Using Yeast to Make Scientists: A Six-Week Student-Driven Research Project for the Cell Biology Laboratory

Traditionally-trained undergraduate students often lack an understanding of science as an active process that yields the information presented in their textbooks. One result has been a call for more research experiences built into traditional introductory undergraduate courses, now commonly referred to as course-based undergraduate research experiences (CUREs). The laboratory module presented in this paper used an established four-step pedagogical framework to simplify and streamline the development and implementation process of a CURE in an introductory biology laboratory setting. A unique six-week CURE was designed for undergraduates enrolled in a cell biology lab that employs Saccharomyces cerevisiae as a eukaryotic model organism. Students address a research problem that is of interest to the scientific community: Do select chemicals in the environment have adverse effects on the mitotic cell division? Students are first introduced to S. cerevisiae, its life cycle, morphology, growth curve generation and analysis, and the laboratory techniques required to cultivate this organism. Working in groups, students then act as scientists to research primary literature, ask an original question, develop a testable hypothesis, collaborate with peers, design and conduct an experiment, analyze and interpret data, and present their work to their peers. In addition, students are involved in multiple levels of iterative work, including addressing problems or inconsistencies, ruling out alternative explanations, and/or gathering additional data to support assertions.

0 comments 6 reposts

Profile picture of Jeanne Sinara

Jeanne Sinara onto Cell Biology

Molecular CaseNet - Developing and Using Molecular Case Studies at the Interface of Biology and Chemistry (RCN-UBE Introduction)

A community of educators and scholars developing and using Molecular Case Studies (MCS), to explore the molecular basis of biological phenomena, understand real world problems, and their developing solutions at the interface of biology and chemistry.

0 comments 1 reposts

Profile picture of Jeanne Sinara

Jeanne Sinara onto Biological Molecules

Joel E. Greengiant Learns About Peas: From Nucleotides to Selection

This case study follows purveyors of peas, Joel E. and Jolene Greengiant, as they learn about the origin, biochemistry, genetics and eventual artificial selection of sweet (wrinkled) peas, all in the context of evolutionary biology.

0 comments 1 reposts

Profile picture of Jeanne Sinara

Jeanne Sinara onto Biological Molecules

BioMolViz - Development of an Inclusive Community for the Instruction of Visualizing Biomolecules (RCN-Introduction)

BioMolViz is a community dedicated to advancing biomolecular visualization education. We provide training, teaching tools and validated visual literacy assessments. The BioMolViz Library—our online repository—delivers assessments to instructors worldwide.

0 comments 1 reposts

Profile picture of Jeanne Sinara

Jeanne Sinara onto Biological Molecules

Cystic Fibrosis Mechanism and Treatment

This animation shows how mutations in an ion channel protein lead to the genetic disease cystic fibrosis. The animation also discusses how research on this protein has been used to develop treatments for the disease.

0 comments 1 reposts

Profile picture of Jeanne Sinara

Jeanne Sinara onto Biological Molecules

A "Box of Lessons" for Exploring Biomolecular Structure and Function

Biomolecular structure and function is emphasized as a core concept in a variety of community determined educational standards for biology and chemistry. Most curricula introduce students to the building blocks and principles of biomolecular structures, in introductory chapters of biology, biochemistry, cell biology, and chemistry courses, but very few engage students in actively visualizing and exploring biomolecular structures throughout the course. Conversations with faculty teaching introductory courses, and/or developing and piloting molecular case studies, helped uncover the need for new resources, and professional development to support introduction of biomolecular exploration. To address this need, a group of faculty participating in a Faculty Mentoring Network in Spring 2022, gathered together resources and lessons that they had independently developed and collaboratively developed additional ones. An overview of the lessons will be presented here. Interested users are invited to pilot the lessons in Fall 2022.

0 comments 5 reposts

Profile picture of Jeanne Sinara

Jeanne Sinara onto Biological Molecules

Electron Location, Location, Location: Understanding Biological Interactions

Collection of resources that help teach biochemistry.

0 comments 6 reposts

Profile picture of Jeanne Sinara

Jeanne Sinara onto Biological Molecules