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    2008-Ribbing-EtAl-Mathematical models of diabetes progression
    Writing a good model for diabetes progression is difficult because the long time span of the disease makes experimental verification of modeling hypotheses extremely awkward. underlying the

    Keywords: physiologyclinical trialsdiabetesdiabetes progression

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    2008-Huangi-Lu-Modeling long-term longitudinal HIV dynamics with applications to an AIDS clinical study 
    To better understand the factors responsible for the virological failure, this paper develops the mechanism-based nonlinear differential equation models for characterizing long-term viral dynamics...

    Keywords: longitudinal dataAIDSantiretroviral drug therapyBayesian nonlinear mixed-effectstime-varying drug efficacyHIV dynamics

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    2007-Zenker-Rubin-Clermont-From inverse problems in mathematical physiology to quantitative differential diagnoses
    The improved capacity to acquire quantitative data in a clinical setting has generally failed to improve outcomes in acutely ill patients, suggesting a need for advances in computer-supported data...

    Keywords: physiologyinverse problem

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    Engaging Students in Pharmacogenetics: Patient Case Studies Using the PharmGKB Website
    Cytochrome P450 (CYP) enzymes are important regulators of drug efficacy and toxicity. Genetic variation in CYP isoforms can impact how well patients respond to medications or experience unwanted...

    Keywords: toxicologyPharmacologydrug metabolismpharmacodynamicspharmacogenetics

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    2007-Choisy-Guégan-Rohani-Mathematical Modeling of Infectious Diseases Dynamics
    After presenting general notions of mathematical modeling (Section 22.2) and the nature of epidemiological data available to the modeler (Section 22.3), we detail the very basic SIR epidemiological...

    Keywords: stochasticSIR modeldeterministicincubationinfectives

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    2003-Richard-Carson-Tracer kinetic modeling in PET
    The use of radiopharmaceuticals and the imaging of their biodistribution and kinetics with modern instrumentation are key components to successful developments in PET.

    Keywords: Metabolismtomographyradiopharmaceuticalspositron emission

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    2000-Idels-Wang-Harvesting Fisheries Management Strategies With Modified Effort Function
    This study concludes that a control parameter beta (the magnitude of the effect of the fish population size on the fishing effort function E), changes not only the rate at which the population goes...

    Keywords: sustainabilityfishFishingmanagementharvestfisherstrategyoverfishing

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    2017-Craig_Tracy-Lectures on Differential Equations
    These notes are for a one-quarter course in differential equations. The approach is to tie the study of differential equations to specific applications in physics with an emphasis on oscillatory...

    Keywords: physicsoscillation

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    1967-JG-Wagner-Computers in pharmacokinetics
    This is a seminal paper in pharmacokinetics in which the author introduces historic notions and approaches. As can be seen from the abstract there is a variety of material here.

    Keywords: kineticscomputerspharmacokinetics

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    1999-Peter_Deuflhard-Differential Equations in Technology and Medicine
    It deals with a variety of challenging real life problems selected from clinical cancer therapy, communication technology, polymer production, and pharmaceutical drug design.

    Keywords: cancerdesigntumordrugpolymertherapy

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    1971-Boyes-Scott-Jebson-Godman-Julian-Lidocaine in Man
    Plasma levels of lidocaine were measured in 5 normal male volunteers following both intravenous and oral administration of the drug.

    Keywords: pPharmacologypharmacokineticslidocaine

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    1969-Carl_Metzler-A mathematical model for the pharmacokinetics of LSD effect
    Contains data on performance scores vs. plasma levels of LSD in human tissues.

    Keywords: LSDtestingpharmacokineticsperformanceplasma level

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    1968-Wagner-Aghajanian-Bing-Correlation of performance test scores with tissue concentration of lysergic acid diethylamide
    This paper offers a two compartment model of lysergic acid diethylamide (LSD) in volunteer students and through parameter estimation models the amount of LSD in the tissue after its initial...

    Keywords: LSDcorrelation coefficientcompartment modellysergic acid diethylamideperformancetest scoretissue concentration

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    1976-JG-Wagner-Computers in pharmacokinetics
    This is a seminal paper in pharmacokinetics in which the author introduces historic notions and approaches. As can be seen from the abstract there is a variety of material here.

    Keywords: kineticscomputerparametersPharmacologydrugspharmacokinetics

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    2019-Radulescu-Lundgren-A_pharmacokinetic_model_of_lead_absorption_and_calcium_competitive_dynamics
    We build and analyze a compartmental model of lead pharmacokinetics, focused specifically on addressing neurotoxicity.

    Keywords: QUBES Leadership Teamparametersabsorptionbifurcationpharmacokineticscalciumcognitive decline

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    Modified Grassy Narrows and Muskrat Falls Dam: Hypothesis Testing and t-Tests
    Methylmercury contamination within fish populations is an important toxin that affect human, animal, and environmental health, serving as a carcinogen (cancer-causing agent) and endocrine-disruptor...

    Keywords: statisticsmathematicsbiostatisticsecologybiologygraphingp-valuest-testshypothesis testingin-class activityZoologymercury biogeochemistrybiostatistics - generalfish populationqbccEndocrine DisruptorsBiogeochemical cyclesInterpret graphsSolving Equations and InequalitiesConcepts in StatisticsElementary Hypothesis TestingMethylmercurydamsBioaccumulationtraditional dietsmercurymercury poisoningnative peopleindigenous populationCanadahydroelectricexplaining statisticsusing statisticsMake probability calculationsbiomagnification

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    How to Find a Gene: Retrieving Information From Gene Databases
    A strong understanding of distinct gene components and the ability to retrieve relevant information from gene databases are necessary to answer a diverse set of biological questions. However, often...

    Keywords: NCBItranscriptiontranslationGene StructureGene databasesEnsembl

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    Three Research-Based Quantitative Reasoning Modules for Introductory Organismal Biology Laboratories
    We have designed three laboratory modules for an introductory organismal biology course with an emphasis on quantitative reasoning and data analysis skills. Module 1 tests for dimorphism in...

    Keywords: allometryplantsAnatomytranspirationdimorphisminvertebrate biologyarthropodsplatyhelminths

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    Build Multiomic and Visualization Skills in Bioscience Lecture
    This resource promotes inclusive learning by using all free platforms to extend the central dogma to an applied experience. Genomics is focused on with literature reviews that are performed to...

    Keywords: geneticsBiochemistryBiology and Biochemistry EduationProtein StructureBioinformatics and GenomicsFunctional GenomicstranscriptomicsproteomicsRNAseqClinical genomicsprotein structure modelingInclusive teaching3D protein structure /function analysisinclusive classrooms3D protein structuresinclusivegene

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    A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation
    Mutations in genes can lead to a variety of phenotypes, including various human diseases. Students often understand that a particular mutation in a single gene causes a disease phenotype, but it is...

    Keywords: mutationProtein Structureethicscentral dogmahuman disease

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