including in scientific disciplines. In the biology classroom, this includes highlighting a diverse array of scientists and illuminating...

    Keywords: primatessocietyZoologyantiracismdecolonizingstudent activismmuseum science

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    Teaching Cell Structures through Games
    As the basic unit of life, cells are a foundational concept for all of biology. Before students can appreciate how eukaryotic cells function either in isolation or in higher order and multicellular...

    Keywords: Cell Structurecell organellesTransmembrane Transport

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    It's a bird! It's a plane! It's biomechanics!
    Biomechanics is a discipline that draws from physics and engineering principles to understand the movement and structure of living organisms. It is highly interdisciplinary in nature and can be...

    Keywords: EvolutionecologybatphysiologyAnatomybirdFlightforcesinsect

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    Integrating Primary Literature in a Lecture Course Using a Modified Version of the C.R.E.A.T.E. Approach
    Reforms in undergraduate science education place an increasing emphasis on teaching the skills of practicing scientists, such as reading and interpreting the primary research literature. Many...

    Keywords: primary literatureDiscussionModified JigsawPeer-based Learning

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    The Pipeline CURE: An Iterative Approach to Introduce All Students to Research Throughout a Biology Curriculum
    Participation in research provides personal and professional benefits for undergraduates. However, some students face institutional barriers that prevent their entry into research, particularly...

    Keywords: epigeneticsundergraduate researchmendelian inheritanceSelf-EfficacyCUREsnature of scienceResiliencecurriculum strategiesreprogramming

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    Investigating the Function of a Transport Protein: Where is ABCB6 Located in Human Cells?
    One of the challenges of teaching Cell Biology is helping students understand important research methods used to study cells.  The goal of understanding cell biology methods is especially...

    Keywords: ABC transporter familyDifferential centrifugationImmunoblottingImmunofluorescence assayProtein localizationPurifying organellesSDS-PAGE

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    Thinking deeply about quantitative analysis: Building a Biologist's Toolkit
    Vision and Change in Undergraduate Biology Education encouraged faculty to focus on core concepts and competencies in undergraduate curriculum. We created a sophomore-level course, Biologists'...

    Keywords: Vision and ChangeRRStudioquantitative literacystatistical analysisScientific communication

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