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    Using Raw Sequence Data to Analyze Tumor Suppressor Mutations
    Learning to identify DNA sequence variants from raw sequencing data (electropherograms) is a basic molecular biology skill with applications to basic research and clinical practice. Yet learning to...

    Keywords: bioinformaticsmutationDNAgenomic visualizationparts of a geneclinical consequencesraw data

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    Breaking It Down: What Factors Control Microbial Decomposition Rates?
    Demonstrating and modeling changes in ecosystem processes in the laboratory classroom can be logistically difficult and expensive. This complexity often leaves little time for students to generate...

    Keywords: data analysishypothesis testingdata visualizationdata managementMicrobial RespirationDecompostionAbiotic ConditionsResults Communication

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    Central Dogma, Dictionaries, and Functions: Using Programming Concepts to Simulate Biological Processes
    Technologies like next-generation sequencing, proteomics, and high-throughput phenotyping have transformed the way we do biology. There is a continued need for scientists with computational skills...

    Keywords: computationpythonJupyter notebookFunctionscentral dogmaDictionaries

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    2017-Sim-EtAl-Optimal control of a coupled tanks system with model-reality differences
    In this paper, an efficient computational approach is proposed to optimize and control a coupled tanks system.

    Keywords: optimal controlflowtankscoupled tanks

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    2016-Banks-EtAl-Modeling Bumble Bee Population Dynamics with Delay Differential Equations
    To provide a tool for projecting and testing sensitivity of growth of populations under contrasting and combined pressures, we propose a delay differential equation model that describes...

    Keywords: population modelReproductionspline approximationsBombus terrestrisneonicotinoidsbumble bee

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    2006-Wilensky-Reisman-Thinking Like a Wolf a Sheep or a Firefly
    We describe a computation-based approach that enables students to investigate the connections between different biological levels using agent-based, embodied modeling tools.

    Keywords: simulationNetLogopredator-preyagent-basedwolffox

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    2009-Eriksson- Estep-Hansho-Johnson-Computational Differential Equations
    Differential Equations and Advanced Computational Differential Equations, presents a unified approach to computational mathematical modeling using differential equations based on a principle of a...

    Keywords: Galerkin

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    2012-Brian_Ingalls-Mathematical Modelling in Systems Biology An Introduction
    This is a comprehensive text with much biology background to motivate the mathematical modeling, exercises and answers, and many rich examples.

    Keywords: spatialsensitivity analysisgene regulatory networksstochasticbifurcationmetabolic networkselectrophysiologytransductionrate lawsbiochemical reactions

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    Learning R for Biologists: A Mini Course Grab-Bag for Instructors
    As biology becomes more data driven, teaching students data literacy skills has become central to biology curriculum. Despite a wealth of online resources that teach researchers how to use R, there...

    Keywords: Rdata analysisRStudio

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    2014-William_Trench-Elementary_Differential_Equations-Books_and_Monographs
    This is the most widely cited and referenced free online text for differential equations and is very complete. These two books are exactly what they say they are.

    Keywords: differential equationstextbook

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    Making Change Sustainable: Network for Integrating Bioinformatics into Life Sciences Education (NIBLSE) Meeting Review
    The purpose of the meeting described in this review was to decide how best to ensure the sustainability of the Network for Integrating Bioinformatics into Life Science Education (NIBLSE; pronounced...

    Keywords: meetingsustainabilityfmnNIBLSEincubator

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    2-005-LinearizeItAll-TechniqueNarrative
    Linear approximations are often used to simplify nonlinear ordinary differential equations (ODEs) for ease in analysis. The resulting linear approximation produces an ODE where closed form...

    Keywords: computationerrorTorricelli's Lawdata fittinglinear approximation

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    1-030-RandomPerturbation-TechniqueNarrative
    After a brief historical view of this problem, we will demonstrate the derivation of first order linear differential equations with random perturbations.

    Keywords: random perturbationBrownian motionLangevin equationRiemann-Steiltjes integralWiener processIto's calculus

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    1-065-AlgalBlooms-ModelingScenario
    This modeling scenario investigates the massive algal blooms that struck Lake Chapala, Mexico, starting in 1994.

    Keywords: direction fieldstool:dfieldalgaeharmful algae bloomspopulationcompartmentLake Chapala

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    1-081-TumorGrowth-ModelingScenario
    Students will transform, solve, and interpret a tumor growth scenario using non-linear differential equation models. Two population growth models (Gompertz and logistic) are applied to model tumor...

    Keywords: logisticpopulationtumorGompertz

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    6-026-IsleRoyaleModeling-ModelingScenario
    The primary aim of this project is to draw a connection between differential equations and vector calculus, using population ecology modeling as a vehicle.

    Keywords: ecologyoptimizationpredator-preypopulationvector calculusLagrange multipliersleast squaresIslel Royale

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    Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging
    Organelle structure has been studied and visualized for decades; however, publicly available databases that use improved high-throughput microscopy of gene-edited cell lines have recently...

    Keywords: modelingcase studymicroscopystructureOrganellesHigh-throughput (HT)Endoplasmic Reticulum (ER)Fluorescent microscopyHuman Cell Biology

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    Using Bioinformatics and Molecular Visualization to Develop Student Hypotheses in a Malate Dehydrogenase Oriented CURE
    Developing student creativity and ability to develop a testable hypothesis represents a significant challenge in most laboratory courses. This lesson demonstrates how students use facets of...

    Keywords: bioinformaticsNoncovalent InteractionsEnzyme CatalysisProtein Structure/function

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    A 360˚ View of COVID-19
    In March 2020, institutions underwent a massive transition to distance learning as a result of the COVID-19 pandemic. With so little time to devise new materials to maximize learning in the new...

    Keywords: geneticsImmunologyBiochemistrybioinformaticsmolecular evolutionpublic healthvirusCOVID19

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    Moths and Frogs and E. coli, Oh My!: Agent-based Modeling of Evolutionary Systems
    In evolution classrooms, introducing and reinforcing the idea of genetic drift and random selection can be challenging, as can be reinforcing appropriate mental models of evolution. Agent-based...

    Keywords: modelingEvolutionecologyagent-based modelingGenetic Driftenvironmental scienceNatural Selectioncompetitive coevolutionsimulation modelingevolutionary reasoning

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