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    Nuclear and Cytoplasmic Viscosity
    This module introduces a modified Stokes-Einstein equation in the context of understanding the difference in viscosity between the nucleus and cytoplasm of cells

    Keywords: linear equationsCell StructureCell GrowthCytoplasmic Viscosity

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    Sperm Motility
    This module introduces equations related to oxygen diffusion in the context of understanding the relationship between oxygen needs and metabolism. It is intended for an introductory biology audience.

    Keywords: OpenStaxAnimal Physiologyparabolic equationssquare root

    797

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    Investigating Cell Signaling with Gene Expression Datasets
    Modern molecular biology is a data- and computationally-intensive field with few instructional resources for introducing undergraduate students to the requisite skills and techniques for analyzing...

    Keywords: genomicstranscriptionsignaling

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    Antigen presentation and cytotoxic T lymphocytes (CTLs): elucidating a common roadblock for students
    Active learning resource for pre-Nursing anatomy and physiology lecture explaining antigen presentation to CTLs and how the CTLs recognize and destroy the pathogen using Biointeractive animations...

    Keywords: Resources @ HHMI - BioInteractiveimmune systemAnatomy & PhysiologyCell communication

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    Why are Cells Small? Surface Area to Volume Ratio
    This module explores surface area to volume ratios in a cube and sphere in relation to cell size.

    Keywords: introductory biologygraphingRatiosOpenStaxqbccmanipulate equationsCellular and Molecular BiologyUse elementary functionsCreate graphsInterpret graphsRates and ProportionsSolving Equations and Inequalitiesinterpret tables

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    Infectious Chocolate Joy with a Side of Poissonian Statistics: An activity connecting life science students with subtle physics concepts
    Lesson on what it means for biological processes to be Poissonian, published in CourseSource

    Keywords: quantitative biologybioinformaticsmicrobiologyphysicsNIBLSEHIVCourseSourcemultiplicity of infectionPoisson Distribution

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    Using the Cell Engineer/Detective Approach to Explore Cell Structure and Function
    As instructors of introductory biology courses for majors and non-majors, we have struggled with teaching the concept of cell structure and function in an engaging way.  However, this is a...

    Keywords: cell functionCell StructureCellular diversityDynamic cellular functionOrganelle function

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    The Case of the Missing Strawberries: RFLP analysis
    While solving the fictional mystery of the missing strawberries, students are engaged in a guided-inquiry lesson featuring small-group and class discussions, hands-on activities, and laboratory...

    Keywords: process of scienceDNAforensicsgel electrophoresisMolecular genotypingRestriction endonucleaseRestriction enzymeRestriction fragment length polymorphismRFLP

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    Fatty Acid Induction of Lipid Droplets in Cancer Cells
    There is a growing need for the development and communication of cell culture-based laboratory activities specifically designed for undergraduate students. This multi-week laboratory activity...

    Keywords: Course based undergraduate researchCell ImagingLive Cell Staining

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    Targeting Misconceptions in the Central Dogma by Examining Viral Infection
    Understanding the central dogma and how changes in gene expression can impact cell function requires integration of several topics in molecular biology. Students often do not make the necessary...

    Keywords: datatranscriptionvirustranslationprotein functionmembrane transportPredictions

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    Cold blood and wet skin in hot and dry secondary forests. How do amphibian traits determine persistence in secondary forests?
    Students will synthesize information from biological and physiological traits of amphibians and characteristics of secondary forests in the tropics to form hypotheses about persistence of...

    Keywords: life historyconservation biologyphysiological ecologyamphibianland use changeEctothermsecondary foresttrait-based ecology

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    2003-Richard-Carson-Tracer kinetic modeling in PET
    The use of radiopharmaceuticals and the imaging of their biodistribution and kinetics with modern instrumentation are key components to successful developments in PET.

    Keywords: Metabolismtomographyradiopharmaceuticalspositron emission

    138

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    1971-Boyes-Scott-Jebson-Godman-Julian-Lidocaine in Man
    Plasma levels of lidocaine were measured in 5 normal male volunteers following both intravenous and oral administration of the drug.

    Keywords: pPharmacologypharmacokineticslidocaine

    119

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    COVID-19: Molecular Basis of Infection-ADAPTATION
    This case was written in Spring 2020 during the COVID-19 pandemic. It focuses on understanding the structure and interaction of the SARS-Cov-2 viral spike protein that facilitates infection in...

    Keywords: infectionvaccinemolecular visualization and analysisCOVID19PDBSARS-CoVMolecular Case Study

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    2018-Robert_Phair-Differential_equation_methods_for_simulation_of_GFP_kinetics_in_non–steady_state_experiments
    Here, we derive new tracer kinetic analytical methods for non–steady state biological systems by constructing mechanistic nonlinear differential equation models of the underlying cell biological...

    Keywords: protein quality controlkineticsCellssteady statechemical kineticsfluouresencephotoactivationinytracellular

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    COVID-19: Molecular Basis Infection Revisited One Year into the Pandemic
    This adaptation was written in Spring 2021 exactly one year after the original case and includes explorations of the emerging mutations within the spike protein

    Keywords: infectionvaccinemolecular visualization and analysisCOVID19PDBSARS-CoVMolecular Case Studyvariantsantibody

    954

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    Sizes, Scales and Specialization: Adapted to add scientific notation review
    This module explores how cell size and shape varies across cell types in the human body by having students calculate relative proportions of numbers in scientific notation. The adaptation has...

    Keywords: ExponentsRatiosScientific Notationcell typeqbccmanipulate equationsCellular and Molecular Biologyconverting unitschanging scales

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    2004-Ledzewicz-Schattler-Application of Control Theory in Modelling Cancer Chemotherapy
    In this paper we discuss how to incorporate more realistic medical aspects of chemotherapy which hitherto have been neglected in the models.

    Keywords: optimal controldrug resistancepharmacokineticspharmacodynamicschemotherapy

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    2015-Heiko_Enderling-Integrating experimental data to calibrate quantitative cancer models
    For quantitative cancer models to be meaningful and interpretable the number of unknown parameters must be kept minimal. We focus on a tumor hierarchy of cancer stem and progenitor non-stem cancer...

    Keywords: cancertumorfittingagent-based

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    Mitosis and Meiosis Resources
    New stop-motion ‘candymation’ videos of mitosis and meiosis, plus Instructor Guides and problem sets.

    Keywords: meiosislearningmitosisanimationscell division mechanismschromosomes

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