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    Targeting Infected Cells for Immune Defense
    This animation shows how a cell infected by a virus signals cytotoxic T cells to destroy itself.

    Keywords: Resources @ HHMI - BioInteractiveimmune systemAnatomy & PhysiologyCell communication

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    1-046-GoingViral-ModelingScenario
    Students participate in a simulation of the spread of a viral disease in the classroom and model the process with a logistic differential equation. The simulation uses random numbers and the entire...

    Keywords: simulationmathematical modeldatalogisticrandom number generatorfittingrandom process

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    2015-Joshi-EtAl-Optimal control of an SIR model with changing behavior through an education campaign
    We study stability analysis and use optimal control theory on the system of differential equations to achieve the goal of minimizing the infected population (while minimizing the cost).

    Keywords: SIR modelsvaccinepopulationwater treatmentsusceptibleeducation campaignminimizing costinfected

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    2002-Nelson-Perelson-Mathematical analysis of delay differential equations models of HIV-1 infection
    We develop and analyze a set of models that include intracellular delays, combination antiretroviral therapy, and the dynamics of both infected and uninfected T cells.

    Keywords: infectionHIVT cells

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    Modeling Strep Throat Detection, Infection, and Spread Using an SIR Model and the Vensim Simulation Software
    The overarching goal of this lesson is to provide students with an opportunity to gain experience making and using biological models. Biological modeling can be used to investigate complex,...

    Keywords: infectious diseasebiological modelingSIR model

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    2014-Bozkurt-Peker-Mathematical modelling of HIV epidemic and stability analysis
    A nonlinear mathematical model of differential equations with piecewise constant arguments is proposed. This model is analyzed by using the theory of both differential and difference equations to...

    Keywords: diseaselogisticHIVpiecewise constantIndia

    216

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    1-022-SpreadOfTechnologies-ModelingScenario
    We examine plots on the spread of technologies and ask students to estimate and extract data from the plots and then model several of these spread of technologies phenomena with a logistic...

    Keywords: data analysistechnologylogisticspreadinnovation

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    6-009-FakeNews-ModelingScenario
    In modern society, creating and disseminating information is easier than ever. In this project, you will model the spread of fake news and investigate ways to deter distributing misinformation.

    Keywords: sensitivity analysisSIR modelsSIS modelfake news

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    Antigen presentation and cytotoxic T lymphocytes (CTLs): elucidating a common roadblock for students
    Active learning resource for pre-Nursing anatomy and physiology lecture explaining antigen presentation to CTLs and how the CTLs recognize and destroy the pathogen using Biointeractive animations...

    Keywords: Resources @ HHMI - BioInteractiveimmune systemAnatomy & PhysiologyCell communication

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    2018-Arden_Baxter-Modeling Public Opinion
    In this paper, we adapt the epidemiological models to model the dynamics of public opinion. Public opinion is any view prevalent among the general public. Our model considers any topic or issue in...

    Keywords: epidemiologypopulationpublic opinion

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    2012-Tweedle-Smith-Mathematical model of Bieber Fever-The most infectious disease of our time
    We develop a mathematical model to describe the spread of Bieber Fever, whereby individuals can be susceptible, Bieber-infected or bored of Bieber.

    Keywords: infectious diseasediseaseinfectionmediaJustin BieberBieber feversymptomsboredreproductive ratio

    153

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    2002-Patrick_Nelson-Alan_Perelson-Mathematical_analysis_of_delay_differential _equation_models_of_HIV-1_infection
    Models of HIV-1 infection that include intracellular delays are more accurate representations of the biology and change the estimated values of kinetic parameters when compared to models without...

    Keywords: delayHIV-1T cellscombination antiviral therapy

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    1-084-GoingViral-ModelingScenario
    Students employ randomization in order to create a simulation of the spread of a viral disease in a population (the classroom). Students then use qualitative analysis of the expected behavior of...

    Keywords: simulationlogisticrandomfittingpartial fractions

    262

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    2018-Meredith_Greer-Ella_Livesay-Mathematical Epidemiology Goes to College
    In this article we present models that were inspired by two real-life outbreaks at a small residential college campus: H1N1 influenza in 2009 and, surprisingly, mumps in 2016.

    Keywords: epidemiologydiseaseH1N1Influenzaoutbreak

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    6-016-PandemicModeling-ModelingScenario
    The recent coronavirus outbreak has infected millions of people worldwide and spread to over 200 countries. How can we use differential equations to study the spread of coronavirus?

    Keywords: population dynamicsinfectious diseasediseaseEbolaeSIR modelsCOVID19pandemicepidemicreproduction number

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    6-018-ExploringSIRModel-ModelingScenario
    Students will transform, solve, and interpret Susceptible Infected Recovered (SIR) models using systems of differential equation models. The project is progressively divided into three parts to...

    Keywords: population dynamicssensitivitydiseaseSIR modelsepidemicrumors

    266

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    6-017-OncolyticViruses-ModelingScenario
    Students explore oncolytic virotherapy using systems of differential equations and numerical simulations.

    Keywords: cancercancer-immune dynamicsimmune suppressor drugoncolytic virusvirotherapy

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    Connecting Viral Pandemics to Ecological Population Growth Models
    In this activity students use the HHMI Population Growth Models interactive to explore R0 for diseases and discuss the importance of connecting population ecology to current events like the...
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    The effects of Avian Malaria On Pigeon Fledging Growth
    Poster on a case that combined Biology and Statistics in a student research project presented at the 2018 QUBES/BioQUEST Summer Workshop

    Keywords: biostatisticsstatistical analysisavian malariaSummer Workshop 2018

    1272

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    Parasite Patrol: Lifecycle Game
    Parasite Patrol is a detective-style game about parasite lifecycles suitable for use in university or K-12 settings. The goal of the game is for participants to role-play parasite detectives who...

    Keywords: parasitesGamelife cycleBoard game

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