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    Antigen presentation and cytotoxic T lymphocytes (CTLs): elucidating a common roadblock for students
    Active learning resource for pre-Nursing anatomy and physiology lecture explaining antigen presentation to CTLs and how the CTLs recognize and destroy the pathogen using Biointeractive animations...

    Keywords: Resources @ HHMI - BioInteractiveimmune systemAnatomy & PhysiologyCell communication

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    Electrical Activity of Neurons
    This tutorial describes how neurons generate action potentials, and how scientists measure neuronal activity and record the firing of individual neurons.

    Keywords: Resources @ HHMI - BioInteractiveAnatomy & PhysiologyNervous systemCell communication

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    Building Trees: Introducing evolutionary concepts by exploring Crassulaceae phylogeny and biogeography
    Teaching evolutionary theory is foundational for all biological sciences and a key aspect of overall science literacy. The conceptual framework for understanding evolution relies on thinking...

    Keywords: EvolutionphylogeneticsTree thinkingbiogeography

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    Bioinformatics: Investigating Sequence Similarity - A Plant Biology Approach
    This laboratory module is a modification of the original published on CourseSource with a focus on plant biology. In the final activity, students conduct a BLAST to compare histone protein...

    Keywords: phylogeneticsbioinformaticssequencingFASTANCBIplant biologyNIBLSEalgorithmsincubatorsPlant and Fungal EvolutionBLASTmultiple sequence alignmentsequence similarityBLOSUM scoring matrixneighbor-joining distance matrixCourseSourcephylogram

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    The impact of diet and antibiotics on the gut microbiome
    The goal of this article is to describe an active learning exercise that can be used in a variety of advanced microbiology courses, including bacterial physiology, ecology, or systems biology. The...

    Keywords: microbiomeenvironmental controlhost responsemetabolites

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    Using Regression Models to Examine the Effect of Carbon Dioxide on Fluid pH
    In this activity students will use statistics and regression models to explore the effects of carbon dioxide on blood pH by measuring pH changes that occur over time as carbon dioxide reacts with...

    Keywords: BiochemistryphysiologyAnatomyGeneral BiologyChoosing modelsCreate graphsInterpret graphsConcepts in Statisticscreate modelsmake predictions

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    2006-Han-EtAl-Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology
    Physiologically-based pharmacokinetic (PBPK) models have been used to describe the distribution and elimination characteristics of intravenous ethanol administration.

    Keywords: liverwortsintraveneouspharmacokineticsethanolethanol infustionpharmacodynamictissue model

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    Regulation of Sex Determination
    This activity accompanies the HHMI BioInteractive module Sex Verification of Athletes (​https://www.hhmi.org/biointeractive/testing-athletes​). It provides students with exercises to explore the...
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    2007-Zenker-Rubin-Clermont-From inverse problems in mathematical physiology to quantitative differential diagnoses
    The improved capacity to acquire quantitative data in a clinical setting has generally failed to improve outcomes in acutely ill patients, suggesting a need for advances in computer-supported data...

    Keywords: physiologyinverse problem

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    Coloring and Keying Great Lakes Trees
    In this set of activities, you will use the Michigan Trees Coloring book to learn and practice plant identification. You will also simulate some of the steps of specimen preparation by keying an d...

    Keywords: BiodiversitytaxonomyHerbarianatural history education

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    An Introduction to the R Programming Environment
    An online module introducing students and biologists to R, published in American Phytopathological Society

    Keywords: epidemiologyRecologyR programming languagebioinformaticsprogrammingplant biologyNIBLSEplant pathology

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    PLANT Talking Points: Economic Botany - how we value plants...
    This resource gives insight into the interactions between humans and the environment.

    Keywords: sustainabilitybotanyenvironmentethnobotany

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    Large Datasets in R - Plant Phenology & Temperature Data from NEON
    This module series covers how to import, manipulate, format and plot time series data stored in .csv format in R. Originally designed to teach researchers to use NEON plant phenology and air...

    Keywords: data in the classroomtool:rstudiophenologydata managementNEONtemperature

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    Teaching Notes for Investigating the footprint of climate change on phenology and ecological interactions in north-central North America
    This is an FMN participant supplement for the TIEE module "Investigating the footprint of climate change on phenology and ecological interactions in north-central North America," authored...

    Keywords: ecologyLabfmnLectureUndergraduateData DiscoveryInstructional SettingAudience LevelAdvancedActivity LengthMore than 1 hour

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    Teaching Notes for Global Temperature Change in the 21st Century
    This is an FMN participant supplement for the TIEE module "Global Temperature Change in the 21st Century," authored by Daniel R. Taub and Gillian S. Graham in 2011.

    Keywords: ecologyLabfmnLectureUndergraduateData DiscoveryInstructional SettingAudience LevelAdvancedActivity LengthMore than 1 hour

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    2014-Yahdi-EtAl-Modeling and Sensitivity Analysis of the Role of Biodiversity to Control Pest Damage in Agroecosystems
    The paper provides a mathematical framework for cost-effective and environmentally safe strategies to minimize alfalfa damage from pests in alfalfa agroecosystems with optimal biodiversity levels.

    Keywords: sensitivity analysispredatorsteady statealfalfaShannon diversity indexplant herbivore

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    The Effect of Different Fertilizer Treatments on the Sprouting Time and Growth of Cosmos seeds, seeds of the genus Myosotis Forget-Me-Not seeds, and Cruciferae Brassica nigra Mustard seeds
    During the past decade, climate change has become an important topic. A few ramifications include an excess amount of carbon dioxide and rising temperatures. It is predicted that ecosystems may...

    Keywords: agriculture

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    1-139-PlantsVsHerbivores-ModeliongScenario
    In this activity, students will apply a variety of techniques for analyzing nonlinear systems (e.g., nullclines, linearization, and technologies for drawing phase portraits) to study...

    Keywords: ecologynullclinesherbivoreplant-herbivore interactionsplantlinearization

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    A Phenology-focused CURE using Herbarium Specimen Data
    10-week course-based undergraduate research experience in which students conduct novel research on the effects of climate on phenological events (e.g., flowering) of a plant species using publicly...

    Keywords: phenologyScientific ProcessCURE

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    Attract or Defend? Secondary Compounds among tissues in two species of Lupine (Fabaceae)
    This plant-biology data analysis module compares concentrations of defensive alkaloid compounds among tissue types in two species of the flowering-plant Lupine (Fabaceae). Students practice with...
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