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    Building a Model of Tumorigenesis: A small group activity for a cancer biology/cell biology course
    The multistep nature of tumorigenesis is a foundational concept in the context of Cancer Biology. Many students do not appreciate the complex nature of cancer development nor do they understand how...

    Keywords: pathwayscancerMolecular AlterationsRetrospective dataTumorigenesis

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    Why do Some People Inherit a Predisposition to Cancer? A small group activity on cancer genetics
    Before undergraduate students take a genetics course they generally know cancer has a genetic basis and involves the proliferation of cells; however, many are uncertain about why only a subset of...

    Keywords: cancerInheritance patternsProbability calculationProto-oncogeneTumor Suppressor Gene

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    The Science Behind Parthenogenesis: Interesting things happen when meiosis goes “wrong”
    Parthenogenetic reproduction is a fascinating, complex topic.  This article accompanies “Why Meiosis Matters: The case of the fatherless snake.” It summarizes the basic information...

    Keywords: meiosismitosissex determinationAsexual reproductionParthenogenesis

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    Mol* Adaptation: Case of Severe Insulin Resistance
    This is an adaptation using Mol* on the original case written. This case focuses on understanding how a mutation in a cell signalling protein (a kinase) can prevent insulin function and lead to...

    Keywords: molecular visualization and analysisPDBMolecular Case Studyinsulin resistanceMol*MolStar

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    Happy Blue Baby
    This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved on its own...

    Keywords: mutationHemoglobinmolecular visualization and analysisgenetic basisPDBMolecular Case StudyMol*

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    Happy Blue Baby: MCQs for large classes
    Multiple choice questions for the Happy Blue Baby case study pre-work

    Keywords: mutationHemoglobinmolecular visualization and analysisPDBMolecular Case Study

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    CRISPR Gene Editing: Designing the gRNA and Donor Template
    In this adaptation, students learn how CRISPR/Cas9 is used in bacterial immunity and gene editing. Students create both a gRNA target and a donor template to edit a gene. Mutations can be from the...

    Keywords: geneticseducationcell biologymolecular biologymutationStem cellsstructure-functionmolecular visualization and analysis3D protein structure /function analysisCRISPR/Cas9crisprDNA mutationPiwiPDBMolecular Case StudyPiwi Matters

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    Sickle Cell Anemia using Nicholas’ Story
    The goal of this exercise is to introduce students to 3-D structures of biological molecules, visualize and manipulate them to understand their functions. The exercise also helps them see the...

    Keywords: Hemoglobinsickle cell diseaseMolecular Case Study

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    Molecular Basis of Sickle Cell Disease
    This multi part case on hemoglobin structure as it relates to oxygen binding and sickle cell disease focuses on utilizing bioinformatics and molecular visualization tools to learn about the sickle...

    Keywords: Hemoglobinmolecular visualization and analysisintroductory bioinformaticssickle cell diseasePDBMolecular Case Studyoxygen bindingmyoglobinmolecular literacy3D protein structuresstructural representations

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    The Happy Blue Baby Hemoglobin
    This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved.

    Keywords: mutationHemoglobinmolecular visualization and analysisPDBMolecular Case Study

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    A Case of Severe Insulin Resistance
    This case focuses on understanding how a mutation in a cell signalling protein (a kinase) can prevent insulin function and lead to diabetes.

    Keywords: molecular visualization and analysisPDBMolecular Case Studyinsulin resistance

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    Happy Blue Baby
    This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved on its own...

    Keywords: mutationHemoglobinmolecular visualization and analysisPDBMolecular Case Study

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    Exploring Population Change without Selection: Avida-Ed Lab Book Exercise 4
    An introductory activity exploring how a population changes without natural selection using the Avida-ED simulation.

    Keywords: population geneticsEvolutionavida-edsoftware simulationsSelection

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    Exploring Random Mutation and Selection: Avida-Ed Lab Book Exercise 2
    An introductory activity exploring the role of random mutation in natural selection using the Avida-ED simulation.

    Keywords: avida-edmutationsoftware simulationsSelectionvariation

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    Exploring the Introduction of Genetic Variation by Random Mutation: Avida-Ed Lab Book Exercise 1
    An introductory activity introducing the role of random mutation in generating genetic variation using the Avida-ED simulation.

    Keywords: geneticsEvolutionavida-edmutationsoftware simulations

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    That Vertebrate Ate What Exactly?
    During the course of this lesson, students will analyze CT scan data and observe bycatch (or an unknown discovery) captured during the scanning process of vertebrates.

    Keywords: EvolutionidigbioAP Biologynatural history collections3D modelsanatomy and physiology#NGSSVertebrate MorphologyCT scanoVert

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    Sickle Cell Disease Case Study
    A short film explores the evolutionary connection between an infectious disease, malaria, and a genetic condition, sickle cell anemia. The animation explores the genetic causes and biological...

    Keywords: HHMI BioInteractive

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    Louse Genetics, Genomics, and Gene Function...Oh My!
    In this module, students will be investigating a louse gene with an unknown function to determine if it might be important in the evolution of the louse ecomorphs.

    Keywords: parasitesgenomicsgene sequence analysisFunctional Genomics

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    Sickle Cell Disease and Natural Selection in Humans
    A short film explores the evolutionary connection between an infectious disease, malaria, and a genetic condition, sickle cell anemia. The animation explores the genetic causes and biological...

    Keywords: HHMI BioInteractive

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    Mutation and Equilibrium Worksheet
    This is a worksheet created for students to complete when doing the Mutation and Equilibrium MathBench activity.
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