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    2017-Fred_Adler-Mathematically Modeling Asthma
    Our Asthma models have examined how a viral infection can tip the immune system into a different state, with the potential to predispose an individual to future asthma

    Keywords: infectionasthmaimmune responserhinovirus

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    2016-Barbarossa-Kuttler-Mathematical Modeling of Bacteria Communication in Continuous Cultures
    This paper presents a simple system of delay differential equations (DDEs) for quorum sensing of Pseudomonas putida with one positive feedback plus one (delayed) negative feedback mechanism.

    Keywords: gene regulatory networkschemostatbifurcationNumerical Simulationquorum sensing

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    2012-Transtrum-Qiu-Optimal experiment selection for parameter estimation in biological differential equation models
    We explore the question to what extent parameters can be efficiently estimated by appropriate experimental selection.

    Keywords: experimental designsystems biologyAssociation & Data Fittingreaction ratesdecay rates

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    2012-Shargel-Yu-AccessPharmacy-Applied Biopharmaceutics and Pharmacokinetics
    Step by step formation of drug absorption models is shown with many good graphics of system and plots. Solutions are offered but no solution methods are shown.

    Keywords: Michaelis-MentenEnzymesubstratecompartmentpharmacokineticsrate constanturinary dataabsorption rate

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    2008-Duran-Caginalp-Parameter optimization for differential equations in asset price forecasting
    The optimization procedure is used in conjunction with daily market prices (MPs) and net asset values to determine the parameters for which the AFDE yield the best fit for the previous n days.

    Keywords: financeinverse problemnumerical nonlinear optimizationasset flowfinancial market dynamicsmarket return prediction algorithm

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    2008-Brewer-EtAl-Fitting ordinary differential equations to short time course data
    In this paper, we present a survey of existing algorithms and describe the main approaches. We also introduce and evaluate a new efficient technique for estimating ODEs linear in parameters...

    Keywords: time seriesEvaluation SPLINEgeneleast squaresbifurcation

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    Engaging Students in Pharmacogenetics: Patient Case Studies Using the PharmGKB Website
    Cytochrome P450 (CYP) enzymes are important regulators of drug efficacy and toxicity. Genetic variation in CYP isoforms can impact how well patients respond to medications or experience unwanted...

    Keywords: toxicologyPharmacologydrug metabolismpharmacodynamicspharmacogenetics

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    2006-Han-EtAl-Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology
    Physiologically-based pharmacokinetic (PBPK) models have been used to describe the distribution and elimination characteristics of intravenous ethanol administration.

    Keywords: liverwortsintraveneouspharmacokineticsethanolethanol infustionpharmacodynamictissue model

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    Discovery and Invention: A Reflection on Representation in Science
    Despite increased awareness of the lack of equity and inclusion in the STEMM classroom, lessons on DEI topics are treated as separate to the scientific curriculum being taught. Rarely are...

    Keywords: EquityDiversity and Inclusionantiracism

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    2005-Saifullah-Mathematical Modeling With Differential Equations
    This article aims to provide the students some basic modeling skills, which will have applications to a wide variety of problems.

    Keywords: species interactionsword equationinteractive software

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    2005-P_Howard-Modeling with ODE
    In these notes we consider three critical aspects in the theory of ordinary differential equations: developing models of physical phenomena, mathematically well-posed, solving ODE numerically .

    Keywords: Fluid Mechanicscompartmentpopulationsvariational methodsHamiltonian mechanics

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    2005-Minna_Wedenberg-Pharmacokinetic modeling of gastric emptying
    The development of new drug substances is a complex, time consuming and expensive process. Reducing the time for drug development and avoiding late termination of candidate drugs are important...

    Keywords: paracetamolpharmacokineticsstomachsmall intestinesulfapyridine

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    2003-Richard-Carson-Tracer kinetic modeling in PET
    The use of radiopharmaceuticals and the imaging of their biodistribution and kinetics with modern instrumentation are key components to successful developments in PET.

    Keywords: Metabolismtomographyradiopharmaceuticalspositron emission

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    2003-Rasmussen-Keynes-Lines of Eigenvectors and Solutions to Systems of Linear Differential Equations
    The purpose of this paper is to describe an instructional sequence where students invent a method for locating lines of eigenvectors and corresponding solutions to systems of two first order linear...

    Keywords: instructional designeigenvalueseigenvalue analysis

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    2000-Erdman-Morelock-A Study of Kinetics The Estimation and Simulation of Systems of First-Order Differential Equations
    This paper introduces new and old features of the SAS System for the estimation and simulation of systems of first-order differential equations with emphasis on examples in kinetics.

    Keywords: kineticsSAScompartmentpharmacokinetics

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    2000-deOlivera-Delfino-Costa-Leite-Pinhole Water Flow From Cylindrical Bottles
    The water flowing from the first bottle feeds the second one located below it. The same concepts of mass and energy conservation now lead to a non-trivial differential equation for the lowest...

    Keywords: Torricelli's LawConservation of EnergytConservation of MassBernoulli’s Theorem

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    1999-McCartney-Carey-Modelling Traffic Flow Solving and Interpreting Differential Equations 
    A simple mathematical model for how traffic flows along a road is introduced.

    Keywords: traffictraffic flow

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    2016-Langtangen-Pedersen - Scaling of Differential Equations
    Nowadays, the greatest practical benefit of scaling is related to running numerical simulations, since scaling greatly simplifies the choice of values for the input data and makes the simulations...

    Keywords: scalingdimensionlesscontinuum mechanics

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    2012-Brian_Ingalls-Mathematical Modelling in Systems Biology An Introduction
    This is a comprehensive text with much biology background to motivate the mathematical modeling, exercises and answers, and many rich examples.

    Keywords: spatialsensitivity analysisgene regulatory networksstochasticbifurcationmetabolic networkselectrophysiologytransductionrate lawsbiochemical reactions

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    Integrating the modeling of biogeochemical cycles and energy flow
    This in-class activity challenges students to create and then integrate models of how carbon, nitrogen, water and energy all move within an ecosystem. Using 15 provided standard pools, they work...

    Keywords: modelingecologyintegration4DEE FrameworkBiogeochemical cycles

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