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    The p53 Gene and Cancer
    This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer.

    Keywords: Resources @ HHMI - BioInteractiveBiochemistrymolecular biologymacromoleculesGenetic disease

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    1999-Marchand-McDevitt-Learning Differential Equations by Exploring Earthquake Induced Structural Vibrations
    The project takes full advantage of analytical, numerical, and qualitative techniques to explore the mechanical vibrations of buildings during an earthquake.

    Keywords: earthquakenondimensionalizationCoulomb dampingmechanical vibration

    147

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    Antibody Binding
    This module introduces the Scatchard equation in the context of understanding antigen binding and the properties of antigens. It is intended for an introductory biology audience.

    Keywords: linear equationshyperbolic equationsCellular Processes

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    2017-Allali-EtAl-Mathematical Modeling of the Adaptive Immune Responses in the Early Stage of the HBV Infection
    The aim of this paper is to study the early stage of HBV infection and impact delay in the infection process on the adaptive immune response, which includes cytotoxic T-lymphocytes and antibodies.

    Keywords: logisticHBV infectionadaptive immunie responseT-lymphocytes

    121

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    6-017-OncolyticViruses-ModelingScenario
    Students explore oncolytic virotherapy using systems of differential equations and numerical simulations.

    Keywords: cancercancer-immune dynamicsimmune suppressor drugoncolytic virusvirotherapy

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    Harnessing the Power of the Immune System: Influenza Vaccines
    Because most people have been infected by and/or immunized against influenza, students should know how the immune system responds to the infection and how vaccines protect against disease. Vaccines...

    Keywords: VaccinesInfluenzaImmunizationVaccine efficacy

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    1-102C-CancerGrowth-ModelingScenario
    This module guides students in the use of differential equation models to predict cancer growth and study treatment outcomes. Several classical models for cancer growth are presented including...

    Keywords: optimizationcancerlogisticexponentialpredictiontumorgrowthdata fittingpower lawBertanffyGompertz

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    6-029-TumorGrowth-ModelingScenario
    This modeling scenario guides a student familiar with single ordinary differential equation (ODE) models towards the development of a more complex system of two ODEs for describing the evolution of...

    Keywords: Pop_Growth Pilotlogisticcomparmenttumorsynthetic datasum of squares error

    199

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    Inexpensive Cell Migration Inquiry Lab using Zebrafish
    Cell migration is an important and interesting topic that has the potential to engage students in cell biology by its intrinsically active nature. However, most ways to investigate cell migration...

    Keywords: CytoskeletonCell migrationmodel organisms

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    Antigen presentation and cytotoxic T lymphocytes (CTLs): elucidating a common roadblock for students
    Active learning resource for pre-Nursing anatomy and physiology lecture explaining antigen presentation to CTLs and how the CTLs recognize and destroy the pathogen using Biointeractive animations...

    Keywords: Resources @ HHMI - BioInteractiveimmune systemAnatomy & PhysiologyCell communication

    1100

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    Why do Some People Inherit a Predisposition to Cancer? A small group activity on cancer genetics
    Before undergraduate students take a genetics course they generally know cancer has a genetic basis and involves the proliferation of cells; however, many are uncertain about why only a subset of...

    Keywords: cancerInheritance patternsProbability calculationProto-oncogeneTumor Suppressor Gene

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    2006-Loyd-Wodarz-Drug Resistance in Acute Viral Infections-Rhinovirus as a Case Study
    We develop an epidemiological model that can be used to address the spread of resistance at the population level, and a virus dynamics model that can be used to study the dynamics of virus over the...

    Keywords: stabilityresistancevirusdrugepidemic competitionimmune responserhinovirus

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    How amphibians are impacted by Chytridiomycosis with Keely Rodriguez
    Keely Rodriguez is a Ph.D. student at the University of Nevada Reno in the Ecology, Evolution, and Conservation Biology department. In this interview, Keely discusses her background and her...

    Keywords: Disease ecologyamphibians

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    Targeting Infected Cells for Immune Defense
    This animation shows how a cell infected by a virus signals cytotoxic T cells to destroy itself.

    Keywords: Resources @ HHMI - BioInteractiveimmune systemAnatomy & PhysiologyCell communication

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    Analyzing Data on Behavioral and Immunological Effects of Inflammation in Mice
    In this activity, students will learn about behavioral and immunological responses to a bacterial infection. The activity emphasized the host’s responses rather than bacterial manipulation of the...

    Keywords: Vision and Changedata analysisImmunologybehaviorphysiologyinflammationinterdisciplinary educationAntigenmouseImmunoReachSicknessleukocyteneutrophilLipopolysaccharideacute phase response

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    Cell Cycle and Mitosis
    This module introduces activities that allow students to walk through the cell cycle and mitotic cell division processes. As part of the activities, students learn about and apply knowledge of...

    Keywords: introductory biologyQuantitative reasoningInterdisciplinary STEMquantitative biologyinterdisciplinaryquantitative skillscell functioncell cyclemitosisCell DivisionMitotic Indexcalculating meanstumorNIQBC2. Data and GraphsC4. mathematical modelsC3. Statistical Analysisstandard errormitotic phaseinterphase

    209

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    Using Raw Sequence Data to Analyze Tumor Suppressor Mutations
    Learning to identify DNA sequence variants from raw sequencing data (electropherograms) is a basic molecular biology skill with applications to basic research and clinical practice. Yet learning to...

    Keywords: bioinformaticsmutationDNAgenomic visualizationparts of a geneclinical consequencesraw data

    395

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    Using an Interactive Game, Gutsy, to Examine the Impacts of Pathogens and Everyday Events on the Human Gut Microbiome
    The human gut microbiome is often associated with ‘good bacteria’ in marketing campaigns for dietary supplements, probiotic drinks, and fermented foods. Yet, the dynamic and complex...

    Keywords: bacteriaGamepathogenhealthmicrobiomediversity

    174

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    Doubling Time of Tumors
    This module introduces the calculation of potential doubling time of tumorous cells in the context of understanding the growth of a population of the cells. It is intended for an introductory...

    Keywords: linear regressionRatiosCell StructureOpenStaxCell Growth

    991

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    Investigation of Subunit Interactions of Glyoxysomal Malate Dehydrogenase Using Engineered Cysteine Residues
    A research poster.

    Keywords: JoCURE

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