You are here: Home / Resources / Browse Resources

Open. Adaptable. Free.

Resources created by our members and partners.

The QUBES platform hosts hundreds of teaching materials, reference materials, and cloud-based software free to use and adapt using open Creative Commons licenses.

Text Search:
Applied Filters
    2005-Minna_Wedenberg-Pharmacokinetic modeling of gastric emptying
    The development of new drug substances is a complex, time consuming and expensive process. Reducing the time for drug development and avoiding late termination of candidate drugs are important...

    Keywords: paracetamolpharmacokineticsstomachsmall intestinesulfapyridine

    118

    views

    37

    downloads

    0

    comments

    0

    adaptations

    2017-ASHP-Intro to Pharmacokinetics and Pharmacodynamics
    This is the introductory Lesson 1 in an online set of materials to introduce Pharmacokinetics and Pharmacodynamics.

    Keywords: absorptioncompartmentbloodstreamplasmapharmacokineticsdrugpharmacodynamics

    116

    views

    44

    downloads

    0

    comments

    0

    adaptations

    1-131-CaffeineElimination-ModelingScenario
    We model the concentration of caffeine eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the...

    Keywords: caffeineeliminationpharmacokineticsdrug

    204

    views

    74

    downloads

    0

    comments

    0

    adaptations

    1999-Peter_Deuflhard-Differential Equations in Technology and Medicine
    It deals with a variety of challenging real life problems selected from clinical cancer therapy, communication technology, polymer production, and pharmaceutical drug design.

    Keywords: cancerdesigntumordrugpolymertherapy

    134

    views

    39

    downloads

    0

    comments

    0

    adaptations

    1-130-AspirinAbsorption-ModelingScenario
    We model the amount of aspirin absorbed by the human body at a constant rate. This is a ``zero-order reaction'' in the language of pharmacokinetics -- the study of how drugs move in the body.

    Keywords: pharmacokineticsdrugaspirin

    235

    views

    165

    downloads

    0

    comments

    0

    adaptations

    1-132-DigoxinElimination-ModelingScenario
    We model the concentration of digoxin eliminated from the human body at a rate proportional to the concentration. This is a ``first-order reaction'' in the language of pharmacokinetics -- the study...

    Keywords: nullclinespharmacokineticsdigoxindrug eliminationtwo compartment

    306

    views

    474

    downloads

    0

    comments

    0

    adaptations

    2015-Valerie_Billard-Pharmacokinetic-pharmacodynamic relationship of anesthetic drugs - from modeling to clinical use
    The purpose of this short review is to describe the basis of pharmacokinetics and modeling, the concentration-effects relationship, and drug interactions modeling to offer to anesthesiologists and...

    Keywords: anesthesiapharmacokineticspharmacodynamicanesthetic

    176

    views

    53

    downloads

    0

    comments

    0

    adaptations

    2002-Chai-Optimal initial angle to fire a projectile
    Assume a projectile is fired without air resistance and lands at a height y above its initial vertical position. What is the optimal initial angle of firing to maximize the horizontal distance...

    Keywords: optimizationprojectile motionlaunch angle

    114

    views

    39

    downloads

    0

    comments

    0

    adaptations

    Mutation and Selection: An Exploration of Antibiotic Resistance in Serratia Marcescens
    This laboratory module gives students hands-on experience with mutation and selection in bacteria.

    Keywords: moduleinquiry labsmutationartificial selectionbacteriain-class activityHandoutlab protocolResources @ QUBES - Teaching & Referenceantibiotic-resistance

    1239

    views

    232

    downloads

    0

    comments

    0

    adaptations

    2011-Nguyen-Shi-Modeling the absorption circulation and metabolism of tirapazamine
    This apparently is a student project and it develops the kinetic model, uses Matlab for numerical solution, analytic solution and numerical solution.

    Keywords: absorptionMichaelis-MentenMetabolismdrug metabolismcirculation

    128

    views

    39

    downloads

    0

    comments

    0

    adaptations

    Pharmacokinetics
    This Excel module explores how drugs are processed and absorbed in the human body.

    Keywords: drug metabolismpharmacokinetics

    37

    views

    10

    downloads

    0

    comments

    0

    adaptations

    Understanding the Importance of Microtubules in Normal Cell Division: Chemotherapy Connection
    In introductory courses, students learn about microtubules as important structures but may not engage in a hands-on experience to localize microtubules themselves or to learn about their connection...

    Keywords: cancerCell DivisionimmunofluorescenceMicrotubulesAntibodies

    1080

    views

    97

    downloads

    0

    comments

    0

    adaptations

    2018-David_Bourne-Pharmacokinetics – Source Material
    This is a rich source of pharmacokinetics modeling activities and data. These are syllabus notes with homework assignments listed.

    Keywords: boluspharmacokineticspharmacodynamicdrug distribution

    232

    views

    82

    downloads

    0

    comments

    0

    adaptations

    1971-Carl_Metzler-Usefulness Of Two Compartment Open Model In Pharmacokinetics
    Compartment models are widely used in pharmaceutical research to quantitate the kinetics of absorption, distribution, metabolism and excretion of a drug. In this article two applications of the two...

    Keywords: LSDcompartmentpharmacokinetics

    160

    views

    82

    downloads

    0

    comments

    0

    adaptations

    1957-Axelrod_ Brady_Witkop_Evarts-The Distribution and Metabolism of Lysergic Acid Diethylamide
    The development of a specific and sensitive method for the estimation of LSD in biological materials has enabled us to study the tissue distribution, excretion, rate of biotransformation, and...

    Keywords: mathematical modeldataLSDMetabolismbloodstreamlysergic acid diethylamidedistribution

    184

    views

    78

    downloads

    0

    comments

    0

    adaptations

    1-138-InnerEarDrugDelivery-ModelingScenario
    Students examine local drug delivery to the cochlea. The delivery system is modeled as a liquid mixing problem. Students formulate the differential equation, and solve the equation using separation...

    Keywords: concentrationdrug deliveryinner earcochleahearing loss

    369

    views

    255

    downloads

    0

    comments

    0

    adaptations

    1-016-DogDrugs-ModelingScenario
    We offer a problem to determine the necessary drug administration in order to keep a dog sedated with specific information on half-life for an exponentially decaying presence of the drug in the body.

    Keywords: wild_dogsdrug discoveryhalf-lifepentobarbital sodiumanesthesia

    340

    views

    188

    downloads

    0

    comments

    0

    adaptations

    Drugging SARS-CoV-2
    This case study leads students through the process of proposing a drug for a novel protein. The Mpro protease of SARS-CoV-2 is explored in detail within the PDB. Aligns with first semester...

    Keywords: viruscoronavirusPDBSARS-CoV-2proteasedrug design

    1314

    views

    373

    downloads

    0

    comments

    0

    adaptations

    2017-CW_Groetsch-Hammer and Feather - Some Calculus of Mass and Fall Time
    Does a heavy object fall faster than a lighter one? In 1971 NASA astronaut Dave Scott, Commander of the Apollo 15 lunar mission, used a hammer and a falcon feather on the surface of the moon to...

    Keywords: gravityfree falllinear resistancequadratic resistancehammerfeatherMoon resistanceGalileo

    144

    views

    56

    downloads

    0

    comments

    0

    adaptations

    3-043-BallisticModeling-SpongeDart-ModelingScenario
    The goal of this project is for students to develop, analyze, and compare three different models for the flight of a sponge dart moving under the influences of gravity and air resistance.

    Keywords: projectile motionair resistanceballisticsdimensional analysisNewtonian mechanicssponge dartNerf gunNerf dartBuckingham's Theorem

    587

    views

    696

    downloads

    0

    comments

    0

    adaptations

    Close

    Home

    Search