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    An undergraduate bioinformatics curriculum that teaches eukaryotic gene structure
    Gene structure, transcription, translation, and alternative splicing are challenging concepts for many undergraduates studying biology. These topics are typically covered in a traditional lecture...

    Keywords: bioinformaticsGenome BrowsergenomicsRNAseqsplicingComputer ModelGene Structure

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    Sin Nombre Hantavirus in the US
    A module guiding students through the review of different biodiversity data sources to identify patterns in the distribution of the Sin Nombre Hantavirus in the United States. English, Spanish, and...

    Keywords: Resources @ AIM-UP!infectious diseasespublic healthnatural history collectionsWildlife Diseasedigitized natural history collectionsenglishSpanishzoonotic diseaseshantavirusMEPAPortuguesetranslated

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    Understanding Gene Prediction Programs
    Introduces students to the key biological concepts underlying computational gene prediction. Outcomes include ability to analyze and evaluate output of gene prediction programs, and reflect on...

    Keywords: Genome annotationSEA-PHAGESgene predictiongenemarkcoding potentialcodon biassix frame translation

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    Biogeography of Hantavirus Hosts
    Using QGIS, this module introduces students to zoonotic pathogens, host biogeography, the "One Health" concept, forming hypothesis, and natural history museums within the Hantavirus system.

    Keywords: human-environmental interactionsmammalsbiogeographyhypothesis formulationdigitized natural history collectionshuman healthQGISzoonotic diseasesone healthrodentsPathogens

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    Predicting and classifying effects of insertion and deletion mutations on protein coding regions
    Mutations in genes can affect the encoded proteins in multiple ways, and some of these effects are counterintuitive. As for any other knowledge, students must create their own deep understanding of...

    Keywords: mutationcentral dogmatranslationframeshift

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    1-005-OilSlick-ModelingScenario
    We describe a modeling activity with difference and differential equations which enlightens students on the model building process and parameter estimation for a linear, first-order,...

    Keywords: model fittingspreadsheetsSpanishderrame de petróleodatosexpansiónoil slick

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    Translating Co-Translational Translocation
    Understanding the process of proteins targeting to specific locations within a cell is a fundamental part of cell biology. Synthesis of proteins by co-translational translocation, which also...

    Keywords: Topologyco-translational translocationendoplasmic reticulumprotease protection assaysecretory proteinssignal sequencetransmembrane proteins

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    Garden Variety Mutations: Using Primary Data to Understand the Central Dogma in Large-Lecture Introductory Biology
    The ability to interpret and create an argument from data is a crucial skill for budding scientists, yet one that is seldom practiced in introductory courses. During this argumentation module,...

    Keywords: mutationtranscriptiongene expressioncentral dogmatranslationgel electrophoresisGenotype/Phenotype

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    1999-T_Chen-HL_He-GM_Church-S_Shafer-Modeling Gene Expression with Differential Equations
    The paper proposes and give great detail for a differential equation model for gene expression with two methods for constructing the model from a set of temporal data.

    Keywords: gene expressiongenekineticgene translationgene transcription

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    Intro videos and terminology for GMOs, Transcription, Translation
    Compiled resources around GMOs and protein production including vocabulary, animations, videos, and games

    Keywords: geneticsagricultureplantstranscriptiongenomesGMOtranslation

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    Targeting Misconceptions in the Central Dogma by Examining Viral Infection
    Understanding the central dogma and how changes in gene expression can impact cell function requires integration of several topics in molecular biology. Students often do not make the necessary...

    Keywords: datatranscriptionvirustranslationprotein functionmembrane transportPredictions

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    1-031-CoolIt-ModelingScenario
    We offer data on the temperature of water in a beaker in a room of constant temperature and in a room of nonconstant temperature. Students consider both empirical and analytic modeling...

    Keywords: SpanishNewton's Law of Coolingcooling

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    1-015-Torricelli-ModelingScenario
    We help students develop a model (Torricelli's Law) for the height of a falling column of water with a small hole in the container at the bottom of the column of water through which water exits the...

    Keywords: dataSpanishtankcolumn of waterapertureTorricelli's LawConservation of EnergytSolverwater flowExcel Solver

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    5-001-LSD-ModelingScenario
    We describe the use of a two compartment model of a linear system of first order linear differential equations to model lysergic acid diethylamide (LSD) in the body. We provide the data from the...

    Keywords: LSDSpanishcompartmentpharmacokineticslysergic acid diethylamide

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    Cancer Discovery Activities
    These two hands-on activities are based on a Howard Hughes Medical Institute 2013 Holiday Lectures on Science video (http://www.hhmi.org/biointeractive/cancer-genetic-disease-video-highlights)...

    Keywords: geneticsResources @ HHMI - BioInteractiveorganismal biologyneurosciencegenomicscancergenetic basis of diseasebiology of cellsHigh School

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    How to Find a Gene: Retrieving Information From Gene Databases
    A strong understanding of distinct gene components and the ability to retrieve relevant information from gene databases are necessary to answer a diverse set of biological questions. However, often...

    Keywords: NCBItranscriptiontranslationGene StructureGene databasesEnsembl

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    Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes
    Students require a deep understanding of the central dogma before they can understand complex topics such as evolution and biochemical disorders. However, getting undergraduate biology students to...

    Keywords: Protein Structurecomputational modelingcentral dogmaplant leaf structurePhenotype/Genotype

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    Exploring Microbial Diversity: An Interactive In-Class Assignment for Biology and Microbiology Courses
    This interactive assignment engages students in a hands-on exploration of microbial diversity and the importance of microbes in ecosystems. Designed for General Biology II and Introduction to...

    Keywords: Microbiology EducationMicrobial DiversitymicrobiologyEcological Society of Americaecology educationresearch-based classroom instruction4DEE Framework

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    1-030-EyeModel-ModelingScenario
    We offer a mathematical modeling experience using differential equations to model the volume of an intraocular gas bubble used by ophthalmologists to aid the healing of a surgically repaired region...

    Keywords: retinal surgeryAkaike Information CriterionSpanishsum of square errorssurgeryretionaophthalmologyeyeintraocular gas bubble

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    6-019-EnablingEpidemicExploration-ModelingScenario
    We became aware of several interesting possibilities for a modeling opportunity with data and we invited you to explore the several routes to parameter estimation in a SIR model with respect to the...

    Keywords: Akaike Information CriterionMichaelis-Mentenepidemicsaturationgradientleast sum of square errors

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