Maria vs Malaria - AR Adaptation

04 Nov 2023 | Contributor(s): Didem Vardar-Ulu, Saif Eldeen Ragab, Swati Agrawal | doi:10.25334/Y0D3-QX42

This case study focuses on a specific enzyme Lactate Dehydrogenase (LDH) in the malarial parasite as a target for treating malaria. Students will be able to view selected molecular views from the story in 3D using Augmented Reality.

Box of Lessons: A Toolkit for Introducing Students to Biomolecular Structure and Function

30 Oct 2023 | Contributor(s): Sheela Vemu, Alexandra Pettit, Shuchismita Dutta | doi:10.25334/CM1V-FW77

This is a poster describing a collection of open educational resources that were developed by faculty participating in the Molecular CaseNet Faculty Mentoring Network in Spring 2022. The collection was then reviewed and piloted and is now ready for publishing.

The Molecular CaseNet Pipeline for Authoring, Piloting, and Evaluating Molecular Case Studies

31 Oct 2023 | Contributor(s): Alexandra Pettit, Elizabeth Pollock, Kristen Procko, Kasandra Riley, Didem Vardar-Ulu, Shuchismita Dutta | doi:10.25334/9G7Y-8E04

This poster provides an overview of the pipeline for authoring, piloting, and reviewing molecular case studies for publication in Molecular CaseNet.

Molecular CaseNet - Developing and Using Molecular Case Studies at the Interface of Biology and Chemistry (RCN-UBE Introduction)

31 May 2023 | Contributor(s): Shuchismita Dutta, Caleb Trujillo | doi:10.25334/VKQN-0X96

A community of educators and scholars developing and using Molecular Case Studies (MCS), to explore the molecular basis of biological phenomena, understand real world problems, and their developing solutions at the interface of biology and chemistry.

Box-of-Lessons Review, Fall 2022 - YouTube

07 Dec 2022 | Contributor(s): Alexandra Pettit, Sheela Vemu, Shuchismita Dutta | doi:10.25334/SRG3-FM52

This video described the working group activities for BIOME Institute 2022 - Fall working group

A "Box of Lessons" for Exploring Biomolecular Structure and Function

20 Jul 2022 | Contributor(s): Keith A. Johnson, Alexandra Pettit, Sheela Vemu, Shuchismita Dutta | doi:10.25334/K480-QR38

Biomolecular structure and function is emphasized as a core concept in a variety of community determined educational standards for biology and chemistry. Most curricula introduce students to the building blocks and principles of biomolecular structures, in introductory chapters of biology,...

Collaborative case writing and field testing with Molecular CaseNet brings together discipline specific expertise for innovative pedagogical tools in the classroom

15 Jul 2022 | Contributor(s): Swati Agrawal, Didem Vardar-Ulu, Serena Yu, Shuchismita Dutta | doi:10.25334/HZGX-MF51

Molecular case studies (MCS) use an interesting story as a hook , followed by exploration of biochemistry of one or more molecules of interest.  They can be useful in teaching about macromolecule structure and function and also for improving biomolecular visualization and analysis in...

Ecology/Environmental Biology Molecular Case Studies for Molecular CaseNet - YouTube

06 Dec 2021 | Contributor(s): Debra Linton, Heather Simpson, Jennifer Glee Buntz, Sheela Vemu, Shuchismita Dutta | doi:10.25334/Z1G8-TD15

Biome Institute 2021, Fall Working Group Summary Video

Learning about Protein Structure and Function with Molecular CaseNet

22 Jul 2021 | Contributor(s): Laurel Lorenz, Keith A. Johnson, Anya Goodman, Shuchismita Dutta | doi:10.25334/HWN6-4F11

Poster on the case studies available through Molecular CaseNet that focus on protein structure and function. Presented at the 2021 BIOME Institute.

Students Authoring Molecular Case Studies

22 Jul 2021 | Contributor(s): Elizabeth Pollock, Kasandra Riley (She/Her), Didem Vardar-Ulu, Shuchismita Dutta | doi:10.25334/M0P7-DQ22

Poster on using case studies to help students develop their skills in reading primary literature and identifying authentic scientific problems by authoring their own case studies. Presented at the 2021 BIOME Institute.

Molecular CaseNet - Students Writing Cases - YouTube

03 Dec 2020 | Contributor(s): Didem Vardar-Ulu, Elizabeth Pollock, Kasandra Riley (She/Her), Nik Tsotakos, Swati Agrawal, Shuchismita Dutta | doi:10.25334/DXWJ-R020

Biome Institute 2020, Summary Video

Molecular CaseNet - Developing Intro Tutorials - YouTube

03 Dec 2020 | Contributor(s): Jean Cardinale, Keith A. Johnson, Marie C. Montes-Matias, Natalie Stringer, Aeisha Thomas, Shuchismita Dutta | doi:10.25334/7GER-QS63

Biome Institute 2020, Summary Video

Sickle Cell Anemia using Nicholas’ Story

25 Jun 2020 | Contributor(s): Sharon Cisneros | doi:10.25334/Z773-JS90

The goal of this exercise is to introduce students to 3-D structures of biological molecules, visualize and manipulate them to understand their functions. The exercise also helps them see the effect of changing an amino acid.

The Happy Blue Baby Hemoglobin

14 Jun 2020 | Contributor(s): Kasandra Jean-Louise Riley, Shuchismita Dutta | doi:10.25334/N5JP-1P96

This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved.

COVID-19: Molecular Basis of Infection

12 Jun 2020 | Contributor(s): Didem Vardar-Ulu, Shuchismita Dutta | doi:10.25334/HQCA-QD59

This case was written in Spring 2020 during the COVID-19 pandemic. It focuses on understanding the structure and interaction of the SARS-Cov-2 viral spike protein that facilitates infection in human cells.

A Case of Severe Insulin Resistance

12 Jun 2020 | Contributor(s): Melanie Lenahan, Shuchismita Dutta | doi:10.25334/DTTA-WW18

This case focuses on understanding how a mutation in a cell signalling protein (a kinase) can prevent insulin function and lead to diabetes.

Piwi Matters

12 Jun 2020 | Contributor(s): Laurel Lorenz, Shuchismita Dutta | doi:10.25334/ZM3H-4149

This case focuses on understanding structure and function relationships in Piwi, a protein that is critical for germline stem cell function and development of eggs in the fruit fly ovary.

Evolution of Caffeine Biosynthesis Enzymes

12 Jun 2020 | Contributor(s): Brian Sullivan, Shuchismita Dutta | doi:10.25334/225Z-KR22

This case focuses on exploring why plants make secondary metabolites like caffeine and how the enzymes required for making caffeine evolved.

Waking up Anna

11 Jun 2020 | Contributor(s): Kate K. O'Toole, Shuchismita Dutta | doi:10.25334/Y88F-9279

This case focuses on understanding the molecular basis of Anna's sleeping disorder and its treatment.

Nicholas' Story

11 Jun 2020 | Contributor(s): Shuchismita Dutta, Kimberly Linenberger Cortes, Henry Vincent Jakubowski, Melanie Lenahan, David Marcey, Pat Marsteller, Cassidy Terrell | doi:10.25334/H82J-3C28

This 3 part case on sickle cell disease focuses on visualizing and understanding the molecular basis of its cause, symptoms, complications, management, treatment, and possible cures.

Understanding COVID-19 Biology to Design a Vaccine

12 Jun 2020 | Contributor(s): Keith Johnson, Didem Vardar-Ulu, Shuchismita Dutta | doi:10.25334/DNC7-8581

This multi-part case study introduces the reader to the SARS-CoV-2 virus, replication, and treatment. Additional worksheets introduce students to bioinformatics tools of 3-D protein visualization and BLAST searches.

Happy Blue Baby

11 Jun 2020 | Contributor(s): Shuchismita Dutta | doi:10.25334/2R67-W933

This case, about a specific mutant of hemoglobin, focuses on visualizing and understanding the molecular basis of why an infant turned blue soon after birth and how the cyanosis resolved on its own in a few months.