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    A Short Laboratory Module to Help Infuse Metacognition during an Introductory Course-based Research Experience
    A core competency identified in Vision and Change for undergraduate biology students is the Ability to Apply the Process of Science. Here, we describe a three-week laboratory module for students in...

    Keywords: metacognitiongene expressionScientific ProcessExperimenal DesignHypothesis Generationmodel organisms

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    Discovering Prokaryotic Gene Regulation by Building and Investigating a Computational Model of the lac Operon
    The ability to construct and reason through a biological system is an important skill to develop in science education. This level of understanding forces students to recognize the interrelatedness...

    Keywords: prokaryotesgene regulationLac Operoninducible operon

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    Sequence Similarity: An inquiry based and "under the hood" approach for incorporating molecular sequence alignment in introductory undergraduate biology courses
    Introductory bioinformatics exercises often walk students through the use of computational tools, but often provide little understanding of what a computational tool does "under the...

    Keywords: BLASTmultiple sequence alignmentsequence similarityphylogramZika virusAlgorithmScoring Matrix

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    Using a Sequential Interpretation of Data in Envelopes (SIDE) approach to identify a mystery TRP channel
    This lesson sought to engage students in data interpretation and to encourage critical thinking about neurophysiology in the context of temperature sensation. A family of receptors called Transient...

    Keywords: Cell communicationChannel specificity and activationLimitations of tools of Cell BiologyNeuronal Signaling

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    Active Learning: Developing Self-Directed Learners Through Strong Intellectual Engagement
    When they were students, many current science instructors learned through traditional lectures. This mode of passive knowledge transmission has been shown to be less effective for student learning...

    Keywords: active learningmetacognitionconstructivism

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    Linking Genotype to Phenotype: The Effect of a Mutation in Gibberellic Acid Production on Plant Germination
    Basic concepts in genetics and plant development are often taught in lecture courses without a lab component. This approach provides students with the content knowledge, but fails to make...

    Keywords: geneticsdevelopmentmutationgerminationplantmodel organismGenotype/PhenotypeHormoneSeed

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    A new approach to course-based research using a hermit crab-hydrozoan symbiosis
    There are few feasible models for marine-focused inquiry laboratory activities, a notable shortcoming for instructors seeking to engage their students in meaningful, course-based research...

    Keywords: behaviorparasitismSymbiosismutualismcommensalism

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    Knowing your own: A classroom case study using the scientific method to investigate how birds learn to recognize their offspring
    Understanding the scientific method provides students with a necessary foundation for careers in science-related fields. Moreover, students can apply scientific inquiry skills in many aspects of...

    Keywords: scientific methodNatural Selectionbrood parasitism

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    The Case of the Missing Strawberries: RFLP analysis
    While solving the fictional mystery of the missing strawberries, students are engaged in a guided-inquiry lesson featuring small-group and class discussions, hands-on activities, and laboratory...

    Keywords: process of scienceDNAforensicsgel electrophoresisMolecular genotypingRestriction endonucleaseRestriction enzymeRestriction fragment length polymorphismRFLP

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    Defining Life: Exploring Creativity, Scientific Discovery, and Biology Core Concepts in a Disciplinary First-Year Seminar
    This unit, Defining Life, engages students in thinking like scientists, applying creativity to science, and learning biology core concepts as they explore the defining characteristics of life. This...

    Keywords: Evolutionbiologycellprocess of science

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    The ACTN3 Polymorphism: Applications in Genetics and Physiology Teaching Laboratories
    Inquiry-based undergraduate laboratories provide the opportunity to engage students in a research experience that improves scientific thinking, but such activities can be difficult to develop and...

    Keywords: protein structure and functionhuman genetic variationmuscle physiology

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    Learning R for Biologists: A Mini Course Grab-Bag for Instructors
    As biology becomes more data driven, teaching students data literacy skills has become central to biology curriculum. Despite a wealth of online resources that teach researchers how to use R, there...

    Keywords: Rdata analysisRStudio

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    Application of a Bacterial Experimental Evolution System to Visualize and Teach Evolution in Action: A Course-Based Undergraduate Research Experience
    Concepts of evolution are typically taught through examples of extremely long timescales, which do not always resonate broadly. Here, we describe a course-based undergraduate research experience...

    Keywords: EvolutionmutationcompetitionNatural Selectionregulationstructure and functionreproductive fitnessgenotype to phenotypehomologs

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    A Laboratory Module That Explores RNA Interference and Codon Optimization Through Fluorescence Microscopy Using Caenorhabditis elegans
    Scientific research experiences are beneficial to students allowing them to gain laboratory and problem-solving skills, as well as foundational research skills in a team-based setting. We designed...

    Keywords: microscopyC. elegansquantitative analysisinquiry-based learninggene expressionRNA interferenceCodon UsageLaboratory Module

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    Design Your Own Flow Cytometry Experiment: A Four-Week Inquiry Laboratory
    Due to its importance to the field, flow cytometry should be one of the hallmark methods a student learns in the lab portion of an undergraduate immunology course. Flow cytometry is a classic lab...

    Keywords: Immunologyexperimental designFlow cytometryMice

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    Fly Exercise: A Simple Experiment to Test the Physiological Effects of Exercise on a Model Organism
    Model organisms are commonly used to study and experimentally explore biological processes in ways that are technically or ethically not possible in humans. For this reason, model organisms are an...

    Keywords: exerciseenzyme kineticsmetabolite concentrationmodel speciesphysical activity

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    Sorry to Eat and Run: A Lesson Plan for Testing Trade-off in Squirrel Behavior Using Giving Up Densities (GUDs)
    All animals need to find and compete for food, shelter, and mates in order to survive and reproduce. They also need to avoid being eaten by predators. Optimal foraging theory provides a framework...

    Keywords: ecologyanimal behaviorAnimal form and functionAnimal nutritionSquirrel-Net

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    Using Musical Instruments to Model Negative Feedback in the Hypothalamo-Pituitary-Target Gland Axes
    Homeostasis and negative feedback are crucial, yet difficult, concepts for undergraduates, particularly in the context of the hypothalamo-pituitary axes. This interactive activity was designed to...

    Keywords: cell-cell communicationhomeostasisnegative feedback

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    Using Student Perceptions and Cooperative Learning to Unpack Primary Literature on Global Change
    This case describes a three-part assignment in which students discuss key processes that regulate the stability and resilience of the Earth system and our increased risk of generating large-scale...

    Keywords: global changeAnthropoceneEarth-systemplanetary boundary conceptthresholds

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    Using Immunocytochemistry and Fluorescence Microscopy Imaging to Explore the Mechanism of Action of Anti-Cancer Drugs on the Cell Cycle
    Understanding and visualizing the cell cycle and mitosis is an essential concept of cell biology. This multi-week lab module has students investigate the mechanism of action of anti-cancer drugs...

    Keywords: fluorescence microscopymitosisCell StructureCell ImagingImmunocytochemistryQuantitative microscopySTEM skills

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