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#1904, v1.0 Published:
#1955, v1.0 Published:

Title

Old VersionNew Version
1Understanding COVID-19 Biology to Design a Vaccine 1Understanding COVID-19 Biology to Design a Vaccine - Ethics supplement

Authors

Old VersionNew Version
1Keith Johnson () 1Keith A. Johnson ()
2Didem Vardar-Ulu (Boston University) 2Keith A. Johnson ()
3Shuchismita Dutta ()   
4Keith Johnson ()   

Description

Old VersionNew Version
1<p>The case presented here is written during the COVID-19 pandemic (Spring 2020) and uses this backdrop to introduce students to the initial stages of developing a vaccine against the SARS-CoV-2 virus, targeting its spike protein.&nbsp; The viral protein binds to a specific human protein on human epithelial cells and this initiates the infection. The structure of the viral spike and human receptor protein interaction was&nbsp; determined using cryo-electron microscopy by Yan <em>et al</em> (2020). Using the freely available molecular structural data and publicly available visualization software and bioinformatics tools and resources, the case leads students to examine the interaction of the viral spike (S) protein with the human epithelial cell ACE-2 protein, the site of viral attachment. The vaccine development discussed in this case is focused on blocking this interaction to stop infection.</p>  1<p>These supplements were designed for an upper level bioethics course, but could be used in other courses or used to develop further ethics discussions.</p>
2    
3<p>&nbsp;</p>    
4    
5<p>Painting depicting coronavirus. (Acknowledgement: Illustration by David S. Goodsell, RCSB Protein Data Bank; doi: 10.2210/rcsb_pdb/goodsell-gallery-019.)</p>   

Attachments

1 file — KeithJohnson/Johnson et al COVID-19 answer key-6180.docx 1 file — KeithJohnson/Johnson COVID-19 ethics 1 supplement.pdf
2 file — KeithJohnson/Johnson et al COVID-19 resources.docx 2 file — KeithJohnson/Johnson ethics supplement 2 wet markets.pdf
3 file — KeithJohnson/Johnson et al COVID-19 teaching notes.docx 3 file — publication_2060_2114/KeithJohnson/coronavirus.png
4 file — KeithJohnson/Johnson et al COVID-19 worksheet 1.docx
5 file — KeithJohnson/Johnson et al COVID-19 worksheet 2.docx
6 file — KeithJohnson/Johnson et al COVID-19 worksheet 3.docx
7 file — KeithJohnson/Johnson et al COVID-19 worksheet 4.docx
8 file — KeithJohnson/Johnson et al COVID-19 worksheet 5 assessment.docx
9 file — KeithJohnson/Johnson et al Worksheet 2 ethics supplement.docx
10 file — KeithJohnson/coronavirus.png