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    2015-Valerie_Billard-Pharmacokinetic-pharmacodynamic relationship of anesthetic drugs - from modeling to clinical use
    The purpose of this short review is to describe the basis of pharmacokinetics and modeling, the concentration-effects relationship, and drug interactions modeling to offer to anesthesiologists and...

    Keywords: anesthesiapharmacokineticspharmacodynamicanesthetic

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    An evolution curriculum designed around understanding the rise and spread of drug-resistant pathogens
    Poster on teaching concepts in evolution and data science skills in an upper level Biology elective at Spelman College presented at the 2018 QUBES/BioQUEST Summer Workshop

    Keywords: EvolutionRdata sciencedrug resistanceSummer Workshop 2018

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    Taking the Hassle out of Hasselbalch
    Mention pH in a classroom and you can almost see the inner yawn on the faces of your students. The definition may even roll easily from their lips. However, despite multiple exposures to the...

    Keywords: pHdrug uptakeHenderson-Hasslbalch equationmedical applicationspKa

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    2011-Nguyen-Shi-Modeling the absorption circulation and metabolism of tirapazamine
    This apparently is a student project and it develops the kinetic model, uses Matlab for numerical solution, analytic solution and numerical solution.

    Keywords: absorptionMichaelis-MentenMetabolismdrug metabolismcirculation

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    2008-Luis_San_Andrés-Dynamic Response of Second Order Mechanical Systems with Viscous Response Forces
    Walk through the cases in context of second order linear constant coefficient differential equation with driving function

    Keywords: driving functionviscousmechanical system

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    2018-David_Bourne-Pharmacokinetics – Source Material
    This is a rich source of pharmacokinetics modeling activities and data. These are syllabus notes with homework assignments listed.

    Keywords: boluspharmacokineticspharmacodynamicdrug distribution

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    2004-Ledzewicz-Schattler-Application of Control Theory in Modelling Cancer Chemotherapy
    In this paper we discuss how to incorporate more realistic medical aspects of chemotherapy which hitherto have been neglected in the models.

    Keywords: optimal controldrug resistancepharmacokineticspharmacodynamicschemotherapy

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    1971-Carl_Metzler-Usefulness Of Two Compartment Open Model In Pharmacokinetics
    Compartment models are widely used in pharmaceutical research to quantitate the kinetics of absorption, distribution, metabolism and excretion of a drug. In this article two applications of the two...

    Keywords: LSDcompartmentpharmacokinetics

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    1957-Axelrod_ Brady_Witkop_Evarts-The Distribution and Metabolism of Lysergic Acid Diethylamide
    The development of a specific and sensitive method for the estimation of LSD in biological materials has enabled us to study the tissue distribution, excretion, rate of biotransformation, and...

    Keywords: mathematical modeldataLSDMetabolismbloodstreamlysergic acid diethylamidedistribution

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    1-138-InnerEarDrugDelivery-ModelingScenario
    Students examine local drug delivery to the cochlea. The delivery system is modeled as a liquid mixing problem. Students formulate the differential equation, and solve the equation using separation...

    Keywords: concentrationdrug deliveryinner earcochleahearing loss

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    1-016-DogDrugs-ModelingScenario
    We offer a problem to determine the necessary drug administration in order to keep a dog sedated with specific information on half-life for an exponentially decaying presence of the drug in the body.

    Keywords: wild_dogsdrug discoveryhalf-lifepentobarbital sodiumanesthesia

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    Drugging SARS-CoV-2
    This case study leads students through the process of proposing a drug for a novel protein. The Mpro protease of SARS-CoV-2 is explored in detail within the PDB. Aligns with first semester...

    Keywords: viruscoronavirusPDBSARS-CoV-2proteasedrug design

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    A 360˚ View of COVID-19
    In March 2020, institutions underwent a massive transition to distance learning as a result of the COVID-19 pandemic. With so little time to devise new materials to maximize learning in the new...

    Keywords: geneticsImmunologyBiochemistrybioinformaticsmolecular evolutionpublic healthvirusCOVID19

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    Does Organelle Shape Matter?: Exploring Patterns in Cell Shape and Structure with High-Throughput (HT) Imaging
    Organelle structure has been studied and visualized for decades; however, publicly available databases that use improved high-throughput microscopy of gene-edited cell lines have recently...

    Keywords: modelingcase studymicroscopystructureOrganellesHigh-throughput (HT)Endoplasmic Reticulum (ER)Fluorescent microscopyHuman Cell Biology

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    2014-Niemann-Miklos-Simple Method for Estimation of Parameters in First Order Systems
    A simple method for estimation of parameters in first order systems with time delays is presented in this paper.

    Keywords: delaytime delystep response

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    2014-John_Cimbala-Dynamic System Response
    In this learning module, we discuss the dynamic system response of sensors and their associated electronic circuits.

    Keywords: sensor networksoscillationssystem responseelectronic circuit

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    Type I Functional Response
    This module introduces the type I functional response in the context of understanding the relationship between an individual's rate of consumption and food density. It is intended for an...

    Keywords: ecologylinear equationsfood density

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    1999-Khorasheh-Ahmadi-Gerayeli-Application of Direct Search Optimization for Pharmacokinetic Parameter Estimation
    For simple pharmacokinetic compartmental models, analytical solution to the governing differential equations provide a mean to evaluate the associated rate constants. Such methods, however, can not...

    Keywords: sum of square errorsleast squarespharmacokineticslineteicscompartmental modelsdirect search

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    1971-Boyes-Scott-Jebson-Godman-Julian-Lidocaine in Man
    Plasma levels of lidocaine were measured in 5 normal male volunteers following both intravenous and oral administration of the drug.

    Keywords: pPharmacologypharmacokineticslidocaine

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    3-105-FrequencyResponse-ModelingScenario
    We describe the frequency response to a second order differential equation with a driving function as the maximum steady state solution amplitude and perform some analyses in this regard.

    Keywords: transient dynamicscircuitspring massdriverfrequency responseamplitudesteady state

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