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    Targeting Misconceptions in the Central Dogma by Examining Viral Infection
    Understanding the central dogma and how changes in gene expression can impact cell function requires integration of several topics in molecular biology. Students often do not make the necessary...

    Keywords: datatranscriptionvirustranslationprotein functionmembrane transportPredictions

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    Exploring Miracle Fruit: An Undergraduate Laboratory Exercise on Experimental Design
    In recent years, undergraduate biology and biochemistry curricula have seen an increase in the use of course-based undergraduate research experiences (CUREs). CUREs maximize potential student gains...

    Keywords: sensory systemspHProtein shapeTaste

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    Problem-Based Learning for Physiology: Synthesizing the Cardiovascular System, Respiration, Macronutrient Metabolism, and Renal Function
    Problem Based Learning (PBL) is a valuable tool for helping students overcome reliance on memorization by scaffolding opportunities for them to practice the competency of...

    Keywords: MetabolismObesityblood pressurecardiac functioncardiovascularmetabolic syndromerenalRespirationrespiratory system

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    Single Cell Insights Into Cancer Transcriptomes: A Five-Part Single-Cell RNAseq Case Study Lesson
    There is a growing need for integration of “Big Data” into undergraduate biology curricula. Transcriptomics is one venue to examine biology from an informatics perspective. RNA sequencing has...

    Keywords: bioinformaticscancertranscriptomicshigh-throughputData wranglingSingle cell RNA sequencingq

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    An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure
    Gene structure, transcription, translation, and alternative splicing are challenging concepts for many undergraduates studying biology. These topics are typically covered in a traditional lecture...

    Keywords: bioinformaticsGenome BrowsergenomicsRNAseqsplicingComputer ModelGene Structure

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    Investigating Enzyme Structure and Function Through Model-Building and Peer Teaching in an Introductory Biology Course
    A foundational knowledge of the relationship between structure and function is critical to understanding how enzymes work. The seemingly invisible nature of these molecular interactions makes it...

    Keywords: structure-functionEnzymeallosteric regulationcompetitive inhibitionfeedback inhibitionnoncompetitive inhibitionproductsubstrate

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    Breaking Bricks: A Hands-On Model of Enzyme Kinetics and Inhibition
    Enzyme kinetics and the impacts of inhibitors on the enzyme's maximal velocity and ability to bind substrates are important topics in cell biology and biochemistry. However, these topics can be...

    Keywords: kineticsEnzymecompetitive inhibition

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    Cutthroat trout in Colorado: A case study connecting evolution and conservation
    Evaluation of evidence is a key process skill for the core competencies of applying the process of science and using quantitative reasoning. This case study enables upper-division biology students...

    Keywords: population geneticsphylogeneticsSpeciationdivergencegene flow

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    Exploring the Lytic and Lysogenic Life Cycles of Bacteriophages
    The goal of this lesson is to introduce students to the lytic and lysogenic cycles of T4 and lambda bacteriophages, respectively, using student-centered pedagogies. Bacteriophages are viruses that...

    Keywords: bacteriophagesLysogenic cycleLysogenyLytic cycle

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    Generating Biological Hypotheses in a "Course-based Undergraduate Research Experience"(CURE) Course
    Hypotheses are often incorrectly defined as educated guesses or if/then statements. Further confusion arises from the fact that not all disciplines define hypotheses similarly. The difficulty in...

    Keywords: scientific methodHPT axisNeural stem cells

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    Engaging Undergraduates in Mechanisms of Tubular Reabsorption and Secretion in the Mammalian Kidney
    If students fail to see the connections among physiological systems, they can become overwhelmed with the amount of information they need to learn. Some students have particular difficulty with the...

    Keywords: OsmosisActive transportMass flowRenal reabsorptionRenal secretionTransport across membranes

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    Lateral Transfer Maps as a Metacognitive Tool in First Year STEM Courses
    We introduce the Lateral Transfer Map (LTM), a tool for students to actively and visually explore the transfer of ideas, skills, and concepts across concurrent coursework. The LTM is an extension...

    Keywords: concept mapmetacognitionfirst-year studenttransfer

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    Understanding Gastric Acid Secretion: An Active Learning Approach
    The human digestive system is a diverse network of cells, tissues, and organs that is regulated by systemic (e.g., nervous and endocrine systems) and local factors (e.g., secretions, pH, and the...

    Keywords: diseasesignal transductionAcid SecretionAutonomic Nervous SystemEndocrineGastric PhysiologyGPCRHistology of Gastric Pit

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    Using Musical Instruments to Model Negative Feedback in the Hypothalamo-Pituitary-Target Gland Axes
    Homeostasis and negative feedback are crucial, yet difficult, concepts for undergraduates, particularly in the context of the hypothalamo-pituitary axes. This interactive activity was designed to...

    Keywords: cell-cell communicationhomeostasisnegative feedback

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    Integrating Manipulatives and Animations to Visualize Holliday Junctions
    The complex molecular architecture of Holliday junctions is often challenging for undergraduate biochemistry students to conceptualize. In particular, they have difficulty translating from...

    Keywords: dna structureDNA damageDNA recombinationGene crossoverHolliday junction

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    Green Design: How do Leaf Structures Optimize Photosynthesis and Promote Survival?
    One of the major learning objectives established by the American Society of Plant Biologists and the Botanical Society of America has students answer the question: How do plant structures enable...

    Keywords: photosynthesisepidermal layerleaf anatomymesophyllpalisade parenchymaplant anatomyplant structure functionspongy parenchymaStomata

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    Using Zebrafish in a Developmental Biology Lab Course to Explore Interactions Between Development and the Environment
    Important learning outcomes for biology students include the ability to develop experiments as well as pull together concepts across their coursework. The field of developmental biology, especially...

    Keywords: toxicologymorphogenesisorganogenesis

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    Investigating Gene Expression and Cell Specialization in Axolotl Embryos
    The process of cell specialization is critical to the formation and function of tissues in animals and plants. Although gene expression, including the regulation of transcription, is taught in most...

    Keywords: developmenttranscriptiongene expressionmodel organismembryo

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    Using Immunocytochemistry and Fluorescence Microscopy Imaging to Explore the Mechanism of Action of Anti-Cancer Drugs on the Cell Cycle
    Understanding and visualizing the cell cycle and mitosis is an essential concept of cell biology. This multi-week lab module has students investigate the mechanism of action of anti-cancer drugs...

    Keywords: fluorescence microscopymitosisCell StructureCell ImagingImmunocytochemistryQuantitative microscopySTEM skills

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    Necessary and Sufficient? Solving the Mystery of the Mitochondrial Pyruvate Transporter
    While there are several available lessons for teaching introductory biology students about diffusion, facilitated diffusion, and active transport, fewer materials exist to support upper-division...

    Keywords: DiffusionActive transportfacilitated diffusionNecessary and sufficientTransport proteins

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