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    Online Adaptation of the Cell Engineer/Detective Lesson
    One of the most fundamental themes of biology is the relationship between structure and function, which is particularly evident when it comes to cells; however, the traditional cartoon depictions...

    Keywords: cell functionCell StructureOrganelles

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    A "Box of Lessons" for Exploring Biomolecular Structure and Function
    Biomolecular structure and function is emphasized as a core concept in a variety of community determined educational standards for biology and chemistry. Most curricula introduce students to the...

    Keywords: bioinformaticsproteinsRNADNAmolecular visualizationbiomolecular structurebiomolecular visualizationProtein Data BankPDBMolecular CaseNet FMN

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    The Human Microbiome Biodiversity in Health and Disease
    The students will analyze the human gut and vaginal microbiomes in healthy and diseased states using diversity of bacteria as determined by 16SrRNA sequence.
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    Drugging SARS-CoV-2
    This case study leads students through the process of proposing a drug for a novel protein. The Mpro protease of SARS-CoV-2 is explored in detail within the PDB. Aligns with first semester...

    Keywords: viruscoronavirusPDBSARS-CoV-2proteasedrug design

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    Introduction to Genome Annotation
    This exercise is an adaptation of the Annotation Lesson by Rosenwald et al. It introduces the use of bioinformatics tools to extract information from genome databases. It is a basic lesson on...

    Keywords: microbiologyGenome annotationBioinformatics EducationBioinformatics and Genomics

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    The p53 Gene and Cancer
    This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer.

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymolecular biologymacromoleculesGenetic disease

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    Mentoring Undergraduate Research Projects in Mathematical Biology
    Part of the 2015 SMB Minisymposium: Topics in Biomathematics Education

    Keywords: epidemiologymentoringcurriculumundergraduate researchGene regulatory networkpest management

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    Cross-Scale Interactions (Project EDDIE)
    Students explore new modeling and computing tools while learning fundamental concepts about how lake phytoplankton blooms occur through cross-scale interactions.

    Keywords: modelingProject EDDIE

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    An introduction to population matrix models: a swirl lesson
    Students will learn how to set up a population matrix model in R and use it for demographic analysis of a population, including projecting population growth, determining lambda and the stable age...

    Keywords: population dynamicsRpopulation growthonlinedemographypopulation projection modelquantitative biologypopulation modelmatrix modelspopulation ecologyage structurepopulation biologypopulation modelingSwirlDemographic processespopulationLeslie matrix

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    The Happy Blue Baby Hemoglobin
    This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved.

    Keywords: mutationHemoglobinmolecular visualization and analysisPDBMolecular Case Study

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    Using Open-Source Bioinformatics and Visualization Tools to Explore the Structure and Function of SARS-CoV-2 Spike Protein
    The relationship between protein structure and function is a foundational concept in undergraduate biochemistry. We find this theme is best presented with assignments that encourage exploration and...

    Keywords: bioinformaticsmolecular modelingCOVID19protein structure and functionUCSF ChimeraSARS-CoV-2 spike proteinACE2 receptor

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    Sustainability Metrics (Project EDDIE)
    In this module, students will use an analytical framework with publicly available data to formulate questions, analyze data, and report metrics of sustainability.
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    Plate Tectonics: GPS Data, Boundary Zones, and Earthquake Hazards (Project EDDIE)
    Students work with high precision GPS data to explore how motion near a plate boundary is distributed over a larger region and hypothesize the area over which boundary-related earthquake hazards...
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    Sustainability Metrics (Project EDDIE)
    In this module, students will use an analytical framework with publicly available data to formulate questions, analyze data, and report metrics of sustainability.
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    Build-a-Phage Lab Manual
    This is a lab manual for phage genome synthesis that includes both Building Block synthesis and Semi-synthetic assembly.
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    (Online) Figure of the Week: Skills for Interpreting Comparative Genomics Figures
    Students use their number sense to make observations and explain or guess at patterns shown, discussing in a weekly online Q&A forum.

    Keywords: graphsonline learningmath anxietyonline forummath attitudesResources @ BIOMAAPInterpreting Graphsdiscussion forumComparative genomics

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    Environmental Pollution & Public Health (Project EDDIE) used in an introductory Environmental Challenges course
    Environmental health is a field of study within public health that is concerned with human-environment interactions, and specifically, how the environment influences public well-being. In this...

    Keywords: public healthProject EDDIEpollution

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    Climate Change Module (Project EDDIE) for Introductory Statistics
    Students practice and deepen their understanding of bivariate numerical data analysis (correlation, linear regression, etc.) through working with data related to climate change. Adapted from a...

    Keywords: statistics

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    Molecular Basis of Sickle Cell Disease
    This multi part case on hemoglobin structure as it relates to oxygen binding and sickle cell disease focuses on utilizing bioinformatics and molecular visualization tools to learn about the sickle...

    Keywords: Hemoglobinmolecular visualization and analysisintroductory bioinformaticssickle cell diseasePDBMolecular Case Studyoxygen bindingmyoglobinmolecular literacy3D protein structuresstructural representations

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    Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course
    A foundational knowledge of the relationship between structure and function is critical to understanding how enzymes work. The seemingly invisible nature of these molecular interactions makes it...

    Keywords: structure-functionEnzymeallosteric regulationcompetitive inhibitionfeedback inhibitionnoncompetitive inhibitionproductsubstrate

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