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The QUBES platform hosts hundreds of teaching materials, reference materials, and cloud-based software free to use and adapt using open Creative Commons licenses.

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    Phylogeography Simulator
    This Excel workbook simulates the phylogeography of an asexually reproducing species.

    Keywords: Phylogeographymutation ratesAsexual reproductionspecies dispersal

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    Web Popgen
    A Hardy-Weinberg simulation program.

    Keywords: Hardy-Weinbergpopulation geneticscomputer simulationsGenetic DriftmutationNatural Selection

    2111

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    345

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    Murder by HIV? Undergraduate edition
    Bioinformatics case study focusing on phylogenetic tree interpretation, published in the National Center for Case Study Teaching in Science

    Keywords: case studyResources @ NSF - NCCSTSbioinformaticsNIBLSEHIVnucleotide sequencingphylogenetic treeviral life cyclesmutation ratesreverse transcriptase sequences

    1599

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    135

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    Mutation and Selection: An Exploration of Antibiotic Resistance in Serratia Marcescens
    This laboratory module gives students hands-on experience with mutation and selection in bacteria.

    Keywords: moduleinquiry labsmutationartificial selectionbacteriain-class activityHandoutlab protocolResources @ QUBES - Teaching & Referenceantibiotic-resistance

    1282

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    247

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    Exploring Random Mutation and Selection: Avida-Ed Lab Book Exercise 2
    An introductory activity exploring the role of random mutation in natural selection using the Avida-ED simulation.

    Keywords: avida-edmutationsoftware simulationsSelectionvariation

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    Luria-Delbruck
    These two workbooks model the evolution of phage resistance in a bacterial population under two alternative hypotheses.

    Keywords: phageLuria-Delbruckresistance

    1563

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    283

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    2

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    Diseasebots HEXBUG Lab
    This module explores the effects of host density on contact rates and transmission of pathogens using a hands-on experiment with HEXBUG robots.
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    Sickle Cell Disease and Natural Selection in Humans
    A short film explores the evolutionary connection between an infectious disease, malaria, and a genetic condition, sickle cell anemia. The animation explores the genetic causes and biological...

    Keywords: HHMI BioInteractive

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    462

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    CRISPR Gene Editing: Designing the gRNA and Donor Template
    In this adaptation, students learn how CRISPR/Cas9 is used in bacterial immunity and gene editing. Students create both a gRNA target and a donor template to edit a gene. Mutations can be from the...

    Keywords: geneticseducationcell biologymolecular biologymutationStem cellsstructure-functionmolecular visualization and analysis3D protein structure /function analysisCRISPR/Cas9crisprDNA mutationPiwiPDBMolecular Case StudyPiwi Matters

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    806

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    Application of a Bacterial Experimental Evolution System to Visualize and Teach Evolution in Action: A Course-Based Undergraduate Research Experience
    Concepts of evolution are typically taught through examples of extremely long timescales, which do not always resonate broadly. Here, we describe a course-based undergraduate research experience...

    Keywords: EvolutionmutationcompetitionNatural Selectionregulationstructure and functionreproductive fitnessgenotype to phenotypehomologs

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    2005-DieboldEtAl-Modeling Bond Yields In Finance And Macroeconomics
    From a macroeconomic perspective, the short-term interest rate is a policy instrument under the direct control of the central bank. From a finance perspective, long rates are risk-adjusted averages...

    Keywords: financeinterest ratebond yieldmacroeconomics

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    Linking Genotype to Phenotype: The Effect of a Mutation in Gibberellic Acid Production on Plant Germination
    Basic concepts in genetics and plant development are often taught in lecture courses without a lab component. This approach provides students with the content knowledge, but fails to make...

    Keywords: geneticsdevelopmentmutationgerminationplantmodel organismGenotype/PhenotypeHormoneSeed

    2609

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    572

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    AVIDA exercise on the role of mutation in evolution
    A tested exercise at the college freshmen level using AVIDA-Ed to generate and test a hypothesis about the relationship between mutation rate and the probability of evolving a useful function in...
    998

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    75

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    Sickle Cell Disease Case Study
    A short film explores the evolutionary connection between an infectious disease, malaria, and a genetic condition, sickle cell anemia. The animation explores the genetic causes and biological...

    Keywords: HHMI BioInteractive

    2123

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    1786

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    Exploring the Introduction of Genetic Variation by Random Mutation: Avida-Ed Lab Book Exercise 1
    An introductory activity introducing the role of random mutation in generating genetic variation using the Avida-ED simulation.

    Keywords: geneticsEvolutionavida-edmutationsoftware simulations

    1035

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    857

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    Mutation and Equilibrium Worksheet
    This is a worksheet created for students to complete when doing the Mutation and Equilibrium MathBench activity.
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    Cell Biology by the Numbers
    Vignettes that reveal how numbers serve as a sixth sense to understanding our cells

    Keywords: datacell biologyNumbersratesconcentrationMeasurementestimation

    1344

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    Advancing population ecology with integral projection models: a practical guide
    Integral projection models (IPMs) use information on how an individual's state influences its vital rates – survival, growth and reproduction – to make population projections using regression...

    Keywords: IPMintegral projection modelspopulation growthreviewsdemographyelasticitylife historymatrix projection modelpopulation growth ratesensitivitystage structurevital ratesregressionResources @ QUBES - Teaching & Referencecovariatesanalytics

    1000

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    208

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    A Muscular Dystrophy Case Study Illustrating the Phenotypic Effects of Mutation
    Mutations in genes can lead to a variety of phenotypes, including various human diseases. Students often understand that a particular mutation in a single gene causes a disease phenotype, but it is...

    Keywords: mutationProtein Structureethicscentral dogmahuman disease

    2952

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    339

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    Using Synthetic Biology and pClone Red for Authentic Research on Promoter Function: Genetics (analyzing mutant promoters)
    Students often memorize the definition of a transcriptional promoter but fail to fully understand the critical role promoters play in gene expression.  This laboratory lesson allows students...

    Keywords: bacteriasynthetic biologygene regulationtranscriptionstudent researchcentral dogmacloningpromoterreporter gene/protein

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    730

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