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    Using Raw Sequence Data to Analyze Tumor Suppressor Mutations
    Learning to identify DNA sequence variants from raw sequencing data (electropherograms) is a basic molecular biology skill with applications to basic research and clinical practice. Yet learning to...

    Keywords: bioinformaticsmutationDNAgenomic visualizationparts of a geneclinical consequencesraw data

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    Using Undergraduate Molecular Biology Labs to Discover Targets of miRNAs in Humans
    In this lesson, we describe an easily adaptable lab module that can be used in existing undergraduate molecular biology lab courses to conduct authentic scientific research, published in CourseSource

    Keywords: molecular biologybioinformaticsNIBLSEgene regulationmicroRNAsgene expressionCourseSourcemiRNA

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    Investigating Gene Expression and Cell Specialization in Axolotl Embryos
    The process of cell specialization is critical to the formation and function of tissues in animals and plants. Although gene expression, including the regulation of transcription, is taught in most...

    Keywords: developmenttranscriptiongene expressionmodel organismembryo

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    Happy Blue Baby
    This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved on its own...

    Keywords: mutationHemoglobinmolecular visualization and analysisgenetic basisPDBMolecular Case StudyMol*

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    CRISPR Gene Editing: Designing the gRNA and Donor Template
    In this adaptation, students learn how CRISPR/Cas9 is used in bacterial immunity and gene editing. Students create both a gRNA target and a donor template to edit a gene. Mutations can be from the...

    Keywords: geneticseducationcell biologymolecular biologymutationStem cellsstructure-functionmolecular visualization and analysis3D protein structure /function analysisCRISPR/Cas9crisprDNA mutationPiwiPDBMolecular Case StudyPiwi Matters

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    Piwi Matters
    This case focuses on understanding structure and function relationships in Piwi, a protein that is critical for germline stem cell function and development of eggs in the fruit fly ovary.

    Keywords: Stem cellsmolecular visualization and analysis3D protein structure /function analysisPiwiPDBMolecular Case Study

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    Happy Blue Baby
    This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved on its own...

    Keywords: mutationHemoglobinmolecular visualization and analysisPDBMolecular Case Study

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    Morphological, Anatomical and Molecular Analysis of Plant Phylogeny and Diversity
    In this lab, students perform phylogenetic analyses on morphological, anatomical and molecular data, and compare.

    Keywords: morphologyphylogenylaboratoryplantsmolecular analysisstele architecture

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    2009-Peter-Howard-Modeling With ODE
    This is a set of class notes rich in examples and ideas for modeling. There is some MatLab code in support of some of the activities.

    Keywords: ratescompetitionpopulationepidemicpendulumcarbon datingreaction chemistrymechanicsplanetary motiondrag racingHamilton’s methodvariational method

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    2013-Alicia_Caldwell-Students Rise to the Challenge of Modeling Yeast Growth Despite Sour Hiccups from Imperfect Data
    This paper describes a lab in which students in an Applied Mathematics in Biology course observe the growth of Saccharomyces cerevisiae, a yeast strain, in differing sugar concentrations for use in...

    Keywords: Saccharomyces cerevisiaelogisticyeastdeathgrowthsugaralcohol

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    2019-Ekici_Plyley. Inquiry-Based_Modeling_of_Population_Dynamics_With_Logistic_Differential_and_Difference_Equations
    Inquiry-based learning activities on modeling and controlling the growth of locally relevant species, such as lionfish or sea turtles, are developed by the authors.

    Keywords: population dynamicslogisticInquiry-based modelingIBL

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    A 360˚ View of COVID-19
    In March 2020, institutions underwent a massive transition to distance learning as a result of the COVID-19 pandemic. With so little time to devise new materials to maximize learning in the new...

    Keywords: geneticsImmunologyBiochemistrybioinformaticsmolecular evolutionpublic healthvirusCOVID19

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    The Case of the Missing Strawberries: RFLP analysis
    While solving the fictional mystery of the missing strawberries, students are engaged in a guided-inquiry lesson featuring small-group and class discussions, hands-on activities, and laboratory...

    Keywords: process of scienceDNAforensicsgel electrophoresisMolecular genotypingRestriction endonucleaseRestriction enzymeRestriction fragment length polymorphismRFLP

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    Simulating Cortical Rotation, Axis Induction, and Experimental Embryology in Amphibian Embryos Using Clay Models
    The study of development requires learners to understand spatially complex concepts like embryo anatomy. Embryo anatomy is dynamic over time, and it is often manipulated by researchers in...

    Keywords: developmentXenopusfertilizationEmbryologyinductionSymmetry breakingOrganizerCortical rotationPatterning

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    Using Bioinformatics and Molecular Visualization to Develop Student Hypotheses in a Malate Dehydrogenase Oriented CURE
    Developing student creativity and ability to develop a testable hypothesis represents a significant challenge in most laboratory courses. This lesson demonstrates how students use facets of...

    Keywords: bioinformaticsNoncovalent InteractionsEnzyme CatalysisProtein Structure/function

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    2013-Clarke-Skirba-Rationale and resources for teaching the mathematical modeling of athletic training and performance
    It is advisable that the professionals involved learn the various tools available for designing effective training programs.

    Keywords: fitnessexercise physiologycritical power modelBanister impulse-response modelcoaching educationphysical fitnessperformance modeling

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    2015-H_Sayama-Intro to Modeling and Analysis of Complex Systems
    Introduces students to mathematical/computational modeling and analysis developed in the emerging interdisciplinary field of Complex Systems Science.

    Keywords: textbooktext

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    1988-EY_Rodin-N_Taber-Yeast Growth Modelling in a Laboratory
    Modeling simple growth with some missing data and doing linear regression for parameter estimation in closed form solution of differential equation model and data.

    Keywords: regressionyeastgrowth

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    Trout modeling example
    This is an open-ended modeling example using difference equations and Algebra II skills.

    Keywords: population biology

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    Modeling: A Primer - The crafty art of making, exploring, extending, transforming, tweaking, bending, disassembling, questioning, and breaking models
    Explore how to use, analyze, and criticize some important and historically influential models in biology in this text only module.

    Keywords: modelingsimulationmoduleResources @ BioQUESTtextbookmodulesmathematical modeling

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